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Would like suggestions to reverse drug induced brain damage


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#1 Anewlife

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Posted 18 December 2012 - 12:20 PM


Currently I am on a short course of low dose anti psychotics due to steroid induced psychosis after dianabol depleted all my serotonin.

It was a major introspective moment for me and realised I need to turn my life around or I will die before I turn 40 from self neglect.

I am not hoping for any pity but I hope this motivates people here to push through whatever they are going through now. My story is years ago I binged on drugs for a few months after trying to fill the void of devestating heart break, as I have a neurotic disposition I went to a hellish place in my mind coming off those drugs where I experimented under the effects of a self induced chemical lobotomy not long after I was diagnosed with a terminal illness and survived, due to these events I have been somewhat disconnected in life and withdrawn, after the diagnoses I did something stupid and self medicated with testosterone to feel better but was still withdrawn, this is a regretful decision because I have neglected my own health, I think a lot of my problems stem from impulsiveness which I have always had due to poor diet and upbringing I guess.

Right now I am at rock bottom in my life I look sick, I dont socialize, I have slowly developped a blunted effect, I am smoking 2 packets of cigarettes a day.
I hate to say it but I have wasted 6 years of my life, before this I had wasted one being a natural introvert.

The thing is I can do A LOT more with my life, I have spent the past couple of years reading up on social science and psychology and it has helped me realise the problems of my environment and my own weaknesses.

Right now I absolutely NEED to turn my life around before I turn myself in to a vegetable, I may seem coherent but as I am now I am socially disabled, I know I can improve on my mental health but my 2 scariest problems which I think some of you could help me with are these:

1) Dissociation, losing track of time, time goes by too fast possibly due to OCD, possibly PTSD, both can be overcome by improving on anxiety and mental health I am told.

2) This may be due to ecstasy use, this is kind of hard to explain, it could be blunted affect, or something not firing right in my brain, it could also be PTSD, I will be talking to someone and recall a memory from years ago or ask a question about someone and I will unintentionly look down depressed, this is embarassing because I have done it at socially inappropriate times, it is impossible for me to fake being happy. It is like a tick, its as though something needs to fire in my brain and it just doesnt happen and instead I look down and put my chin down.
This really feels like brain damage.

I can study with Inositol+Choline.
I took a lot of fish oil after my drug use which helped.


TL;DR

Right now I have a 6 month plan to get myself mentally healthy, starting with aerobic exercise and more frequent CBT and quiting smoking.
I have been seeing a senior psychologist who believes most my issues stem from anxiety and severe OCD.

What I want help with here is suppliments which can supposedly reverse brain damage. I am not looking for neuroenhancers or protecterants but rather just something to heal.

This is my current list:
Vit C 1g 4x day for adrenals
inositol+choline for concerntration
lecithin may cause brain damage
glutamine for gaba
flax oil + fish oil
olive oil anti inflamitory
multi vitamin
magnesium I have a deficiency

avocados contain tryptophan
blueberries
oranges for phytos
apple a day

For the brain damage:
BCAA- Leucine, Isoleucine, Valine shown to reverse brain damage
Ginkgo I will cycle this
vinpocetine
huperzine A heard something negative on here about these 2

Things I am unsure about:
acetyl-l-carnitine
ALA
n-acetyle-Cysteine


I am concerned about taking nootropics as I dont want to be dependant on anything that forcefully changes my brain chemistry, I want to rewire my brain and let my neurons and axons and such develop themselves if possible.

Edited by Anewlife, 18 December 2012 - 12:30 PM.


#2 evo

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Posted 18 December 2012 - 12:53 PM

When did you supplement with testosterone, and when did you notice the symptoms start to worsen?

I don't know how old you were when you made these decisions, but if your endocrine system was not fully developed, it's quite possible you never bounced back and/or threw things off balance more permanently. It's possible to recover HPTA function but the current standard treatment is TRT which would be (as of now) lifelong. If this DOES turn out to be the case (and you should not assume this without the proper lab work) you might also want to ask your doctor about clomiphene (first option) and naltrexone (less desirable, but strongly effective in reviving LH production)

Before you draw any conclusions you should really have some blood tests done to check for abnormalities. Nevertheless it does seem likely that damage could occur if a proper PCT was not followed with the effects compounded severely by stress and drug abuse.

