Thank you niner, impressive results. What is your dosage per week/month btw? Have people noticed a clear dose-response effect?
And I think it's easy to underestimate the placebo effect.
Absolutely! Go and read the 500mg per day resveratrol thread - which ones of the reported positive effects were actual clinical effects of resveratrol?
I take about thirty mg, once a month.
I find the comparison between c60 and resveratrol to be fascinating. The resveratrol craze started on the basis of some yeast results and a "story" of mythological proportion. We waited years for placebo controlled studies in mammals before concluding that while it was an interesting and useful substance, it wasn't likely to significantly extend life in healthy people.
With C60, there was no "story". The first thing we saw was the placebo controlled study in mammals showing dramatic life extension. Most people with experience in the field simply chose not to believe it. If they had bothered to look into the literature on C60 before making their judgement, they might have thought better of it, since Baati was far from the first paper showing unusual biological activity from c60.
The early resveratrol experiences were not entirely placebo effects. They were dominated by the stimulant effects of the other compounds present in the 50% extracts that most people were using. Those of us who used high purity extracts noted anti-inflammatory and other effects, if anything. A careful trial in athletes found some degree of improved endurance, but ultimately none of the effects were particularly earth-shaking. Before too long, reports of tendon problems surfaced. While they were mostly handled by cessation of the drug, some people had long term problems.
In the case of c60, we had pure high quality products from the start, and there were some reports of "throw away the crutches" experiences- three in particular were notable: A case of COPD in a heavy smoker, another with a mitochodrial statin injury, and a third with severe asthma. In all three cases, these were people who couldn't walk a few hundred yards without difficulty, suddenly able to walk or even run with ease. My own case of eczema that I had battled for a decade using topical steroids and other approaches felt like a miracle to me when it lifted. My doctor said "I thought you were going to have that for the rest of your life". Careful athletic testing showed huge changes for the better in trained athletes. It was frankly obvious that this was a compound with profound effect, providing you had suitable health deficits or were athletically trained. To date, the worst negative effect of c60 has been people injuring themselves in the gym from lifting too much because they could blow past their old rep limits. A couple early reports of "kidney pain" turned out to be nothing.
Resveratrol has horrible pharmacokinetics. It is absorbed reasonably well, but is rapidly destroyed by glucuronidation and sulfation. C60 has phenomenal PK. It is absorbed extremely well, since it starts out as a triglyceride, which to the body looks like food. After being hydrolyzed by lipases, the c60-fatty acid adduct is the right size, shape and polarity to become part of a membrane. All the data is consistent with the c60 fatty acid lingering in membranes for a long time, with a half life measured in days or weeks. While resveratrol must be dosed daily at a minimum, c60-oo can be dosed monthly. I've not plumbed the upper limits of c60oo PK, but if you took a very large dose(like Baati's rats), you could probably stretch it out to a year or more.
Finally, compare the media response to resveratrol with their treatment of c60. There were endless stories (and ads) about the "Red Wine Drug" that would miraculously extend your life. Everyone was selling it; you can buy resveratrol at Walmart. With C60, there were a small handful of articles about Baati's extraordinary results, then... Nothing. Crickets chirping. There's no hype or craze that I can detect. There are two major producers of c60-oo, and a few small ones. You can make it yourself, and many of us do. You can't get it at iherb. Certainly not Walmart. C60-oo appears to be spreading mainly by word of mouth. This forum is the only place on the web that has ever had significant or knowledgeable discussion about it.