14 replies to this topic

[MercuryAX]

Hi all,

In an attempt to correct my dopamine levels and enhance my learning ability, I will be employing the use of CILTEP and the Uridine combination.

From what I understand, CILTEP would increase my sensitivity to certain neurotransmitters, while uridine would help increase dopamine receptor densities. Could anyone vouch for this idea? I'm also wondering about potential safety hazards - since both should significantly affect dopamine levels.

Let me know what you think, hopefully some people will try this as well.

[EDIT] I'm also taking 200mg of SAM-e in the morning, but I'm no longer noticing any effects from it.

Edited by MercuryAX, 07 October 2013 - 06:55 PM.

[Godof Smallthings]

Abelard Lindsay recently posted that he experienced low serotonin syndrome when he tried daily uridine supplementation on top of CILTeP.

Another poster theorized that if he only took uridine 3 times per week, he might be able to prevent those effects from occurring.

I am just a happy googler with no proper science background, so take this with large buckets of salt, but maybe somebody who knows better can comment what I found:

Pantethine (results from rat study) and creatine (result from tissue cultivation study) may be able to protect dopaminergic neurons.

[abelard lindsay]

If I tried this again I would try supplementing with tryptophan or maybe doing CILTEP with Zembrin to counteract the low serotonin aspect. I'm not making any guarantees here. I'd definitely want to do it when I could have a few days to recover from feeling crappy thanks to low serotonin in case I had problems again.

[Babychris]

No offense but won't you think that you could feel better without any supps or with minimal artificial chemical crutches ? I'm particularly talking to young people under 30. I think that most of us don't need to play arround mental chemestry..

As far as I'm concerned 1mg of forksolin and 500mg of artichoke let me 2 two days overstimulated and trust me that was not placebo: when I'm overstimulated I can't even speak, I'm the prisoner of my own brain that's hard to describe. Anyway I'm not a reference since I'm so sensitive to everything, more noticeably from the time I use to take modafanil. So we can say that's just my opinion. I have much respect for the uridine stack though. I'm pretty sure that ciltep could feel GREAT for someone "normal" sense of sensitivity.

[MercuryAX]

No offense but won't you think that you could feel better without any supps or with minimal artificial chemical crutches ? I'm particularly talking to young people under 30. I think that most of us don't need to play arround mental chemestry..

As far as I'm concerned 1mg of forksolin and 500mg of artichoke let me 2 two days overstimulated and trust me that was not placebo: when I'm overstimulated I can't even speak, I'm the prisoner of my own brain that's hard to describe. Anyway I'm not a reference since I'm so sensitive to everything, more noticeably from the time I use to take modafanil. So we can say that's just my opinion. I have much respect for the uridine stack though. I'm pretty sure that ciltep could feel GREAT for someone "normal" sense of sensitivity.

No offense, but why are you even posting in this section if you believe we shouldn't have "chemical crutches"? That said, thanks for the input regarding your experience. Hopefully not many others will have this happen, including myself.

[abelard lindsay]

I speculated on another thread that *maybe* me not taking enough fish oil was the cause of my CILTEP/Uridine negative experience.

http://www.longecity...post__p__617701

[MercuryAX]

I'm currently taking uridine once every other day, instead of twice every day. I made this change after I started taking CILTEP. What I noticed is that the first day I took CILTEP, I pretty much felt like God. I had a dramatic increase in learning speed, memorization ability, sociability, and physical strength. There was once part of the day where I got hypomanic to the extent that I was fearful; I texted my friend "I don't want to be God anymore". Overall it was an amazing day. Later that night, these effects wore off and were replaced by a sort of "black hole of despair". I had anxiety and depression all of the next day, until I took an hour nap which made life bearable again. I suspect that I may have had low levels of serotonin, and that the nap helped to alleviate this.

The next two days (including today), I felt okay. I didn't really notice anything, other than that I seem to require more sleep than usual. I usually can get by on 7 or 8 hours, but I needed a coffee today despite being on 8-9 hours. I did however, have lessened anxiety and better sociability that I had on the first day. I'm taking the weekend off, getting extra sleep, and seeing how well the CILTEP works on monday. Anyone have any suspicion as to why I'd have the hypomanic reaction the first time, and then possible serotonin drain, then not much to be noticed?

