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Supplement that has had largest effect on skin


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#121 TheFountain

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Posted 30 July 2013 - 03:58 AM

For those who say that c60 olive oil works wonders for the skin, I am wondering if you mean from internal application or external? Also, how long would the 30 ml bottle last and how exactly is the applicator used? Thanks.

#122 sthira

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Posted 30 July 2013 - 06:59 PM

For those who say that c60 olive oil works wonders for the skin, I am wondering if you mean from internal application or external? Also, how long would the 30 ml bottle last and how exactly is the applicator used? Thanks.


They're eating it. You can make it yourself and play. Maybe it's safe. Buy it from SES, crush it with a pestle, measure it, dump the black mess into a bottle of oil, shake the oil bottle for a few weeks, a month. The oil turns reddish in color, and particles get smaller till they appear to disappear. Point ur cat toy fun laser into the bottle to see what's floating. But I think the buckyball structure itself is too large for miraculous pore dive expeditions.
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#123 niner

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Posted 30 July 2013 - 08:08 PM

But I think the buckyball structure itself is too large for miraculous pore dive expeditions.


It's not really very big- only one nanometer in diameter, by itself. I'd be more concerned about the triglycerides that it's bound to. They increase size and MW considerably, but more importantly, the active species is almost certainly the fatty acid adduct rather than a triglyceride adduct, so the triglyceride needs to be digested (hydrolyzed) in order to form the active agent. That may or may not occur in skin, but is a normal part of our digestion of lipids.

#124 TheFountain

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Posted 30 July 2013 - 09:40 PM

How long does the 30 ml bottle last when taken once a day at the recommended dose?

#125 YOLF

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Posted 31 July 2013 - 12:45 AM

My suggestion is obviously cryonics. If doctors today can't fix you and it puts your life in such shambles, live for tomorrow (though it may be fairly far away in terms of time). People who are well informed on cryonics feel that there is currently a 50-80% of being reanimated.... Neuro stasis/suspension starts at $10K plus transportation to Russia, the oldest Cryo company in the US charges $28-35K for domestic full body services depending on whether or not you pay ahead of time. Then there is always Alcor who's services last I checked run between $80K for neuro and $200K for whole body. Standby services run $88K through Suspended Animation IIRC. Rudi can give you all of the most up to date info.


Thanks, but that is really not an option. It is overkill to the nth degree to submit to cryogenic freezing with the hope that I may be revived, and if so, that there is will treatment and/or an understanding of this issue. And all of this for a skin issue and a life that I don't really care much for to begin with. It is like using a sledge-hammer for a thumb tack. I don't subscribe to the mostly erroneous notion of cultural/technological progress, anyways. I have no faith in the future whatsoever. I see it devolving in an increasingly dystopian fashion until our species finally eradicates itself, which won't be long...thankfully.


Often people who think so negatively as you seem to, don't understand the future or what we have at present. It would be a pitty to die early or to forgo a life that may someday prove you wrong. I'm not saying you get cryonics immediately, but that you've spent this life suffering from a disease you won't have in the next and that it'll change things for you. Probably for the better. If we indeed eradicate ourselves it will be through methods such as eugenics. You also don't know that you won't get thawed before the bomb drops (if that's what you expect) and have an opportunity to campaign against dropping it.

I had someone tell me once that they wouldn't want to live in the future and it was because he didn't think that a future who thawed cryonicists would be a successful or respectable one. He didn't think I was worth my existence either. He thought the same way you do. I wouldn't be surprised if you got that notion from someone who hated you.

Please do reconsider. Engineering can already rebuild us if given the time and massive sums of money required, now it's just a matter of ending aging. I'm working on methods of human molecular remanufacturing and I consider the solution to be in the box. For anyone who hasn't suffered a videogame style headshot with a shotgun, and who gets a quality preservation, the chances of being repaired are nearly 100% in favor of success. All the the tech needed to do what I'm talking about is published and it's just a matter of time until someone makes these techs commonplace and we're able to build and demonstrate the technology on the budget we have at that time.

