24 replies to this topic

[JohnnyP]

Hey everybody considering the number of benefits of supplementing with Forskolin, it is increasing my desire to do so. Unfortunately a few years back I took a supplement containing Forskolin and its effects it had on overall body composition etc. were great but it gave me some serious digestive issues that had me in bathroom a little too much for my liking lol. So my question is for anybody who may have experienced anything similar is there any way to prevent it or at least help to make it a little better? Thanks in advance.

[Guardian4981]

You state you took something that contained it, so how do you know it was the forskolin?

I have taken forskolin and never have digestive issues, biggest issue I have with forskolin is lower blood sugar and too much vasodilation, though I still try to use it regularly.

[JohnnyP]

I don't mean to argue so don't take it the wrong way but I figured it was the Forskolin because it is the first ingredient listed, the issues went away when I stopped using it, and the other ingredients included fadogia, and vitamin D. When doing a search on the internet (not the best source I know) Forskolin had some reports of digestive issues. I wasn't trying to tell anybody to stay away from it or to give the supp a bad name I was just wondering if anybody had any advice from a similar experience.

[niner]

The first thing I would try is a different source, preferably of high purity. You could try a lower dose, or spread the dose out throughout the day (at least 2 or 3 divided doses). Taking things with food might help, although that also may (or may not) affect bioavailability.

[karoshi]

Because of my bad English, I don't know whether digestive issues mean diarrhea.
If so, stop or reduce taking cAMP rising supplements is the best way to stop diarrhea.
The rise of cAMP causes it. Cholera also causes it by the much rise of cAMP.

The other possible solution is taking Loperamide. It might help you. Its mechanism is anticholinergic, though.

[Galantamine]

You state you took something that contained it, so how do you know it was the forskolin?

I have taken forskolin and never have digestive issues, biggest issue I have with forskolin is lower blood sugar and too much vasodilation, though I still try to use it regularly.

One way to tell if you have legitimate forskolin is if it causes GI issues - specifically osmotic diarrhea. If it doesn't, then you have bunk forskolin.

Forskolin causes diarrhea by the same mechanism as cholera - by dumping chloride into the intestinal lumen via intracellular cAMP.

As someone else mentioned in this thread, loperamide is one way to combat this effect, although it has its own side effects.

[Guardian4981]

You state you took something that contained it, so how do you know it was the forskolin?

I have taken forskolin and never have digestive issues, biggest issue I have with forskolin is lower blood sugar and too much vasodilation, though I still try to use it regularly.

One way to tell if you have legitimate forskolin is if it causes GI issues - specifically osmotic diarrhea. If it doesn't, then you have bunk forskolin.

Forskolin causes diarrhea by the same mechanism as cholera - by dumping chloride into the intestinal lumen via intracellular cAMP.

As someone else mentioned in this thread, loperamide is one way to combat this effect, although it has its own side effects.

I disagree with you, I took some forskolin and had no diarrhea or GI issues. I know it was legit because my libido shot up and my blood pressure dropped.

[Galantamine]

I disagree with you, I took some forskolin and had no diarrhea or GI issues. I know it was legit because my libido shot up and my blood pressure dropped.

Your supplement may have been contaminated with something else, but without GI issues, you weren't getting much forskolin.

I would advise buying a legitimate forskolin source (i.e. Sabinsa Forslean) and seeing if you have any GI effects. Maybe you just have a baseline hypokinetic bowel?

[Guardian4981]

I disagree with you, I took some forskolin and had no diarrhea or GI issues. I know it was legit because my libido shot up and my blood pressure dropped.

Your supplement may have been contaminated with something else, but without GI issues, you weren't getting much forskolin.

I would advise buying a legitimate forskolin source (i.e. Sabinsa Forslean) and seeing if you have any GI effects. Maybe you just have a baseline hypokinetic bowel?

Well I have issues I deal with but one I never have is GI issues. Even when I used to drink a liter a vodka a night I never threw up or had issues so maybe I just have good GI genetics.

[karoshi]

You seem to have good ALD, ALDH and GI gene, but I think GI problems by alcohol is not related to GI problems by cAMP rise.
If you increase Forskolin dose, you get diarrhea or at least get loose.


Get back to the subject. If you are using PDE4 inhibitor for CiLTEP stack, try lower dose too.