The first thing you really need to do is see a doctor to have these basic tests done; if these don't reveal a cause, at the very least I can tell you the nicotine is severely compounding any anxiety you may have. You MIGHT see some benefit from Cerebrolysin relative to its regenerative effects, but under no circumstances should you use any while you're still smoking--it will just make things worse.

Edited by lmlj, 18 December 2012 - 01:00 PM.


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#3 Anewlife

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Posted 18 December 2012 - 01:27 PM

I was 24 when i started, I am 29 now, the testosterone has been on and off, I wish I had never taken any exogenous hormones or drugs.

I am currently on Arimidex to recover my HPTA function. I have never been fully shutdown before.

After doing more reading here I have decided to add turmeric and gotu kola.

I dont want to take Cerebrolysin, no more drugs or hormones for me, I want my body to reach homeostasis and recover, I learnt a hard lesson with TRT and now with dianabol.
To give an idea why, my doctor told me not to take TRT I will want more etc, I read online to take it because of my T levels which were in the middle but lowish for my age, that I can take arimidex, HCG and will be fine, years later things have deteriorated, it has aged me, TRT reduces collagen production moreso than smoking, what I really need is to heal my brain.

#4 Keshan

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Posted 18 December 2012 - 01:40 PM

I would:
-Add a good multivitamin
-Recommend looking into racetams (for anxiety)
-Add Creatine (for brain and muscle health)
-Add ALCAR (acethyl-l-carnitine)
-Add Vitamin D, supposedly protects your lung if smoking

#5 sunshinefrost

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Posted 18 December 2012 - 01:40 PM

Rewirering your brain ? easy.... cerebrolysin or Cebria. Good luck

#6 renfr

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Posted 18 December 2012 - 02:02 PM

I can study with Inositol+Choline.

Have you experienced a significant memory boost with that combo?

lecithin may cause brain damage

What? Maybe GMO lecithin does, but non GMO lecithin is in fact good for brain health as it contains omegas and phosphatidylcholine.

You should try restoring your serotonin levels back to what they were before ecstasy use, XTC can cause permanent brain damage due to serotonin depletion but if you handle the depletion before neuroplasticity changes permanently your mental structures you could get away from the damage.
Do you have short term memory loss or severe memory lapses? If you do then you likely have a serotonin deficiency. (serotonin selectively impairs short term memory)
Bacopa, caffeine and withdrawing from XTC with 5HTP might be a good idea.
I'm saying XTC because this is what you took but it could happen with any other serotonergic agonist.

#7 Anewlife

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Posted 18 December 2012 - 02:30 PM

Considerable cognitive boost while on inositol+choline. 125mg of each before a study session.

Caffeine isnt good for anxiety or the adrenals I just quit it.

I pretty much want to reverse this:
http://faculty.washi.../gif/5htctx.jpg

In the prefrontal and cerebral cortex that it supposedly does.

Edited by Anewlife, 18 December 2012 - 02:31 PM.


#8 renfr

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Posted 18 December 2012 - 03:31 PM

Considerable cognitive boost while on inositol+choline. 125mg of each before a study session.

Caffeine isnt good for anxiety or the adrenals I just quit it.

I pretty much want to reverse this:
http://faculty.washi.../gif/5htctx.jpg

In the prefrontal and cerebral cortex that it supposedly does.

Gosh, that's extremely scary. Is that from a single use?

Good to hear that combo is good for cognitive boost, you should indeed supplement choline, there is an inverse relationship between acetylcholine and serotonin and it causes on long term upregulation of serotonin receptors :

Brain serotonin turnover is increased following administration of cholinesterase inhibitors, including carbamates (physostigmine) as well as organophosphates (OPs) (including soman) (Prioux-Guyonneau, Coudray-Lucas, et al., 1982; Pscheidt, Votava, and Himwich, 1967; Kleinrok, Jagiello-Wojtowicz, and Sieklucka, 1975; Haubrich and Reid, 1972; Rausch, Janowsky, et al., 1985). These effects differed in different parts of the brain, being strongest in the striatum, present in most areas of the brain, but absent in the hypothalamus in one study (Prioux-Guyonneau, Coudray-Lucas, et al., 1982).


I know how it feels to feel brain damaged due to serotonin depletion, I experience that after psychedelic comedown.

Anyway good luck mate.

Edited by renfr, 18 December 2012 - 03:32 PM.


#9 Anewlife

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Posted 18 December 2012 - 04:15 PM

Thanks, how did recovery go for you?