Don't throw your life away!

#126 Soma

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Posted 02 August 2013 - 10:52 PM

I will try the C60 olive oil and this is probably the last experiment I have the will and energy for. If this doesn't work, I will officially give up. I probably may as well end it at that point, because my life is abject torment and it is really just utterly masochistic to continue on. I have nothing to live for, as this condition has taken everything in life away from me. I have come to see that persevering in the face of an insurmountable problem is really just another disease of the mind. We tend to praise people for this, as though it is valiant and heroic, but it is none of this...it is irrational, confused, and just torturously delays the inevitable. The hope that I would eventually find something to heal, reverse, or at least ameliorate this terrible problem has been the only thing, and I truly mean the only thing that has kept me going...but that hope is all but dead, hanging on by a cobweb. I am not afraid to die. Suffering is what I wish to avoid, not death.

I used to have a lot of faith in nutrition, alternative/complimentary medicine...but I really do think that we are prisoners of genes, period. Nutrition likely does little to nothing to alter the course of one's life and nutritional supplements are quite possibly the biggest racket going. There may be a reason why nobody ever feels like supplements are actually doing anything. That's because they aren't. The nutritional supplement industry is largely a giant fucking scam. I am not much of a proponent for making anything in particular illegal, but I wouldn't mind one bit if the government or the WTA made supplements illegal, like the wild-eyed conspiracy theorists are always banging on about. It would save a lot of witless nitwits from wasting their money on fucking sugar pills. Why in the 21st century, we still tolerate the peddling snake oil to credulous morons is beyond me. One more testament to the inherently unscrupulous nature of the irrevocably fucked animal that is the human being.

Edited by Soma, 02 August 2013 - 11:13 PM.


#127 Ark

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Posted 03 August 2013 - 02:54 PM

Aspirin gives me adverse negative reactions of the skin nature, sometimes.

Edited by Ark, 03 August 2013 - 02:54 PM.


#128 nowayout

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Posted 04 August 2013 - 07:10 AM

I will try the C60 olive oil and this is probably the last experiment I have the will and energy for. If this doesn't work, I will officially give up. I probably may as well end it at that point, because my life is abject torment and it is really just utterly masochistic to continue on. I have nothing to live for, as this condition has taken everything in life away from me.


What skin condition do you have, if i may ask, that is worth considering suicide over?

#129 niner

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Posted 04 August 2013 - 01:34 PM

I will try the C60 olive oil and this is probably the last experiment I have the will and energy for. If this doesn't work, I will officially give up. I probably may as well end it at that point, because my life is abject torment and it is really just utterly masochistic to continue on. I have nothing to live for, as this condition has taken everything in life away from me.


What skin condition do you have, if i may ask, that is worth considering suicide over?


Something similar to, but not identical to ichthyosis, based on earlier discussions.

#130 niner

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Posted 04 August 2013 - 01:53 PM

I will try the C60 olive oil and this is probably the last experiment I have the will and energy for. If this doesn't work, I will officially give up. I probably may as well end it at that point, because my life is abject torment and it is really just utterly masochistic to continue on. I have nothing to live for, as this condition has taken everything in life away from me. I have come to see that persevering in the face of an insurmountable problem is really just another disease of the mind. We tend to praise people for this, as though it is valiant and heroic, but it is none of this...it is irrational, confused, and just torturously delays the inevitable. The hope that I would eventually find something to heal, reverse, or at least ameliorate this terrible problem has been the only thing, and I truly mean the only thing that has kept me going...but that hope is all but dead, hanging on by a cobweb. I am not afraid to die. Suffering is what I wish to avoid, not death.


