Dihexa: "it would take 10 million time...
jabowery
12 Sep 2014
I've placed the highest priority on obtaining such professional assistance. However, the results have been less than stellar. The best I've been able to accomplish in this regard is a Medicare-financed program where she is visited by a combination of specialists periodically to evaluate and provide some basic therapies. I've subjected every one of the 4 or 5 different specialists who visit her to my horror story about not being able to get a total functional capacity test done (I've gone through every avenue available to me to get a TFC done months in advance of starting dihexa to no avail), and to my insistence that they keep quantitative records on all variables they can for every visit -- compiled in some manner that they can be cross-correlated and longitudinally valid. I haven't yet requested that compilation in part because my opinion is that despite my admonitions I don't think much quantitative testing was done and I doubt that good records were kept even of subjective impressions....is there somebody who could see Jan every month or two to check on her progress?Jan's singing has objectively improved. She has not, in my subjective opinion, substantially improved in other areas...
Oh, and by the way, I am far from what you would call a fully-funded clinical trial here. We're broke (I have to stay at home to care for Jan and am receiving no compensation), so take that into consideration when you're suggesting obtaining outside help.
Edited by jabowery, 12 September 2014 - 12:38 AM.
Amorphous
12 Sep 2014
I ingested my first dose last night; here I am awake at around 4am and looking for things to do. I was thinking since this compound had a long half-life it wouldn't matter when I'd ingest it. Obviously, that was a wrong judgement. I am not tired but totally awake. I forgot where I saw the half-life of this compound. Was it 11 days or something? Anyone knows the volume of distribution of this compound? alpha, beta, and gamma phase elimination constant and half-life? I wonder what is the best dosing interval for this. I am planning to take another dose of around 25 mg this morning and will continue for about 3-5 days before changing to once a week for 1-2 month and then once a month thereafter. Any better suggestion of how to dose this compound?
medicineman
12 Sep 2014
Jan's singing has objectively improved. She has not, in my subjective opinion, substantially improved in other areas except perhaps in attitude and motivation to participate in Singing Coach practice. This, not being a double blind randomized clinical trial, etc. no strong conclusions may be drawn. The reemergence of her insomnia, after it had degenerated into hypersomnolence (serious enough that she was recommended for sleep study), is consistent with a "reversal" of sorts. Her improvement is consistent with training effect but if so it recommends Singing Coach as a treatment for Huntington's Disease if for no other reason than the improvements achievable from training boost morale.
From here I'm going to try to find a computer-based speech therapy system similar to Singing Coach. Jan's speech is hard to understand and it has a serious impact on her quality of life.
Details in the "spoiler" below:
Spoiler
I want to second that. It is unfortunate what Jan is going through, and I truly wish your diligence pays off, but she is lucky to have a partner like you. Keep the updates coming, am hoping to hear good news.
I think you should up the dosage and monitor BP. The drug is apparently very safe from what I'm reading, and I really think you must employ a salvage strategy with a little more aggressive dosing.
megatron
14 Sep 2014
It would be interesting getting an update from the person having used it for the longest period of time, DHEXA. Also, from the other persons having used it, do you feel like it increases your social intelligence or is it just verbal fluency? Do you feel like it's easier saying the "correct" things in different social situations?
xks201
14 Sep 2014
Amorphous
15 Sep 2014
The samples are being shipped in separate shipments now to N. Jabowery, fatigue to insomnia is a very interesting change. We will see what a 500mg to 1 gram loading dose does.
Wow, I had tried a 50mg dose once. My diastolic blood pressure went from 77 to 87 mmhg and I felt an headache. I'll definitely keep my dose below 50mg. Maybe you are okay with the 0.5 to 1g but it definitely is not for everyone.
Amorphous
16 Sep 2014
Just fyi 87 isn't hypertensive and I have never gotten a headache from it.
87 is within prehypertensive range, not yet hypertensive, but I need to be careful. From 77 to 87 is a big gap, I certainly felt a pressure in my headache and a medium headache. It lasted for about 4-5 hrs - I didn't time it exactly. Everyone is different, and I am glad you felt nothing. Dihexas (mm201) is an angiotensin IV agonist;
it can certainly bind to the AT2, AT3, and AT4 receptors to produce some kind of effects.
megatron
18 Sep 2014
Today I started my dihexa trial by administering 15mg dihexa sublingually dissolved in DMSO (I did of course swallow whatever didn't absorb sublingually, lol). The next five days I'm going to take 50mg / day, before moving on to 30mg / day. If I notice anything significant, I will report back as soon as I'm able to, if not probably around day 10 of using it.