Some background: I'm male, 6'1", 170lbs (lean build) with a diet mainly consisting of salad, chicken, spinach, rices, and the occasional "junk American food". I never have any dairy though, since it causes overwhelming sleepiness for me. Current supplements: CILTEP in the morning, SAM-e 200mg (last couple months), uridine monophosphate, Magnesium L-Threonate, and 4x Calamari oil (500mg DHA/130mg EPA) per day.

Only other thing is, I took 150mg of phenylpiracetam the day before starting CILTEP, and racetams do weird things to me sometimes. First time I tried phenyl, I had a similar Godlike sensation that lasted all of 20 minutes, whereas first time with CILTEP it was about 8 hours of feeling amazing.

Edited by MercuryAX, 26 October 2013 - 01:08 AM.

[riloal]

MercuryAX, any update on your combo? Thanks

[MercuryAX]

Still the same deal. I notice perhaps a subtle increase in mood but not anything as good as my second day on it. For a full report on my first week, see this: http://corpina.org/a...p-stack-review/

I'm going to try adding quercetin onto the stack and see if that helps bring the magic back.

Input from Abelard would be much appreciated. I don't get why it'd work well this one day, and not others.

[abelard lindsay]

Still the same deal. I notice perhaps a subtle increase in mood but not anything as good as my second day on it. For a full report on my first week, see this: http://corpina.org/a...p-stack-review/

I'm going to try adding quercetin onto the stack and see if that helps bring the magic back.

Input from Abelard would be much appreciated. I don't get why it'd work well this one day, and not others.

I think you taking the stack with uridine really colored your view of the stack. IMHO, that combination is experimental and not well understood. I haven't taken it long term though it's pretty great in the short term. If I was going to experiment with uridine in combination with the stack again, which I may do on a weekend, or some other time when I can afford to be out of it for a little bit I would take L-Tryptophan at night to help replenish my serotonin.

Also, do not add Quercetin!! It's too strong and not in a good way!! It was pretty much dumped from the stack midway through the thread. I would add Zembrin if I was looking for something else to experiment with.

Edited by abelard lindsay, 31 October 2013 - 04:17 PM.

[MercuryAX]

Still the same deal. I notice perhaps a subtle increase in mood but not anything as good as my second day on it. For a full report on my first week, see this: http://corpina.org/a...p-stack-review/

I'm going to try adding quercetin onto the stack and see if that helps bring the magic back.

Input from Abelard would be much appreciated. I don't get why it'd work well this one day, and not others.

I think you taking the stack with uridine really colored your view of the stack. IMHO, that combination is experimental and not well understood. I haven't taken it long term though it's pretty great in the short term. If I was going to experiment with uridine in combination with the stack again, which I may do on a weekend, or some other time when I can afford to be out of it for a little bit I would take L-Tryptophan at night to help replenish my serotonin.

Also, do not add Quercetin!! It's too strong and not in a good way!! It was pretty much dumped from the stack midway through the thread. I would add Zembrin if I was looking for something else to experiment with.

Yeah, I dropped the uridine near the beginning of the week. I was considering adding it back in, but your post makes me think otherwise.

Would perhaps a small dose of quercetin be advisable? I'm really just frustrated that it's not working anymore. Don't notice any of the motivation/learning increase. Maybe less anxiety? Also, I'm thinking perhaps I kept some benefits, but without the energy rush I had before. The other day in the gym, I WAS able to get a lot more reps in, so that's something.

Currently taking 3 capsules of NaturalStacks CILTEP. Perhaps more or less of a dose would help?

Edited by MercuryAX, 31 October 2013 - 04:27 PM.

[abelard lindsay]

Still the same deal. I notice perhaps a subtle increase in mood but not anything as good as my second day on it. For a full report on my first week, see this: http://corpina.org/a...p-stack-review/

I'm going to try adding quercetin onto the stack and see if that helps bring the magic back.

Input from Abelard would be much appreciated. I don't get why it'd work well this one day, and not others.

I think you taking the stack with uridine really colored your view of the stack. IMHO, that combination is experimental and not well understood. I haven't taken it long term though it's pretty great in the short term. If I was going to experiment with uridine in combination with the stack again, which I may do on a weekend, or some other time when I can afford to be out of it for a little bit I would take L-Tryptophan at night to help replenish my serotonin.