Soma, you have a good reason to be depressed and angry. You have the psychological pain of thinking that you look like a monster, although I suspect that not everyone in your life is quite so put off by your appearance. You probably have physical pain associated with your condition. Modern medicine may not be able to cure you, but they are very good at dealing with physical pain. That part of your condition could be addressed medically, by a pain specialist if necessary. For the psychic pain, I'd take a look at cognitive behavioral therapy. CBT could train your mind to think differently about your situation, and in so doing, deal with much of the psychic pain. As far as having a reason to live, you're obviously intelligent and a good writer. Those skills could do good and could make you money.

I hope that you find a way out of your pain.
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#131 Soma

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Posted 04 August 2013 - 03:10 PM

Yes, it is ichthyosis-like coupled with persistent, intractable infection, with a special affinity for my facial skin. It causes appreciable physical pain (painful sores, itching, burning, sensitivity) and unimaginable psychological pain. It is misery and I do think that it is a misery worth ending, in any way. The only thing that ever changes with my skin is the continuous disfiguring scarring to my face. Over the years, my confidence has been incrementally dismantled, and today, it is gone. Niner, thank you for your concern and your advice. You seem like a genuinely caring person. I'll look into to CBT, but to be honest, I'm not sure that I have the energy, the will, or even the desire for it. I am not really interested in desperately scrambling to find a way to make my life endurable- to find a way to cope so that I may trudge on. Life doesn't hold that much of a sway over me that I will seek to perpetuate it at all costs.

As I have said before, I came to this site for its wealth of health information. Philosophically, I am distinct from most here. I am not a futurist, a trans-humanist, or proponent of an indefinite lifespan. I don't possess an unexamined, quasi-neurotic survival anxiety, which in my opinion, is quite obviously primary impetus of organization such as this, and implicitly in the near universal and insatiable human drives for money, power, status, and fame. I lack these drives. Even my basic animalistic survival instinct has been slowly but inexorably chipped away as well. In the end- like Ernest Becker- I am not a denier of death. I have transitioned from accepting it to welcoming it, as it may be the only way out of my pain.
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#132 HHM

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Posted 04 August 2013 - 03:32 PM

LLLT (low level laser therapi). I have build my own device using 650 laser diodes each providing 5 mW red laser light of 650 nm wavelenght. I build it to restore hair growth but it also have had a significant effect on my scalp skin. You can Either build one yourself (see www.overmachogrande.com for a DIY guide) or buy one via the same site. Sincerely hope this will help you

#133 YOLF

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Posted 05 August 2013 - 06:28 AM

Soma, in some of your earlier writings you kinda flamed the human species. It sounds like you hold a pretty high standard for people. You should really, read "The Prospect of Immortality" (the book is free, give it a google) it was written by the founder of cryonics a few decades ago and the progress achieved since its authoring is somewhat impressive, yet Ettinger (the author) sets some pretty high moral expectations. Cryonics is entirely plausible given time, and most have family that follow them. So you won't be as alone as you might think and your choice might inspire future generations in your family to become cryonicists. The most important people in the long term are your family anyways. Looking to my family for an example, my mother has one long term friend that she has known for a few decades and now, as she nears 65 her friends seem to come and go, she's become accoustomed to death and the loss of loved ones. But aside from that one friend, she still keeps in touch regularly with her sisters and a cousine or two, and besides my siblings, that's about it. My dad on the other hand probably hasn't had friends for as long as I can remember, he only talks to my siblings.

If I didn't mention it before, the Society for Venturism raises money for those who can't afford cryonics. You should read about Aaron Winborn and Kim Suozzi. They are both brave souls who we'll see in the future. You really aren't alone and anything is possible.

#134 nowayout

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Posted 05 August 2013 - 06:45 AM

Soma, I'm sorry to hear. I fully agree with you that supplements are pretty much snake oil - pretty much all of them we have right now - so this particular forum is a recipe for disappointment. But there may be some pharmaceutical drugs that may be of help (e.g., antibiotics for your constant infections). And have you talked to a dermatologist specialising in plastic surgery? They can do wonders these days with things like dermabrasion, various kinds of laser therapies, fillers, and actual surgery, even skin cloning and transplant. I am sure there must be some solutions that can help you. Since this is a real condition (and not vanity procedures) you may well be covered by insurance (if you have it).