Edited by Megatrone, 18 September 2014 - 05:11 PM.
resveratrol_guy
19 Sep 2014
Lumosity 1570 / increased by 50, but i doubt it's due to dihexa
WHOA! Hold on a sec here. You went from 1520 to 1570 in 3 days? Probably most members here aren't paying Lumosity members, so they don't know the significance of this. Since from your data it looks like you were stalled at 1520 for at least 3 days prior to the aforementioned 3 days, then I highly doubt this would happen unless you were drunk or stoned all those days (were you?) and caffeine-wired the last day (which you were, I believe). At my best and worst in the past month, I went up or down by 14 points, either way. And it's easier for me to improve than you, because you're closer to the neurological performance maximum (I'm 100+ points behind you). And BTW I strongly suspect that Lumosity is taking some sort of weighted historical average or otherwise smoothing out the data because I've done much better or much worse on some days, only to have my score barely budge in the expected direction.
So first, please verify that these numbers were correct. If possible, use your detailed training history to tell you (and us) how brain area performance scores changed to substantiate this delta. Screen shots are beautiful things.
You also mentioned: "One thing I noticed today while absorbing it, I was staring at wall. and felt that shades on wall is unusually solid. [stronger color perception?]" followed by: "Usually I couldn't remember exact phrases/words written in the book But I was able to recall all of phrases/words in few pages I read before sleeping yesterday." This sounds like a piracetam episode -- before the user demyelinates / stupifies / brainfogs a few months later. If this is really happening to you, then I truly hope that dihexa is not another piracetam. Some word memorization tests might be in order.
My theories, most likely first:
1. You made a typo or read the wrong numbers.
2. You sell dihexa.
3. Caffeine is more powerful than any of us ever imagined.
4. Dihexa has 2 phases of effect: short and long term. You just got jolted by the short term effect.
And finally, 2 outstanding TED videos here and here for those of us who want better memory by cheating neurology.
Edited by resveratrol_guy, 19 September 2014 - 01:14 AM.
christallire
20 Sep 2014
Lumosity 1570 / increased by 50, but i doubt it's due to dihexa
WHOA! Hold on a sec here. You went from 1520 to 1570 in 3 days? Probably most members here aren't paying Lumosity members, so they don't know the significance of this. Since from your data it looks like you were stalled at 1520 for at least 3 days prior to the aforementioned 3 days, then I highly doubt this would happen unless you were drunk or stoned all those days (were you?) and caffeine-wired the last day (which you were, I believe). At my best and worst in the past month, I went up or down by 14 points, either way. And it's easier for me to improve than you, because you're closer to the neurological performance maximum (I'm 100+ points behind you). And BTW I strongly suspect that Lumosity is taking some sort of weighted historical average or otherwise smoothing out the data because I've done much better or much worse on some days, only to have my score barely budge in the expected direction.
So first, please verify that these numbers were correct. If possible, use your detailed training history to tell you (and us) how brain area performance scores changed to substantiate this delta. Screen shots are beautiful things.
You also mentioned: "One thing I noticed today while absorbing it, I was staring at wall. and felt that shades on wall is unusually solid. [stronger color perception?]" followed by: "Usually I couldn't remember exact phrases/words written in the book But I was able to recall all of phrases/words in few pages I read before sleeping yesterday." This sounds like a piracetam episode -- before the user demyelinates / stupifies / brainfogs a few months later. If this is really happening to you, then I truly hope that dihexa is not another piracetam. Some word memorization tests might be in order.
My theories, most likely first:
1. You made a typo or read the wrong numbers.
2. You sell dihexa.
3. Caffeine is more powerful than any of us ever imagined.
4. Dihexa has 2 phases of effect: short and long term. You just got jolted by the short term effect.
And finally, 2 outstanding TED videos here and here for those of us who want better memory by cheating neurology.
1. No, I do not. it's 1 day improvement,
BTW, the 'just an artwork guy' i mentioned earlier, he kept played lumocity for few days and scored perfect score (> 0.1%) at every region.
he told me that lumocity is so much fun so he just played it over and over for few days. then boom, perfect score. WTH?
what do you mean by i'm 'closer to neurological performance maximum'? then what he will be? genius? i don't think so.