Also, do not add Quercetin!! It's too strong and not in a good way!! It was pretty much dumped from the stack midway through the thread. I would add Zembrin if I was looking for something else to experiment with.

Yeah, I dropped the uridine near the beginning of the week. I was considering adding it back in, but your post makes me think otherwise.

Would perhaps a small dose of quercetin be advisable? I'm really just frustrated that it's not working anymore. Don't notice any of the motivation/learning increase. Maybe less anxiety? Also, I'm thinking perhaps I kept some benefits, but without the energy rush I had before. The other day in the gym, I WAS able to get a lot more reps in, so that's something.

Currently taking 3 capsules of NaturalStacks CILTEP. Perhaps more or less of a dose would help?

Have you tried stacking a racetam? Phenylpiracetam + CILTEP is pretty awesome. I take Piracetam daily and the two interact well, especially since Piracetam is acting as a allosteric modulator of nmda and ampa receptors interacting with the synaptic cleft while CILTEP is working at an intracellular level.

[abelard lindsay]

Posted a clue to the puzzle over here:

http://www.longecity...160#entry620896

[MercuryAX]

Still the same deal. I notice perhaps a subtle increase in mood but not anything as good as my second day on it. For a full report on my first week, see this: http://corpina.org/a...p-stack-review/

I'm going to try adding quercetin onto the stack and see if that helps bring the magic back.

Input from Abelard would be much appreciated. I don't get why it'd work well this one day, and not others.

I think you taking the stack with uridine really colored your view of the stack. IMHO, that combination is experimental and not well understood. I haven't taken it long term though it's pretty great in the short term. If I was going to experiment with uridine in combination with the stack again, which I may do on a weekend, or some other time when I can afford to be out of it for a little bit I would take L-Tryptophan at night to help replenish my serotonin.

Also, do not add Quercetin!! It's too strong and not in a good way!! It was pretty much dumped from the stack midway through the thread. I would add Zembrin if I was looking for something else to experiment with.

Yeah, I dropped the uridine near the beginning of the week. I was considering adding it back in, but your post makes me think otherwise.

Would perhaps a small dose of quercetin be advisable? I'm really just frustrated that it's not working anymore. Don't notice any of the motivation/learning increase. Maybe less anxiety? Also, I'm thinking perhaps I kept some benefits, but without the energy rush I had before. The other day in the gym, I WAS able to get a lot more reps in, so that's something.

Currently taking 3 capsules of NaturalStacks CILTEP. Perhaps more or less of a dose would help?

Have you tried stacking a racetam? Phenylpiracetam + CILTEP is pretty awesome. I take Piracetam daily and the two interact well, especially since Piracetam is acting as a allosteric modulator of nmda and ampa receptors interacting with the synaptic cleft while CILTEP is working at an intracellular level.

Unfortunately, racetams don't really stick well with me. The exception is pramiracetam, which makes me very calm, focused, and basically an information sponge. It works if I take it once every week or so. Piracetam combined with even a little choline makes me incredibly drowsy, and without choline does nothing. Phenylpiracetam works at random times, and it makes me incredibly impulsive, energetic, and "manly". Another strange thing is, I am one of those people that anticholinergic medicines affect adversely - i.e. I get hyper instead of sedated.

This makes me think that my difficulties using nootropics relate to choline. However, I also heard that racetams are highly steroid hormone dependent, so that could relate somehow as well. I don't think I have any hormone issues, though.

I respond best to pramiracetam, modafinil, coffee (= caffeine and weak MAOIs) and pretty much anything dopaminergic in nature. Also I'm taking a break from CILTEP for now, perhaps to replenish calcium levels and give it another go once I understand my body a bit better.

Abelard, do you use choline regularly with your racetams?

Edited by MercuryAX, 02 November 2013 - 04:19 AM.

[abelard lindsay]

Abelard, do you use choline regularly with your racetams?

I use ALCAR which increases acetylcholine levels. Did you ever try L-Tryptophan to counteract your negative CILTEP/Uridine experience? You can also eat a few hard boiled eggs.

Edited by abelard lindsay, 03 November 2013 - 02:45 AM.