Edited by nowayout, 05 August 2013 - 06:46 AM.


#135 YOLF

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Posted 06 August 2013 - 05:43 AM

Hmmm... I remember hearing about a case study where the patient's skin pretty much melted off as a reaction to a particular drug and they were able to regrow her skin from head to toe with stem cell infused sheets made from donor blood. I never was able to find the study, and it's probably been about 10 years since I initially heard about it. You might think about having some of your skin removed and regrown from your own modified cells in this way. If it works well (the case study chick had baby-like skin), you might think about regrowing your entire epidermis while in a drug induced coma.

Sounds gross, but if you're brave and the case study follow data looks good...

You would probably be able to use your own blood cells and have the gene that causes it knocked out if they know which one it is.

Edited by cryonicsculture, 06 August 2013 - 05:45 AM.


#136 Soma

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Posted 14 August 2013 - 03:36 PM

I just wanted to extend a sincere thank you everyone who tried to help me. I don't have anything left. I have no more will.
Te torment is too much to endure. Biological life is a horrible horrible accident. It would have been infinitely better had it never happened.
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#137 blood

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Posted 24 August 2013 - 07:37 AM

I hope you are still with us, Soma.

I have never been a candidate for accutane as my skin is excessively dry to begin with.


Perhaps you are dismissing systemic retinoids too quickly?

Isotretinoin has apparently been used with success with people with ichthyyosis (as well as psoriasis, rosacea & acne).

If a dermatologist won't prescribe it, you could "self-prescribe" & purchase from an online pharmacy.

http://www.ncbi.nlm..../pubmed/7040514

J Am Acad Dermatol. 1982 Apr;6(4 Pt 2 Suppl):716-20.

Treatment of ichthyosis with isotretinoin.

Baden HP, Buxman MM, Weinstein GD, Yoder FW.

Abstract

A multicenter study of the effectiveness of 13-cis-retinoic acid (isotretinoin) in lamellar ichthyosis and epidermolytic hyperkeratosis has been conducted. A dose of the drug which produced maximum clearing with minimum side effects was chosen; this varied among different patients, the mean dose being about 2 mg/kg/day. Almost all of the patients in both groups were clearly improved, as evaluated both by the physicians and the patients. The degree of improvement seemed higher in the group of patients with lamellar ichthyosis.

PMID: 7040514 [PubMed - indexed for MEDLINE]


Tazarotene - used topically in gel form - seems to be useful in several kinds of ichthyosis:

http://www.ncbi.nlm....pubmed/12823301

Clin Exp Dermatol. 2003 Jul;28(4):391-3.

Type I lamellar ichthyosis improved by tazarotene 0.1% gel.

Abstract

The efficacy of tazarotene 0.1% gel in a 30-year-old woman with type I lamellar ichthyosis is reported. The drug was applied to 15% of the total body surface area as follows: once daily for 2 weeks, three times a week for further 2 weeks, followed by a once weekly maintenance application. During the first week of treatment there was partial improvement obtained and in the next 14 days further reduction of scaling within the tazarotene-treated areas was observed. After 4 months of maintenance application, there was a marked overall improvement in the treated areas. Side-effects consisted only of mild pruritus, slight burning and irritation. In essence, the therapeutic benefit obtained was comparable with that of systemic retinoids but without the adverse systemic side-effects. As noted in other reports, tazarotene 0.1% gel seems to be a valuable and safe therapeutic option for this severe genodermatosis.
PMID: 12823301 [PubMed - indexed for MEDLINE]



Tazarotene gel can be ordered from alldaychemist for less than $10/ tube (if your dermatologist won't prescribe it).


Another systemic retinoid - Actitretin - appears to be a standard treatment for various types of ichthyosis. Did your dermatologist try it with you?

http://www.ncbi.nlm....pubmed/17263800

Br J Dermatol. 2007 May;156(5):965-73. Epub 2007 Jan 30.