2. Nope
3. Probably
4. Maybe, I don't experiencing same thing since last post tho. BTW, I don't know what happened with piracetam episodes, BUT I am noticing some of following effects:
A. working memory definitely improved.
B. short term memory slightly impaired. I'm losing things what usually don't these days. wallet, cellphones. crap. thus I'm so shocked about demyelination you mentioned.
C. concentration improved. I usually cycling brainfog for approx. two weeks, and gone for approx. two weeks. then it starts again. I defined myself this effect as some sort of 'slump'. but since dihexa, it's all gone. just able to keep concentrating @ work.
D. things are well 'orchestrated' in mind. random input, organized output. getting good at work.
E. things are easy to remember for long time, but more forgetful for unimportant things. well, hmm.
Can you post a link to piracetam episodes? you scared hell out of me. :|
Edited by christallire, 20 September 2014 - 06:47 AM.
resveratrol_guy
20 Sep 2014
1. No, I do not. it's 1 day improvement,
BTW, the 'just an artwork guy' i mentioned earlier, he kept played lumocity for few days and scored perfect score (> 0.1%) at every region.
he told me that lumocity is so much fun so he just played it over and over for few days. then boom, perfect score. WTH?
what do you mean by i'm 'closer to neurological performance maximum'? then what he will be? genius? i don't think so.
2. Nope
3. Probably
4. Maybe, I don't experiencing same thing since last post tho. BTW, I don't know what happened with piracetam episodes, BUT I am noticing some of following effects:
A. working memory definitely improved.
B. short term memory slightly impaired. I'm losing things what usually don't these days. wallet, cellphones. crap. thus I'm so shocked about demyelination you mentioned.
C. concentration improved. I usually cycling brainfog for approx. two weeks, and gone for approx. two weeks. then it starts again. I defined myself this effect as some sort of 'slump'. but since dihexa, it's all gone. just able to keep concentrating @ work.
D. things are well 'orchestrated' in mind. random input, organized output. getting good at work.
E. things are easy to remember for long time, but more forgetful for unimportant things. well, hmm.
Can you post a link to piracetam episodes? you scared hell out of me. :|
Since I don't want to go too OT here, suffice to say: (1) use the search dialog at the upper right to look for piracetam (and other racetams); (2) read the threads thoroughly, not just the first few posts; and (3) demyelination is just one possible explanation for persistent failure, which might be avoidable if this poster is correct:
http://www.longecity...-to-work-for-me
That said, I only mentioned piracetam because your reported effects sound similar, which might indicate that similar neurological phenomena are occurring.
As to Lumosity scores: I've gotten perfect scores on some games as well, but nowhere near the top difficulty level. So "perfect score" doesn't mean much of anything. Peer ranking percentile for a given age group means volumes, however. At 1570 (or even 1520) you're on the high side already, even if you're 20. (You might considering telling us your age.) What I meany by "neurological performance maximum" is that your LPI is in the 1500s, whereas mine is in the 1400s; therefore I have more room for improvement than you do. That's why, for example, everyone experiences huge increases in LPI during the first few weeks of playing.
Have a look at "How You Compare" in your brain profile, which shows your age group at the top. Take a screen shot (usually PrtSc, Ctrl+PrtSc, Fn+PrtSc, or Shift+PrtSc). Copy it to the clipboard, then paste it into a paint program (ideally) or a word processor. Save it and upload it here as an attachment to your reply. The line graph in "Detailed Training History" would also provide useful data.
I'm interested by your observation that painters seem to have excellent memory according to Lumosity. It kind of makes sense, considering how they need to visualize what they're painting, especially since most of the Lumosity memory tests are heavily visual. Ironic, isn't it, considering the amount of volatile organic compounds that even oil painters inhale?
So based on your A/B/C/D/E effects, it sounds like dihexa is causing you to do a better job of focussing on important tasks, while losing track of trivial stuff. I would not consider the loss of short term memory for where you put your phone or keys alarming, provided that it's because you're focussing internally on bigger problems. Einstein often lost his way home because he was thinking about general relativity. OTOH if you're focussing on getting ready to go out, and you end up wearing the wrong clothes or leaving your keys on the table, then we have something more akin to dementia.