I dont like saying this cause it starts an argument about ecstasy long term effects, the way I see it MDMA may not cause long term effects but ecstacy = pill cocktail normally.

A good friend of mine has never been the same since taking ecstasy on only 1-3 occasions, he is less sharp, ego sensitive and is socially retarded when drunk (same as me).

But I know another person who went crazy on pills, taking them like candy at home, 5 at a time by himself and now he is a mental wreck.

The 1st guy is normal and healthy, gets sunlight, works, exercises, doesnt smoke, but drinks every weekend, and its been years and he isnt 100% maybe due to the alcohol.

The 2nd guy went to a care/rehab centre for a while.

I think treating it as physical brain damage is the right way to go about it.
I am reading up on hyperbaric oxygen treatment http://www.ncbi.nlm....pubmed/22146562

Also neuroplasticity which isa buzz word does not mean your brain wires itself a certain way while healing, it means its constantly capable of rewiring itself, which is the truth, you can rewire for introversion or extroversion, reading comprehension, etc.

Its obvious if you know people who have changed fields such as from a desk job to a sales job or from a social job to a job of authority, people take their attitudes from work with them somewhat or atleast skills.

Edited by Anewlife, 18 December 2012 - 04:16 PM.


#10 Galaxyshock

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Posted 18 December 2012 - 04:32 PM

Could D-aspartic acid help for HPTA function?
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#11 Anewlife

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Posted 18 December 2012 - 04:40 PM

HPTA function will recover with PCT and time. I was on TRT for about 2 years, came off with no PCT as I wasnt completely shut down and everything was back to normal.

#12 chairofgold

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Posted 18 December 2012 - 07:31 PM

The best regime for brain repair would be;

1) Cerebrolysin

2) Lion's Mane

3) Acetyl L-Carnatine Arginate

4) Gotu Kola

Use all of these together. They all cause dendrite growth with Cerebrolysin being the most potent of all four.

#13 Anewlife

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Posted 07 July 2013 - 06:53 PM

An update, I have improved a lot in the past few months, I attribute this mainly to meditation but I am now seeing a greater speed of improvement with exercise and 3rdly NAC that I have both recently begun.

I read somewhere that meditation increases volume of the brain stem and other areas of the brain and also increases connections between ALL areas of the brain.
For those interested I am not sure if its in this link somewhere but good reading none the less http://io9.com/how-m...eel-b-470030863

Edited by Anewlife, 07 July 2013 - 06:53 PM.

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#14 KoolK3n

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Posted 07 July 2013 - 10:40 PM

I'm glad everything's working out for you. What's your NAC dosage? Continue exercising and make sure to socialize 24/7 whenever possible. Maybe you can workout with a friend.

Edited by KoolK3n, 07 July 2013 - 10:41 PM.


#15 Anewlife

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Posted 07 July 2013 - 11:55 PM

Thanks, my nac dosage is 600mg twice a day and I am part of 2 new communities where I socialise.

#16 Major Legend

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Posted 08 July 2013 - 05:59 AM

I really can't understand how MDMA is not considered as mentally toxic by consensus. The stuff is practically eating poison, sure there is no feeling like it, but its the only illegal drug I can think of thats dangerous to take weekly, or even a few times a year for those who want to keep total mental clarity. When I was younger i've done a lot of drugs, and there is nothing that can burn your brain like pure MDMA. I've had entire things wiped from my mind, like forgetting a long remembered name or password.

Think about it - a drug that you take "normal dosage" weekly is enough to make you stupid - what kind of drug can do that? You can take methamphetamine and amphetamine on a DAILY basis and still retain most cognitive function. I would prefer the neurotoxicity of methamphetamine over MDMA if I had to choose. MDMA is the most amazing drug in the world, and nothing can take that away - but its something that in my opinion you should only try once or twice in your life AT MOST.

Everyone I know who has persisted in doing MDMA, or have a history of doing it frequently have difficulty with stuff like calculation, basic maths, common sense, less sharpness, I guess more silly (in a good way). Fortunately my exposure was relatively limited, my brain damage was from another incident - not related to MDMA, though i'm 100% sure MDMA did have damaging effects on my overall brain power. Also due to "cognitive reserve" young people are far less likely to notice the damage they are making until years down the line - when their brains will literally age faster than other people unexposed to MDMA.

As I said in another thread - there is no drug as bad as MDMA for brain health (since this is the topic of this particular forum).

Again I find it surprising that there are lots of people out there who believes MDMA is harmless, and no general scientific consensus of how much damage it does with the serotonin system, there is even research on micro dosing MDMA for depression.