Oral liarozole vs. acitretin in the treatment of ichthyosis: a phase II/III multicentre, double-blind, randomized, active-controlled study.

Abstract

BACKGROUND:
Liarozole, a retinoic acid metabolism blocking agent, has been granted orphan drug status for congenital ichthyosis by the European Commission and the U.S. Food and Drug Administration.

OBJECTIVES:
The purpose of this trial was to investigate the efficacy, tolerability and safety of oral liarozole vs. acitretin in patients with ichthyosis.

METHODS:
In this double-blind comparative trial of liarozole vs. acitretin, 32 patients with ichthyosis were randomized to be treated with either oral liarozole 75 mg in the morning and 75 mg in the evening or with acitretin 10 mg in the morning and 25 mg in the evening for 12 weeks. Clinical efficacy, tolerability and safety were monitored.

RESULTS:
Between-group comparisons for efficacy and tolerability revealed no statistically significant differences except for scaling on the trunk at baseline which was significantly worse in the liarozole group (P = 0.024) and showed a more pronounced improvement in this group than in the acitretin-treated patients (P = 0.047). Based on the overall evaluation of the response to treatment at endpoint, 10 of 15 patients in the liarozole group and 13 of 16 patients in the acitretin group were considered by the investigator to be at least markedly improved. The expected retinoic acid-related adverse events were mostly mild to moderate and tended to occur less frequently in the liarozole group. No serious adverse events related to the drugs occurred.

CONCLUSIONS:
The present study indicates that liarozole at a daily dose of 150 mg is equally effective as a treatment for ichthyosis as acitretin but shows a trend towards a more favourable tolerability profile. The results of this trial warrant further clinical trials to confirm efficacy and safety of liarozole as an orphan drug in ichthyosis.


Apologies if you have already explored some of these options.

#138 nowayout

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Posted 24 August 2013 - 08:38 AM

Just be careful as systemic retinoids can have serious side effects including depression, which you don't want to have more of.

It sounds like teatment for depression should at this point be a priority. Please consider it.

Edited by nowayout, 24 August 2013 - 08:41 AM.


#139 mrd1

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Posted 09 September 2013 - 10:28 PM

Sunscreen 1-three times a day despite not being outside all day or never getting burned that doesn't matter. There are TWO types of UV waves one A and the other B. The B burns your skin however has trouble penetrating deep. However, the UV A, while not burning you, causes your skin to age and can penetrate deep and because of that it can seep through glass and cause aging EVEN IF STILL INSIDE! Evidence of this is when they measure the wrinkles on British truck drivers and the wrinkles are localized to the side of their face exposed to the sun but never "outside or burned". This does not mean you will never find someone who goes outside and doesn't use sunblock who doesn't also have amazing skin. Many variables contribute to the complexion of ones skin and n to the 1 means nothing. This is BECAUSE if you look at a graphical depiction of the law of large numbers at first you see MASSIVE variation however, over many many many trials you start to see a clear picture emerge. If you find someone who has flipped two pennies and gotten tails twice in their PERSONAL experience that does not mean UNIVERSALLY the AVERAGE is not still 0.5. Based on a research method where you pool to gather and analyse many many studies called META-ANALYSIS it is clear that a trend has emerged after CONTROLLING FOR EXTRANEOUS AND CONFOUNDING VARIABLES that sunscreen CAN help prevent skin aging, fine lines, and wrinkles. And, one can theorize that this could make sense after you better understand the phenomena of UV rays and skin aging. This is not to say there wont be someone out in the sun all day with amazing skin, what it is saying is for you the EXPECTED VALUED [(Xi*%+....Xn*%)/n] will be NEGATIVE if you goal (or OPERATIONAL DEFINITION of what would make this a success) is aesthetically pleasing and slow aging skin. Some people win the lottery, even more break even, but the expected value of the lottery is still extremely NEGATIVE! Now, the research may be wrong and the rogue pseudoscience, nutritionists, and self help gurus correct. However, I know that over my DOZENS if not HUNDREDS of behaviors if I rely on DATA and theories that are FALSIFIABLE and generating expected values that is reasonably assumed to probably exist ill probably be better off than if I have ten guys all telling me their own spin on life and different often contradictory and ineffective radical ideas. They certainly have a few gems but I don't got time to go through all that hay to find it nor have the tools to even be able to tell if its hay or a diamond because it isn't carefully controlled double blind studies and EXPERIMENTS are the ONLY way to prove CAUSATION. I am 100% certain one lottery ticket will make me a millionaire but I think Ill put my money, time, and effort in something with a much less grandiose but probable expected return.