Now one thing I find inexplicable is why you are seeing any effects at all. I mean, the title of this thread says it all: we're talking about synapse formation (equivalently, causing enough dendrite growth that the average axon experiences an increase in dendritic gaps close enough to communicate with it); an increase in dendritic pore coupling would also be an expected result. But can we really have that much synapse formation in a couple weeks, to produce the effects you're seeing? Yes, dramatic effects can sometimes happen in a few days with direct stem cell injection into the affected brain regions in a stroke victim, but you're taking a drug which presumably effects the entire brain. So you're growing a dendrite network as fast as I'm growing a beard? If that's really true, then we have bona fide brain regeneration here. Which is why I'm very skeptical. I suspect that if you're really being honest with us (please don't forget those screen shots), then there's a short term effect going on that has nothing to do with the rat studies (which did indeed show that dihexa was worse than saline in rats who had not been poisoned by scopolamine, as another poster pointed out). So perhaps you've stumbled upon something very valuable that has nothing to do with synapse formation. We need lots more data.
Since you're having trouble remembering trivial stuff, did I mention that you might want to include some screen shots? You might be the best-analyzed human on the planet at the moment with respect to discerning the effects of dihexa, courtesy of Lumosity. So next time you see your refrigerator, you'll remember to send some screen shots.
Edited by resveratrol_guy, 20 September 2014 - 03:56 PM.
christallire
21 Sep 2014
1. No, I do not. it's 1 day improvement,
BTW, the 'just an artwork guy' i mentioned earlier, he kept played lumocity for few days and scored perfect score (> 0.1%) at every region.
he told me that lumocity is so much fun so he just played it over and over for few days. then boom, perfect score. WTH?
what do you mean by i'm 'closer to neurological performance maximum'? then what he will be? genius? i don't think so.
2. Nope
3. Probably
4. Maybe, I don't experiencing same thing since last post tho. BTW, I don't know what happened with piracetam episodes, BUT I am noticing some of following effects:
A. working memory definitely improved.
B. short term memory slightly impaired. I'm losing things what usually don't these days. wallet, cellphones. crap. thus I'm so shocked about demyelination you mentioned.
C. concentration improved. I usually cycling brainfog for approx. two weeks, and gone for approx. two weeks. then it starts again. I defined myself this effect as some sort of 'slump'. but since dihexa, it's all gone. just able to keep concentrating @ work.
D. things are well 'orchestrated' in mind. random input, organized output. getting good at work.
E. things are easy to remember for long time, but more forgetful for unimportant things. well, hmm.
Can you post a link to piracetam episodes? you scared hell out of me. :|
Since I don't want to go too OT here, suffice to say: (1) use the search dialog at the upper right to look for piracetam (and other racetams); (2) read the threads thoroughly, not just the first few posts; and (3) demyelination is just one possible explanation for persistent failure, which might be avoidable if this poster is correct:
http://www.longecity...-to-work-for-me
That said, I only mentioned piracetam because your reported effects sound similar, which might indicate that similar neurological phenomena are occurring.
As to Lumosity scores: I've gotten perfect scores on some games as well, but nowhere near the top difficulty level. So "perfect score" doesn't mean much of anything. Peer ranking percentile for a given age group means volumes, however. At 1570 (or even 1520) you're on the high side already, even if you're 20. (You might considering telling us your age.) What I meany by "neurological performance maximum" is that your LPI is in the 1500s, whereas mine is in the 1400s; therefore I have more room for improvement than you do. That's why, for example, everyone experiences huge increases in LPI during the first few weeks of playing.
Have a look at "How You Compare" in your brain profile, which shows your age group at the top. Take a screen shot (usually PrtSc, Ctrl+PrtSc, Fn+PrtSc, or Shift+PrtSc). Copy it to the clipboard, then paste it into a paint program (ideally) or a word processor. Save it and upload it here as an attachment to your reply. The line graph in "Detailed Training History" would also provide useful data.
I'm interested by your observation that painters seem to have excellent memory according to Lumosity. It kind of makes sense, considering how they need to visualize what they're painting, especially since most of the Lumosity memory tests are heavily visual. Ironic, isn't it, considering the amount of volatile organic compounds that even oil painters inhale?
So based on your A/B/C/D/E effects, it sounds like dihexa is causing you to do a better job of focussing on important tasks, while losing track of trivial stuff. I would not consider the loss of short term memory for where you put your phone or keys alarming, provided that it's because you're focussing internally on bigger problems. Einstein often lost his way home because he was thinking about general relativity. OTOH if you're focussing on getting ready to go out, and you end up wearing the wrong clothes or leaving your keys on the table, then we have something more akin to dementia.
