Hello,
I got bored and typed in "NMDA" at eBay, and saw pure NMDA being sold. Tried searching for oral bioavailability info, but no luck.
Is it orally active?
Cheers.
Posted 13 March 2014 - 10:29 AM
Posted 13 March 2014 - 01:52 PM
Edited by andrea23, 13 March 2014 - 01:53 PM.
Posted 13 March 2014 - 03:05 PM
Posted 13 March 2014 - 03:29 PM
NMDA is an excitotoxin (it kills nerve cells by over-exciting them); this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term "lesion studies". Researchers apply NMDA to specific regions of an (animal) subject's brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior. If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior.
D-Serine, synthesized in the brain by serine racemase from L-serine (its enantiomer), serves as both a neurotransmitter and agliotransmitter by coactivating NMDA receptors, making them able to open if they then also bind glutamate
Edited by abelard lindsay, 13 March 2014 - 03:32 PM.
Posted 13 March 2014 - 03:48 PM
Posted 13 March 2014 - 06:45 PM
Edited by formergenius, 13 March 2014 - 06:45 PM.
Posted 13 March 2014 - 07:46 PM
Posted 20 March 2014 - 05:23 PM
If your NMDA receptors are downregulated I'm afraid you're only gonna make it worse with agonists. There was a time I was consuming a lot of gelatin (glutamic acid + glycine) every day. It definitely made me feel a lot better for a while (brighter colours, connected with your surroundings, great mood, calmer etc). But after a month it stopped working and I was actually worse off after that and I still am. Now when I consume enough gelatin it only makes me feel anxious.
Posted 22 March 2014 - 02:17 PM
Posted 22 March 2014 - 08:19 PM
Yes I've taken NAC for a long time, but it never did anything. What dose of Pregnenolone do you take, and how long did it take to see benefits?NAC and pregnenolone are probably the best NMDA modulators out there. Since I believe I have some kind of genetic problem with my voltage gated calcium ion channels, I've taken both of these for quite some time. Preg is purported to cause new NMDA receptors to form on the cell, and NAC effects NMDA function via the redox cycle. I have taken sarcosine, but the combo of preg/NAC is far more potent in my experience. Try these before trying anything as risky/untested as oral NMDA.
Posted 23 March 2014 - 05:21 AM
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