Edited by mrd1, 09 September 2013 - 10:39 PM.

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#140 Strangelove

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Posted 11 September 2013 - 03:34 PM

Hmmm... I remember hearing about a case study where the patient's skin pretty much melted off as a reaction to a particular drug and they were able to regrow her skin from head to toe with stem cell infused sheets made from donor blood. I never was able to find the study, and it's probably been about 10 years since I initially heard about it. You might think about having some of your skin removed and regrown from your own modified cells in this way. If it works well (the case study chick had baby-like skin), you might think about regrowing your entire epidermis while in a drug induced coma.

Sounds gross, but if you're brave and the case study follow data looks good...

You would probably be able to use your own blood cells and have the gene that causes it knocked out if they know which one it is.


Soma, are you still here? I am afraid I do not have much to say but maybe you want to check this out. I remembered an anecdote from a person from very deep scars from acne. He had a very deep acid peel and regenarated his skin with the method described above. I am not sure about your financial situation but in any case have hope, this is something doable today. I am very sorry that people were not able to help you find a cure in your thread.



LLLT (low level laser therapi). I have build my own device using 650 laser diodes each providing 5 mW red laser light of 650 nm wavelenght. I build it to restore hair growth but it also have had a significant effect on my scalp skin. You can Either build one yourself (see www.overmachogrande.com for a DIY guide) or buy one via the same site. Sincerely hope this will help you


Hi HHM, could you describe this in more detail? What effects do you have from the laser on hair restoration and skin health?

#141 blood

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Posted 20 September 2013 - 11:21 AM

Soma, are you still here?


Soma's last post read to me like a suicide note.

:sad:
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#142 cuprous

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Posted 22 September 2013 - 12:05 AM

I just wanted to extend a sincere thank you everyone who tried to help me. I don't have anything left. I have no more will.
Te torment is too much to endure. Biological life is a horrible horrible accident. It would have been infinitely better had it never happened.


Soma I don't know if you will ever read this but I wanted to offer you a small thought all the same.

While nobody can fully appreciate what it is like to live with your condition there are people who make the choice to end their lives for far more trivial matters -- they think they are overweight, they perceive themselves as "failures" for any number of inane reasons, on and on. How many beautiful women go vomit after a meal because they think they are unattractive? You might dismiss them as not knowing what "true" suffering is like but outside of your physical discomfort your psychic pain is every bit as construed as theirs. And surely there are others in this world who would wish only to have your condition.

So much unhappiness and pain comes from the disconnect from what is with what we want or don't want. The more we resist and hinge out happiness on externalities the more we despair that we will never get "there." And even when we do manage to achieve this or that it is more often than not a temporary gratification.

Let go of it all -- the hopes of things changing, the idea of being cursed, the artifice of your self-opinion. Throw it all away! This isn't an attempt to push any religion on you but see if there is a mindfulness center near you. Learn to slowly find ways to shed this crushing mountain of self revulsion and psychic agony. It is possible. It is doable.

Though we will never meet I am one person who will hope that today is the day you begin to perceive and unlock all of the chains, traps, and other instruments you have been affixing to yourself.