Now one thing I find inexplicable is why you are seeing any effects at all. I mean, the title of this thread says it all: we're talking about synapse formation (equivalently, causing enough dendrite growth that the average axon experiences an increase in dendritic gaps close enough to communicate with it); an increase in dendritic pore coupling would also be an expected result. But can we really have that much synapse formation in a couple weeks, to produce the effects you're seeing? Yes, dramatic effects can sometimes happen in a few days with direct stem cell injection into the affected brain regions in a stroke victim, but you're taking a drug which presumably effects the entire brain. So you're growing a dendrite network as fast as I'm growing a beard? If that's really true, then we have bona fide brain regeneration here. Which is why I'm very skeptical. I suspect that if you're really being honest with us (please don't forget those screen shots), then there's a short term effect going on that has nothing to do with the rat studies (which did indeed show that dihexa was worse than saline in rats who had not been poisoned by scopolamine, as another poster pointed out). So perhaps you've stumbled upon something very valuable that has nothing to do with synapse formation. We need lots more data.
Since you're having trouble remembering trivial stuff, did I mention that you might want to include some screen shots? You might be the best-analyzed human on the planet at the moment with respect to discerning the effects of dihexa, courtesy of Lumosity. So next time you see your refrigerator, you'll remember to send some screen shots.
Thank you for such a long post.
I have to go out soon, so i'll just post screenshots since you so much eager to see it, to prove my honesty :d
As you can see in my screenshot, i don't playing it anymore (i'm really busy these days) and history graph is bit odd but in detailed history i did it in 1 day
And, you might noticed that I had baseline test before taking it.
I'll post 'just an artwork guy's perfect score' screenshot soon. he's younger than me for 4 years and I was born at 1985, and I'm a computer programmer (you have to see problem solving score, it's my lowest region, :$ )
I don't know, can we call this effect as dramatic effect? well, I'll rather say i had dramatic effect when I developed eidetic memory, LOL
FYI, i'm not taking dihexa alone, taking Choline, Uridine, DHA regimen and Lions mane too (you can see what exactly i'm taking with in my previous post)
Attached Files
Edited by christallire, 21 September 2014 - 05:57 AM.
resveratrol_guy
21 Sep 2014
Thanks for that. So it looks like you went from 1526 to 1570, in one day. That's incredible! I cannot find any inconsistencies in your screen shots which suggest that you faked the data. (For future purposes, in the line graph chart, please click on the individual categories at the top so we can see all the regional trends.) Maybe I am indeed underestimating the benefits of caffeine. It's hard to know, with only 2 data points. The longer you go without training, the noisier the numbers get, because you start to forget your techniques and need to retrain. So if possible, please help us out by playing daily if you're able to. I play in the morning before I ingest anything, in order to filter out short term effects like caffeine.
But I can't just trump this up to a few cups of coffee on your part, on account of your other reported experiences. Your data creates a lot more questions than it answers.
Independent of dihexa, though, you must be doing something right (maybe your other supplements moreso than your DNA): while your memory performance is absolutely outrageous, it's actually your 91% attention score that pops out at me. I think, of all the scores, attention is the best measure of brain health, because it measures how you use all of your mental faculties to respond to a dynamically evolving situation, rather like an air traffic controller. While I've been able to use my existing supplements and also some memory tricks to keep my memory scores high, I haven't been able to do much to improve attention (which might better be called "response rapidity"). This theory seems to be consistent with the neurological observation that the hardest brain function to improve in older individuals is time-to-recall. And note that "problem solving", as far as I can see, is a measure of how fast you can do arithmetic -- not how well you deal with abstract problems. So I think it's actually the least important function because it's entirely replacable with a computer with no significant loss to quality of life. So a low problem solving score is not in conflict with the improved real-world-problem-solving performance that you reported.
Edited by resveratrol_guy, 21 September 2014 - 01:42 PM.
StevesPetRat
22 Sep 2014
Oh, and by the way, I am far from what you would call a fully-funded clinical trial here. We're broke (I have to stay at home to care for Jan and am receiving no compensation), so take that into consideration when you're suggesting obtaining outside help.
Oh, hey, I actually meant a semi-objective friend or acquaintance who could pop in once in a while for a chat rather than one of those "professionals", I don't necessarily obsess over "objective measurements for the benefit of humanity" or whatever grandiosity (though I do of course appreciate the time you are already taking to log all your personal results). Just thought somebody like that might be better able to see gradual improvements that you might miss in the day-to-day ups and downs, and offer a word of encouragement when appropriate.