Anewlife, I don't understand how you ended up on dianabol as a drug for recreational use. Its not a drug you are supposed to take for more than 2 weeks anyways steroid cycler suggest switching that to another form after 2 weeks (from memory),

Yes there is a host of things you can take. For a non-injection intervention I would suggest noopept over lions mane, however recovery takes time and you will probably never fully recover but I think 90% or so for me is better than not regenerating at all.

Edited by Major Legend, 08 July 2013 - 06:04 AM.

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#17 Anewlife

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Posted 08 July 2013 - 11:34 AM

MDA burns ur brain more then MDMA imo I have done both and MDA is way more intense with a fucked up come down.

#18 pmz

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Posted 29 September 2013 - 02:23 AM

Any new update? I can definitely relate

#19 Anewlife

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Posted 15 August 2014 - 06:13 PM

Update on this.

I was on too high a dose of anti-psychotics. So apparently if you are depressed on APs it just means you are on too high of a dose. The drugs arnt so bad cognitively. The bad part is from physical problems such as diabetes and sex drive.

 

It was pretty cool not giving a fuck but after coming off it was a slow process going back to my old self.

Astaxanthin seemed to kick start things last month. I made another thread on it.

 

From what I gather my guess is that regarding psychiatric meds, if the dose is wrong and lowers your functioning it will lead to deterioration. If whatever med is helping you socialize etc it will have a positive effect on the brain. So for example if you are high inhibition and go on Valium it should cause positive changes. When you come off it you should remain desensitized due to experiential exposure to whatever you were inhibited to.

 

I am booked in at a private neurology research clinic, bought some books on rewiring the brain through CBT. Also getting my nutrients tested and supplemented.

 

I am dependant on a few substances:

Tobacco

Coffee

Sertraline

Occasional codeine

 

I can train myself cognitively quite easily I am just finding it very hard to reduce impulsiveness, improve mood and motivation. I need to look in to it further.

 

I got a box of modafinil for a sleep disorder but I am not allowed to take it because it could turn me schizophrenic, but I know I could easily smash out a masters degree on it but I have decided to stay out of uni and I actually wanna become dumber. I want to improve my mood now not cognition. Think less, care less but be higher functioning athletically and socially.

 

Also I have discovered coconut oil (use unrefined, virgin cold pressed only). It seems superior to choline. Improves attention so you can just sit and read a book.

I have never been able to read so well. I dont go over sentences any more and I am reading faster.

 

I recomend:

A course of astaxanthin(4mg a day max) and beta-carotene (12-25mg a day)

1gram of coconut oil a day.

 

 

 


Edited by Anewlife, 15 August 2014 - 06:19 PM.

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#20 Flex

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Posted 15 August 2014 - 10:23 PM

As far as I know, an in some degree related scientific term to rewire the brain, could be "Neurorestorative"

Type this in NCBI and You´ll get some results.

To set the brain back as before, You have sometimes much to learn which could be even dangerous* and at the end is of course no guarantee for success

* I have the feeling that I here and then nearly had an Intracranial hemorrhage because of mixing bloodthinning stuff

(Herbals & etc. and yeah.. I fucked myself up with Ethylphenidate through my "half-knowledge")

My way lasts allready 6 years.. Dont know whether I´m ineffective or the topic is too complicated and I just dont had a propper support to learn this.

 

Anyway, I´ve made 2 threads with infos of various nootropics in the hope to move something or help somebody, at least, a bit.

Newly natural compounds that I´ve found with interresting effects

http://www.longecity...639#entry681639

Brainrepair Topic

http://www.longecity...inrepair-topic/

 

Dont know whether You just need to use the Antipsychotics and I dont want to play a Doctor,

but they have been shown to be harmful. So I would use them only if there is no other way

Here is a thread regarding it:

http://www.longecity...ot/#entry681573

 

Btw: If You are interrested, I´ve posted somewhere natural antipsychotics with references like:

Stepholidine and Tetrahydropalmatine but cant currently find this thread

 

Wish the Best

 


Edited by Flex, 15 August 2014 - 10:27 PM.

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#21 kurdishfella

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Posted 26 June 2022 - 11:16 AM

You can't induce brain damage with drugs unless it is in a poisonous overdose. What you call damage is just brain plasticity change which goes back to how you are.

small things break easier and drugs manufacturers are one of the smallest things you make


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