Be well.
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#143 lemonhead

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Posted 22 September 2013 - 12:58 AM

Strangelove,

I used a laser hair comb after I had a baby and my hair got very thin. My stylist (a guy) recommended it. It caused my hair to grow/thicken but I did not like it since the new hair came out coarse and wiry. I would recommend it to men who keep their hair short, however. My hair grew in much thicker after I started taking B vitamins; Biosil helps, too. I didn't notice any skin changes from using the laser comb.
I still have the comb around here somewhere...

#144 Soma

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Posted 03 April 2014 - 09:58 PM

Soma's last post read to me like a suicide note.
:sad:


No, I'm still here. I took a long break from everything. I am still struggling immensely...but thank you for caring. I'm strongly considering C60oo, but I certainly don't expect much. If it can help at all, I would be appreciative.
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#145 Turnbuckle

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Posted 04 April 2014 - 12:44 AM

As for C60 in EVOO applied directly to the skin, I've found it only slightly better than EVOO by itself, while a gram of ascorbyl palmitate in a few ounces of EVOO is a whole lot more effective.

#146 Soma

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Posted 04 April 2014 - 05:01 PM

I still struggle with the notion of ingesting C60. The safety studies seem inconsistent and there doesn't seem to be any evidence in terms of long-term effects. Basically, I really don't want to end up with dna mutations on top of a terrible skin condition. On the other hand, if there was any condition that would impel me to experiment with a potentially risky substance, this skin disease would be it.

I suppose a three month course would be long enough to fairly judge the potential of this substance vis-à-vis my particular condition and any improvements I may receive. Does this seem like a fair trial period?



#147 Orthorexic

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Posted 25 April 2014 - 11:19 PM

Have you ever tried immunomodulators, like elidel (aka pimecrolimus) and protopic (aka tacrolimus)? Maybe even a low-dose systemic immunomodulator - under supervision obviously - to see how your skin reacts?

 

https://en.wikipedia...ki/Pimecrolimus

https://en.wikipedia...wiki/Tacrolimus

 

What about light therapy? Or alternatively a good dose of natural sunlight daily?

 

https://en.wikipedia...i/Light_therapy

 

Do you know if you have an allergy? Have you ever had a thorough skin allergy test?

 

https://en.wikipedia...in_allergy_test

 

Have you ever been tested for (late-onset) biotinidase deficiency?

 

https://en.wikipedia...dase_deficiency

 

Like suggested earlier, I would also consider isotretinoin or even topical tretinoin. Dryness could be alleviated with a good moisturizer.

 

https://en.wikipedia...ki/Isotretinoin

https://en.wikipedia.../wiki/Tretinoin

 

Things like calcipotriol, lithium gluconate, zinc PCA, azelaic acid, benzoic acid, salicylic acid, resorcinol, urea, epsom salt, oregano oil, ciclopirox and metronidazole, might be worth a try as well.

 

https://en.wikipedia...ki/Calcipotriol

https://en.wikipedia...ki/Azelaic_acid

https://en.wikipedia...ki/Benzoic_acid

https://en.wikipedia.../Salicylic_acid

https://en.wikipedia...wiki/Resorcinol

https://en.wikipedia.org/wiki/Urea

https://en.wikipedia...gnesium_sulfate

https://en.wikipedia...wiki/Ciclopirox

https://en.wikipedia...i/Metronidazole

 

As for the scars, there are many options to tackle those. With dermabrasion, CO2 laser resurfacing, chemical peels, collagen injections, silicone gel/sheets, small skin grafts and cosmetic camouflage, tremendous improvement is possible.

 

https://en.wikipedia...ki/Dermabrasion

https://en.wikipedia...n_dioxide_laser

https://en.wikipedia...i/Chemical_peel

https://en.wikipedia...en#Medical_uses

https://en.wikipedia...cone_scar_sheet

https://en.wikipedia...i/Skin_grafting

https://en.wikipedia...etic_camouflage

 

I would also seriously seek treatment for your depression. Not only will you feel better, it could help your skin too. Psychological distress is a known eczema trigger.