[blood]

One way to tell if you have legitimate forskolin is if it causes GI issues - specifically osmotic diarrhea. If it doesn't, then you have bunk forskolin.

Forskolin causes diarrhea by the same mechanism as cholera - by dumping chloride into the intestinal lumen via intracellular cAMP.

Are there any serious, negative health consequences, if this is continued over an extended period?

[Galantamine]

One way to tell if you have legitimate forskolin is if it causes GI issues - specifically osmotic diarrhea. If it doesn't, then you have bunk forskolin.

Forskolin causes diarrhea by the same mechanism as cholera - by dumping chloride into the intestinal lumen via intracellular cAMP.

Are there any serious, negative health consequences, if this is continued over an extended period?

The only possible negative effect would be dehydration, although this would be hard to accomplish unless you literally took forskolin all day long (cholera causes constitutive cAMP activation, whereas forskolin-induced diarrhea is a function of its physical presence in the GI).

[blood]

One way to tell if you have legitimate forskolin is if it causes GI issues - specifically osmotic diarrhea. If it doesn't, then you have bunk forskolin.

Forskolin causes diarrhea by the same mechanism as cholera - by dumping chloride into the intestinal lumen via intracellular cAMP.

Are there any serious, negative health consequences, if this is continued over an extended period?

The only possible negative effect would be dehydration, although this would be hard to accomplish unless you literally took forskolin all day long (cholera causes constitutive cAMP activation, whereas forskolin-induced diarrhea is a function of its physical presence in the GI).

Does the effect (dumping of chloride) manifest in the small intestine where many nutrients are being absorbed?

Would the increased speed of passage of gut contents impair absorption of other nutrients & supplements?

[Galantamine]

Does the effect (dumping of chloride) manifest in the small intestine where many nutrients are being absorbed?

Would the increased speed of passage of gut contents impair absorption of other nutrients & supplements?

Malabsorption will probably be occuring for the time of GI-transit, which is probably how it lowers cholesterol (diminished bile acid re-absorption) and helps weight loss.

[JohnnyP]

I appreciate all the information, is there a more natural alternative than loperamide?

[xsiv1]

I appreciate all the information, is there a more natural alternative than loperamide?

http://health.howstu...or-diarrhea.htm

[JohnnyP]

Thanks for the link, I just didn't think that it was something as simple as common diarrhea. Guess its something I'm going to have to experiement with through diet.

[zorba990]

Sodium butyrate.
http://clincancerres...11/15/5651.full
You an get it here
http://www.needs.com...100/b_TE_Neesby

[JohnnyP]

Thank you very much for the links, the first one is for an article on Resveratrol? But either way thanks I wonder why SB isn't more common.

[zorba990]

Thank you very much for the links, the first one is for an article on Resveratrol? But either way thanks I wonder why SB isn't more common.

You are welcome! Forskolin and resveratrol can both cause diarrhea by the same mechanism (which is suppressed by butyrate).

[JohnnyP]

Interesting because resveratrol doesn't have this effect of me, but I have only recently incorporated it and haven't tried forskolin for a few years now so maybe I'll have better luck. I feel like I've learned so much lol.

[blood]

Sodium butyrate.
http://clincancerres...11/15/5651.full
You an get it here
http://www.needs.com...100/b_TE_Neesby

I wonder if arabinogalactan powder would work. Apparently consumption of arabinogalactan (or other soluble fibers like pectin) increases butyric acid in the large intestine via fermentation. The powder is tasteless and can be disolved in juice etc.

Edited by blood, 02 July 2013 - 06:15 PM.

[Tumah]

The 95% Forskolin is supposed to prevent GI issues as the problem seems to be come from other compounds in the plant.

[xsiv1]

The 95% Forskolin is supposed to prevent GI issues as the problem seems to be come from other compounds in the plant.

Do you have a link to a capsuled variant by any chance?

Also, what doses are we talking about here? I've purchased from planetary herbs and I think source naturals with no ill effects between 5-20mgs per day but was used as part of CILTEP. It's my understanding that those using it for body recomp are dealing with significantly higher dosages.

[Tumah]

The only one I know of is c-bolic from Better Body Sports. It's 25mg per cap. I'm actually waiting on my order but I'm planning on opening the caps to take the equivalent of 5g forskolin. I believe there is a filler, so it will require some alternate amount.