5 replies to this topic

[mait]

I stumbled across this product from Russia: a fullerene derivative (sodium salt of fullerenepolyhydropolyaminocaproic acid) seems to have clinically significant effect against HIV virus both in vivo and in vitro. There is no evidence that C60 in EVOO has same effect but never the less there may be at least a remote possibility that this may one possible mechanism how c60-EVOO has those anecdotal pro-health effects described in this forum. One of the effects I see with 25mg of C60 EVOO per week is that herpes around my mouth that usually manifested itself quite strongly when I got ill during cold months of the year has ceased to break out. Again an anecdote but this made me to search c60 + herpes and by doing it I stumbled across this Fullevir product.

From

The antiretroviral properties of Fullevir (sodium salt of fullerenepolyhydropolyaminocaproic acid) manufactured by IntelFarm Co.) were studied in the human cell culture infected with human immunodeficiency virus (HIV). The agent was ascertained to be able to protect the cell from the cytopathic action of HIV. The 90% effective concentration (EF90) was 5 microg/ml. The 50% average toxic concentration was 400 microg/ml. Testing of different (preventive and therapeutic) Fullevir dosage regimens has shown that the drug is effective when used both an hour before and an hour after infection and when administered simultaneously with cell infection. The longer contact time for the agent with the cells increased the degree of antiviral defense. Co-administration of Fullevir and the HIV reverse transcriptase inhibitor Retrovir (azidothymidine) showed a synergistic antiretroviral effect. Thus, Fullevir may be regarded as a new promising antiretroviral drug for the treatment of HIV infection.

From

The antiherpetic properties of a fullerene derivative with aminocaproic acid (manufactured by Intelfarm Co. as Fullevir) were studied in in vitro (in sensitive cell cultures) and in vivo (on a murine model of experimental herpetic encephalitis) experiments. Fullevir was found to protect tissue culture cells from the cytodestructive action of herpes simplex virus type 1. It was estimated that ED50 = 5.3 microg/ml and ED90 = 29.1 microg/ml. The agent was most effective when it was administered before and 30 minutes after cell culture infection. The in vivo study established that Fullevir showed a significant protective effect in experimental herpetic encephalitis. The protection rates were 29.8% and 41.0% with the total doses of Fullevir of 500 mg/kg (p < 0.007) and 1000 mg/kg (p < 0.004), respectively. Thus, the in vitro and in vivo studies demonstrated the antiherpetic effect of a fullerene-aminocaproic acid complex (1-hydrofullereneaminocaproic acid, sodium salt) having the trade name Fullevir.

Manufacturer web-site

[hav]

Not sure that the method of action of Fullevir would be the same as c60 in olive oil. The patent for Fullevir describes it as a water soluble fulllerene. The antiviral effect of water-soluble fullerenes has been described:

Water-soluble fullerene derivatives for drug discovery

Incorporation of water-soluble groups into the fullerene core enables investigation of its biological activities. Certain fullerene derivatives show inhibitory activity against human immunodeficiency virus reverse transcriptase. Hepatitis C virus RNA polymerase is also inhibited by fullerene derivatives. Therefore, fullerene derivatives are candidate antiviral agents. In addition, fullerene derivatives exhibit antiproliferative activity by inducing apoptosis related to the generation of reactive oxygen species.

Which is also referenced in the Fullevir patent:

... the ability of fullerenes to generate in high quantum yield singlet oxygen, which splits DNAs. These properties endow functional fullerene derivatives with cytotoxic, antiviral, and other properties (see ... US Patent 6204391, 2005, "Water soluble fullerenes with antiviral activity"

All of which sounds allot like a pro-oxidant. Whereas c60/oo seems to be more stable and function as an anti-oxidant.

But I've heard it theorized that maybe some of the c60/oo, or perhaps some undissolved or clumped c60, might form into something water soluble within the body. Maybe an antiviral effect of c60/oo might be evidence of that. Assuming it could reach a sufficient concentration. The in vitro data in the patent mentions 6 mcg/ml as a minimum with 6% to 18% effectiveness against influenza while one of the abstracts above claims 5 mcg/ml to be 90% effective against HIV.