#148 SanjayK

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Posted 27 April 2014 - 12:43 PM


How about looking at digestive issues? I've noticed that addressing SIBO & Candida helped my skin.

Here-s an example - after ingesting a lot of coconut oil every day (was taking 4-5tbsp per day and now just 1-2 in my morning coffee) I had the bags and darkness under my eyes improve.

Taking collagen has given my face somewhat of a 'glow'.

But none of this is miraculous. I have very dry/scaly skin on my legs and my feet are dried and heels are very rough - in spite of my skin being less dry overall and my face improving my legs/feet are pretty much the same.

Even applying coconut oil topically daily doesn't fix it.

#149 Orthorexic

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Posted 27 April 2014 - 02:11 PM

How about looking at digestive issues? I've noticed that addressing SIBO & Candida helped my skin.

 

Good point. I realize that Soma doesn't have rosacea, but the following report does show that intestinal issues could be detrimental to our skin:

 

 

http://www.ncbi.nlm....pubmed/18456568

 

Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication.

 

Abstract

BACKGROUND & AIMS:

To better understand the role of small intestinal bacterial overgrowth (SIBO) in rosacea, we aimed to assess the presence of SIBO in patients with rosacea and the clinical effectiveness of its eradication.

METHODS:

We enrolled 113 consecutive rosacea ambulatory patients (31 M/82 F; mean age, 52 +/- 15 years) and 60 healthy controls who were sex- and age-matched. Patients and controls underwent lactulose and glucose breath tests (BTs) to assess the presence of SIBO. Patients positive for SIBO were randomized to receive rifaximin therapy (1200 mg/day for 10 days) or placebo. A group of patients with negative BTs were also treated with rifaximin. Eradication was assessed 1 month after the end of therapy. Two dermatologists, unblinded on therapy, evaluated rosacea patients before and after treatment on the basis of an objective scale.

RESULTS:

The prevalence of SIBO was higher in patients than controls (52/113 vs 3/60, P < .001). After eradication, cutaneous lesions cleared in 20 of 28 and greatly improved in 6 of 28 patients, whereas patients treated with placebo remained unchanged (18/20) or worsened (2/20) (P < .001). Placebo patients were subsequently switched to rifaximin therapy, and SIBO was eradicated in 17 of 20 cases. Fifteen had a complete resolution of rosacea. After antibiotic therapy, 13 of 16 patients with negative BTs for SIBO remained unchanged, and this result differed from SIBO-positive cases (P < .001).

CONCLUSIONS:

This study demonstrated that rosacea patients have a significantly higher SIBO prevalence than controls. Moreover, eradication of SIBO induced an almost complete regression of their cutaneous lesions and maintained this excellent result for at least 9 months.

 

Colloidal oatmeal baths could be helpful, too. It's very easy to make and relatively cheap. Buy some oats, grind them to a fine powder and pour a couple cups in a bath:

 

 

A vastly diluted bleach bath is also helpful for some people with eczema:

 

http://www.newscient...ct-on-skin.html

http://www.aaaai.org...conditions.aspx

 

Topical vitamin B12 is worth exploring as well:

 

http://www.ncbi.nlm....pubmed/15149512

 

And applying cream and then covering the area in cellophane foil greatly helped this ichthyosis patient:

 



#150 SanjayK

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Posted 29 April 2014 - 01:14 AM

My general rule of thumb is the majority of problems you're facing will be MUCH better once you focus on healing the gut - Candida, SIBO, H. Pylori over growth etc..

 

Simply eliminating foods we have sensitivities too - gluten, dairy, eggs, soy, corn (it depends on YOU but for most of us traditional dairy and gluten are a problem) is another amazing "biohack".

 

Fixing these underlying problems has REALLY improved the quality of my life in just about every aspect - weight, mental health, focus, levelness of mood etc..






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