Edited by StevesPetRat, 22 September 2014 - 12:18 AM.
X_Danny_X
22 Sep 2014
Thanks for that. So it looks like you went from 1526 to 1570, in one day. That's incredible! I cannot find any inconsistencies in your screen shots which suggest that you faked the data. (For future purposes, in the line graph chart, please click on the individual categories at the top so we can see all the regional trends.) Maybe I am indeed underestimating the benefits of caffeine. It's hard to know, with only 2 data points. The longer you go without training, the noisier the numbers get, because you start to forget your techniques and need to retrain. So if possible, please help us out by playing daily if you're able to. I play in the morning before I ingest anything, in order to filter out short term effects like caffeine.
But I can't just trump this up to a few cups of coffee on your part, on account of your other reported experiences. Your data creates a lot more questions than it answers.
Independent of dihexa, though, you must be doing something right (maybe your other supplements moreso than your DNA): while your memory performance is absolutely outrageous, it's actually your 91% attention score that pops out at me. I think, of all the scores, attention is the best measure of brain health, because it measures how you use all of your mental faculties to respond to a dynamically evolving situation, rather like an air traffic controller. While I've been able to use my existing supplements and also some memory tricks to keep my memory scores high, I haven't been able to do much to improve attention (which might better be called "response rapidity"). This theory seems to be consistent with the neurological observation that the hardest brain function to improve in older individuals is time-to-recall. And note that "problem solving", as far as I can see, is a measure of how fast you can do arithmetic -- not how well you deal with abstract problems. So I think it's actually the least important function because it's entirely replacable with a computer with no significant loss to quality of life. So a low problem solving score is not in conflict with the improved real-world-problem-solving performance that you reported.
so this guy Christinelire, increase his intelligence with just caffeine??? i dont normally agree with Lumnosity games in increasing intelligence since I think you just become good at playing a game, not increasing intelligence. The only true game that helped me increase intelligence is DUAL N BACK!
jabowery
22 Sep 2014
Oh, hey, I actually meant a semi-objective friend or acquaintance who could pop in once in a while for a chat ... Just thought somebody like that might be better able to see gradual improvements that you might miss in the day-to-day ups and downs, and offer a word of encouragement when appropriate.
Thanks for pointing that out. That is practical and useful. In fact one of the practical realities of a Huntington's household is social isolation so virtually all our social contacts are of an occasional nature. I'll be sure to inquire.
xks201
23 Sep 2014
xks201
23 Sep 2014
xks201
23 Sep 2014
X_Danny_X
23 Sep 2014
700mg knocked me out and behaved sort of like a high dose of human growth hormone. I woke up now in a state of hyperfocus....tunnel focus. Feels like my brain is like ten times more capable than my body. This behaves very different at 700mg than even 50mg. It feels as if my brain is being rewired. I have zero trace of adhd which I have had severely for a while. I don't recommend anyone go over like 40mg until I figure out what exactly is happening here. It is extremely intense, almost like a psychedelic high without the hallucinations....how I described it to N is it feels like my brain is a one thousand pound paper weight over whatever train of thought I am having. It feels like an extreme parasympathetic stimulant. Not like a traditional stimulant....This is unlike anytjing I've seen before ...not even close. I'm not sure whether to rejoice or what at this moment as the hyperfocus Is ridiculous.
this feels to what Ritalin made me feel. i was sooooooooo focus and willing to do work. im not too sure if you are getting a high dose of dopamine release or anything else that does what dopamine does.
anyway, im kind of interested in this.....seems very promising. though i fear people will get insomnia
Edited by X_Danny_X, 23 September 2014 - 01:25 PM.
ceridwen
23 Sep 2014
ceridwen
23 Sep 2014
I need this. I've been seriously contemplating killing myself this might make me change my mind! Here's hoping it halts the decline and not just a temporary thing
megatron
23 Sep 2014
700mg knocked me out and behaved sort of like a high dose of human growth hormone. I woke up now in a state of hyperfocus....tunnel focus. Feels like my brain is like ten times more capable than my body. This behaves very different at 700mg than even 50mg. It feels as if my brain is being rewired. I have zero trace of adhd which I have had severely for a while. I don't recommend anyone go over like 40mg until I figure out what exactly is happening here. It is extremely intense, almost like a psychedelic high without the hallucinations....how I described it to N is it feels like my brain is a one thousand pound paper weight over whatever train of thought I am having. It feels like an extreme parasympathetic stimulant. Not like a traditional stimulant....This is unlike anytjing I've seen before ...not even close. I'm not sure whether to rejoice or what at this moment as the hyperfocus Is ridiculous.
