6 replies to this topic

[chung_pao]

(Copy-pasted from the CILTEP thread. Thought someone might find it exciting.)

CILTEP also potentiates Melanogenesis: The process by which skin darkens, due to melanin production, in response to UV-radiation.
I can say, after testing this assumption in the tanning bed, that it's very effective!

http://www.ncbi.nlm....pubmed/20952536

"Inhibition of PDE4 potentiates forskolin-induced CREB phosphorylation in primary human melanocytes."
"We report the identification of phosphodiesterase 4D3 as a direct target of the MSH/cAMP/MITF pathway."
"PDE4 inhibition synergizes with forskolin to induce sunless tanning in redhead/fair-skinned mice."

Rat picture: (!)
http://postimg.org/image/sjaj49ivn/

http://cancerres.aac...8/1/47.full.pdf

"Activation of the Cyclic AMP Pathway by a-Melanotropin Mediates the Response of Human Melanocytes to Ultraviolet B Radiation"
"Irradiation of human keratinocytes or melanocytes with ultraviolet (UV) rays stimulates the synthesis and releaseof a-melanotropin (a- MSH) and adrenocorticotropic hormone (ACTh), which Induce cyclic AMP (cAMP) formation and increase the proliferation and melanogenesis of human melanocytes. We report that stimulation of cAMP formation is obligatory for the melanogenic response of cultured normal human mela nocytes to UVB radiation. "

The pathway is:
UV-radiation -> alpha-MSH & ACTH synthesis and release -> Adenylyl Cyclase production -> cAMP formation (and subsequent breakdown by PDE 4D3) -> CREB- and MITF pathway (Melanogenesis)

I'm probably mistaken on some of the theoretical specifics, but the practical application is very obvious: Forskolin and/or Zembrin/Artichoke (PDE-4 inhibition) accelerates tanning.
For those not really understanding the application of CILTEP in LTP, let this be a very accurate analogy.

Now, are there any performance enhancing aspects of accelerated tanning?
For someone like me, with bad skin (Keratosis pilaris, which is alleviated by Retinol + Frequent tanning), the effects are very welcome.

Edit:
In looking for benefits of melanogenesis, I found some hilarious claims on: http://unlockthecode...ous-system.html

* Black Melanin can convert light energy to sound energy and back again!

* Melanin is BLACK because its chemical structure allows no energy to escape. It is also Black because Black is the perfect absorber of light and all energy frequencies, making Black Melanin the super absorber of Energy and Light! Thus scientists describe it as acting like a "black hole."

* Melanin is like a battery. Melanin "may be viewed as a battery that is partially charged and can always accept an electrical charge!"

* Melanin can absorb a great amount of energy and yet not produce a tremendous amount of heat when it absorbs this energy, because it can transform harmful energy into useful energy."

Edited by chung_pao, 24 June 2013 - 07:35 PM.

[YOLF]

So you can get tan without going into the sun or sitting in a cancer bed?

[chung_pao]

For the sake of experimentation I've decided to apply Artichoke+Forskolin topically the next few days.
I'll apply it to one of my feet, and monitor the potential relative changes.

If it can't be applied topically with a melanogenetic effect, I still believe very strongly that it can potentiate and facilitate the melanogenesis triggered with UV radiation (sun or tanning bed).
If anyone decides to use a tanning bed to try this, make sure to use the MINIMAL effective dose.
With CILTEP, I get tremendous results from just 3-5 minutes of exposure (tanning bed), combined with a high protein intake. (melanogenesis requires protein/tyrosine to progress)

To clarify further: I don't really propose anyone use tanning ("cancer") beds regularly. I'm doing this for the fun of finding out, and exploring biochemistry.

Edited by chung_pao, 24 June 2013 - 10:01 PM.

[chung_pao]

Experiment concluded: CILTEP doesn't stimulate sunless tanning when applied topically.
But, it definitely speeds up melanogenesis if taken orally prior to sun-exposure.

After reading up on the carcinogenic processes behind common melanomas, I won't be using tanning beds or even pursuing melanogenesis though.

[YOLF]

How would we know that melanogenesis in itself is carcinogenic? I was under the assumption that it was caused by certain wavelengths of solar emission rather than the production of melanin... Otherwise black people would be dropping like flies! I'm not aware of people of African decent having higher incidents of skin cancer, in fact, I thought it was lower. Just look at this study from the CDC (centers for diseas control... a US government organization)
http://www.cdc.gov/c...istics/race.htm

[zorba990]

Probably more work needs to be done to determine if upregulating melanin production helps or hinders longevity,
especially since we cannot necessarily rely on studies with furry animals.
More moles is associated with longevity but increased cancer risk
http://www.bbc.co.uk...health-11813378
Melanotan users report mole increases in size and darkness
http://en.wikipedia....ki/Melanotan_II
Maybe concurrent c60oo use would be preventative.

[YOLF]

Moles generally don't turn into cancer for a long long time and might infer that a particular gene associated with stopping the growth and migration of a mole might be active in other parts of the body and prevent cancer within some limit or another.

I had read that a C60 user taking low? dose methylene blue had developed freckles. I don't think I've seen any reports of freckles without the MB though. I'd be afraid to take MB myself. But he is a hero who experiments and contributes data.