Howard

Edited by hav, 12 October 2013 - 05:38 PM.

[mait]

Not sure that the method of action of Fullevir would be the same as c60 in olive oil. The patent for Fullevir describes it as a water soluble fulllerene. The antiviral effect of water-soluble fullerenes has been described:

Water-soluble fullerene derivatives for drug discovery

Incorporation of water-soluble groups into the fullerene core enables investigation of its biological activities. Certain fullerene derivatives show inhibitory activity against human immunodeficiency virus reverse transcriptase. Hepatitis C virus RNA polymerase is also inhibited by fullerene derivatives. Therefore, fullerene derivatives are candidate antiviral agents. In addition, fullerene derivatives exhibit antiproliferative activity by inducing apoptosis related to the generation of reactive oxygen species.

Which is also referenced in the Fullevir patent:

... the ability of fullerenes to generate in high quantum yield singlet oxygen, which splits DNAs. These properties endow functional fullerene derivatives with cytotoxic, antiviral, and other properties (see ... US Patent 6204391, 2005, "Water soluble fullerenes with antiviral activity"

All of which sounds allot like a pro-oxidant. Whereas c60/oo seems to be more stable and function as an anti-oxidant.

But I've heard it theorized that maybe some of the c60/oo, or perhaps some undissolved or clumped c60, might form into something water soluble within the body. Maybe an antiviral effect of c60/oo might be evidence of that. Assuming it could reach a sufficient concentration. The in vitro data in the patent mentions 6 mcg/ml as a minimum with 6% to 18% effectiveness against influenza while one of the abstracts above claims 5 mcg/ml to be 90% effective against HIV.

Howard

But if I remember then correctly then GVA the scientist user from Ukraine argued for that during the dissolving of C60 in EVOO some miniscule amount of hydrated fullerenes are also formed. So hypo-theoretically this is the way C60 EVOO can have some antiviral effect.

Edited by mait, 13 October 2013 - 08:48 AM.

[niner]

The fullevir effective doses are enormous, at 500 to 1000mg/kg in the in vivo experiment. Thus I'd have to say it's not much of an antiviral. There have been a number of anecdotal observations of a preventive effect against respiratory viral infections with c60-oo, and GVA says they see it with HyFn as well. He thinks this is due to improved barrier function, and I agree with that hypothesis. C60 compounds have been shown to suppress the allergic response by an effect on mast cells, and they may also be reducing the oxidative collateral damage from respiratory burst that immune cells employ against pathogens. Either of these would result in less inflammation of mucosal tissue, leading to improved barrier function. The anti-herpetic effect that mait has noticed might actually be something along these lines. While c60 may or may not have a direct effect on the virus, it might be affecting whatever mechanism triggers the viral breakout.

[free10]

The fullevir effective doses are enormous, at 500 to 1000mg/kg in the in vivo experiment. Thus I'd have to say it's not much of an antiviral. There have been a number of anecdotal observations of a preventive effect against respiratory viral infections with c60-oo, and GVA says they see it with HyFn as well. He thinks this is due to improved barrier function, and I agree with that hypothesis. C60 compounds have been shown to suppress the allergic response by an effect on mast cells, and they may also be reducing the oxidative collateral damage from respiratory burst that immune cells employ against pathogens. Either of these would result in less inflammation of mucosal tissue, leading to improved barrier function. The anti-herpetic effect that mait has noticed might actually be something along these lines. While c60 may or may not have a direct effect on the virus, it might be affecting whatever mechanism triggers the viral breakout.

OK I may have a new c60 OO story. Today I woke up drug out and had a slight flu ache and checked my temp and it was almost 100. I take C60 every so many days usually at a 1/2 teaspoon of less and decided to take a half teaspoon, to see if it helped me get through this flu. I decided about 2:30 to lie down and get some sleep and rest and after 2 or 3 hours of not sleeping got up and notice my energy seemed to be returning and no ache. I checked my temp and it was a little sub normal. Very very weird LOL

[free10]

8 hours later my temp is back to about 99.5 from 98, but no flu ache. It seems the flu is having trouble doing its thing I would guess, by the low fever temps. If the temps come up or I start feeling bad I will try another C60 dose and see if the drop happens again.