This was taken orally? So, you've taken 1200mg in one day?
Edited by Megatrone, 23 September 2014 - 03:11 PM.
DHEXA
23 Sep 2014
I've been off of dihexa for 35 days. No withdrawl or dependence noticed upon cessation. I ended up taking ~27mg daily for around 40 days.
700mg knocked me out and behaved sort of like a high dose of human growth hormone. I woke up now in a state of hyperfocus....tunnel focus. Feels like my brain is like ten times more capable than my body. This behaves very different at 700mg than even 50mg. It feels as if my brain is being rewired. I have zero trace of adhd which I have had severely for a while. I don't recommend anyone go over like 40mg until I figure out what exactly is happening here. It is extremely intense, almost like a psychedelic high without the hallucinations....how I described it to N is it feels like my brain is a one thousand pound paper weight over whatever train of thought I am having. It feels like an extreme parasympathetic stimulant. Not like a traditional stimulant....This is unlike anytjing I've seen before ...not even close. I'm not sure whether to rejoice or what at this moment as the hyperfocus Is ridiculous.
This was taken orally? So, you've taken 1200mg in one day?
This seems rather reckless. What is the rationale for these doses?
resveratrol_guy
23 Sep 2014
so this guy Christinelire, increase his intelligence with just caffeine??? i dont normally agree with Lumnosity games in increasing intelligence since I think you just become good at playing a game, not increasing intelligence. The only true game that helped me increase intelligence is DUAL N BACK!
Caffeine surely helped, but we don't have enough data to know how much. Moreover, he claims that he's observed a general enhancement in mental performance as he outlined above, entirely apart from his one great Lumosity session (with no further sessions since). Lumosity is marketed as a "brain gym", but I think its real value is as a relatively objective assessment of mental performance. And although there is certainly a training effect resulting in improvement in scores, this ceases to apply after a month or two. His scores seemed to be flat enough that a one-day jump to 1570 would have been very unlikely, caffeine or not.
So pending more data, we have no good grasp of dihexa's role here.
BTW the BBC actually did a study of brain games with Cambridge Brain Sciences (in this video) wherein they found that several weeks of training were barely better than browsing the Web in order to answer obscure questions for the same amount of time. So they claim to have debunked brain games as a vehicle for mental improvement. But what they actually debunked was the economic utility of brain games, because both experimental and control groups showed improvement on a variety of cognitive tests, albeit a small one. But with 11,430 participants, the small change appears to have high statistical significance. (The control group should probably have been required to watch made-for-TV dramas or some such vacuity.)
resveratrol_guy
23 Sep 2014
700mg knocked me out and behaved sort of like a high dose of human growth hormone. I woke up now in a state of hyperfocus....tunnel focus. Feels like my brain is like ten times more capable than my body. This behaves very different at 700mg than even 50mg. It feels as if my brain is being rewired. I have zero trace of adhd which I have had severely for a while. I don't recommend anyone go over like 40mg until I figure out what exactly is happening here. It is extremely intense, almost like a psychedelic high without the hallucinations....how I described it to N is it feels like my brain is a one thousand pound paper weight over whatever train of thought I am having. It feels like an extreme parasympathetic stimulant. Not like a traditional stimulant....This is unlike anytjing I've seen before ...not even close. I'm not sure whether to rejoice or what at this moment as the hyperfocus Is ridiculous.
While I agree that 700 mg is reckless, you did in fact do it so I think you deserve considerable gratitude. So is there any quantitative mental characterization data you can offer us while in this state, now that you've already taken this risk? Or even observations like feeling less creative despite being more focussed, or more linguistically competent at the expense of math competence, etc.
I think it's increasingly clear that dihexa has a short term effect which has nothing to do with synaptic population increase.
Edited by resveratrol_guy, 23 September 2014 - 04:30 PM.
VERITAS INCORRUPTUS
23 Sep 2014
Yeah, in that dopamine feels great
...and does provide for most cognitive improvement.
Seriously though, this may very well be what is entirely at play here, within a potent modulation of dopaminergic tone.
The 'tone' of what was related seems very much within this spectrum.