LONGECITY

NRX-1074 Announcement:

We are pleased to announce that after over a year’s tireless and dedicated work, we have produced a sound method to NRX-1074, battling multiple incredibly difficult synthesis challenges.  Within this, though we are thankful to have accomplished a successful production route enabling our ability to supply this important material, we incurred highly substantial losses, as the estimated methods and yields were unworkable; thus, it was quite a bit more costly to produce than estimated.

 

Unfortunately, being that the production cost basis was well above our initial estimates, we are taking losses on the pre-orders we are set now to fulfill.  However, if enough are interested, we are willing to do a second run selling at near cost, considering we already put in all this time and effort.  Notably, obviously even at near cost it will be higher than what we offered for pre-order pricing, due to our estimates that by all accounts seemed rationally well calculated, but proved otherwise. 

 

We are still determining the final pricing, as we are trying to see if we can arrive at a slightly better cost basis, with a final slightly refined tweaking of the route.  Such pricing will be announced here shortly and as well as placed up on the site.  It will be in the same fashion as the last pre-order situation, where we need "pre-commitments" to determine we have sufficient demand to even be able to do it at all, to satisfy the need for a minimum production basis.

 

To those with outstanding pre-orders, our apologies that this production took so long; however, trust we dedicated time and effort well above and beyond, such that is not even accounted for within losses absorbed.  It turned out to be a tremendous overall undertaking, but we were determined to succeed and have done so.   Current pre-orders will start to ship shortly after the New Year and we will be in contact prior to confirm the correct current delivery address.

 

Obviously, it has been seen that other groups who attempted this flat out failed, so it is well known this is a monster of a difficult synthesis.  Moreover, no other group is doing what we are doing with this type of scope and dedication, so we hope it is appreciated and further displays our commitment to our stated goals and mission.

 

SkQ1

Note, if there is interest, we have recently achieved the ability to produce SkQ1.

We will need to see interest expressed in strong order to produce such as to the viable minimum basis.  Reference is $2000/1g run and $1500/g for a 4-5g run, as to the basis for some relative commitments.  We’d look at selling as 0.1g and up with the lower end amounts of course having a respective slightly higher price basis.

 

If within this someone feels a group buy dynamic can be supported to allow for a successful ‘mass’ of interest, please feel free to contact us to discuss such or start a separate thread perhaps.

 

New Year’s Special

Lastly, for those who have interest (and actually made it this far, lol), we are doing a New Year’s Special of 20% off select items.  So, feel free to contact us for this list if desired.

 

Thank you again for your kind support and a most Happy and Healthy New Year for all!

TeamTLR

 

Nice you succeeded what so many others failed. I would like to know if those who were willing to make a group buy are still interested.

 

Moreover, Forty Six & 2, could it be that your customers write feedbacks here about the impact on their situation ? If positive it could boost the interest.

Thanks.

 

SkQ1
Note, if there is interest, we have recently achieved the ability to produce SkQ1.
We will need to see interest expressed in strong order to produce such as to the viable minimum basis.  Reference is $2000/1g run and $1500/g for a 4-5g run, as to the basis for some relative commitments.  We’d look at selling as 0.1g and up with the lower end amounts of course having a respective slightly higher price basis.

 
Isn't the same product being sold here for orders of magnitude less?
Edited by telight, 01 January 2017 - 03:04 AM.

As to the post directly above, that is not SkQ1 [CAS# 934826-96-0], but CAS# 32339-43-8.  A far, far simpler and less costly compound to produce.

 

Certainly it would be nice if SkQ1 could be produced for anywhere remotely in that area, but such is not so.

 

The very best pricing I am aware of otherwise for SkQ1 is at ~3600USD/g basis, for reference.

Everyone, please be aware that some time ago Ceretropic did a lab analysis on many of the compounds offered by TLR, and the results indicated that most of their products were actually taurine. 

 

I've also heard down the grapevine that the owner of TLR is a very strange person. 

 

I just felt obligated to post this given that this thread was intended to produce the real compound NRX-1074, and not some bunk taurine or other such compounds from a nut job.

Redan is a well known Troll (a CereTroll, shall we say) - so not at all a surprise to see his sad act drop by here at this time. 

 

Those slanderous accusations, among others, were proven erroneous by experts right here at Longecity. (obviously Reddit/noo itself is largely controlled by Ceretropic and followers of such).  Such OLD news, such a headache when we had to deal with these sorts of corrupt people prior; so, we will make no further acknowledgement or comment to such corruption and sociopathy.

 

Obviously indeed strange folk at TLR; we actually have integrity and dedication - strange indeed in this day and age.

 

Happy New Year, though nothing changes - some look to 'build' and some look to 'destroy' - we'll keep on building, thank you~

https://www.reddit.c...esting_results/

 

https://www.reddit.c...r_package_from/

All the above and other such testing was shown clearly to be of dubious intent (total conflict of interest, of course), totally unprofessional, inaccurate, and within it all slanderous.

This was all dealt with thoroughly ages ago right here on Longecity, as obviously Reddit is corruptly controlled, which is proven as well within such.

 

But thanks for dredging back up those sorry attempts at damaging TLR. Anyway, as this has been dealt with as so noted, I have requested the moderators take appropriate action.

 

Brgds~

All the above and other such testing was shown clearly to be of dubious intent (total conflict of interest, of course), totally unprofessional, inaccurate, and within it all slanderous.

This was all dealt with thoroughly ages ago right here on Longecity, as obviously Reddit is corruptly controlled, which is proven as well within such.

 

But thanks for dredging back up those sorry attempts at damaging TLR. Anyway, as this has been dealt with as so noted, I have requested the moderators take appropriate action.

 

Brgds~

 

 

So, why don't any of your fancy products have 3'rd party COA's? You wouldn't have to deal with such accusations anymore.

I don't think reddit is the Bible, anyone (including competitors in this case) can bash someone based on proofs or tests we don't know anything about.

I'm really not impressed buy those accusations. All i have to say to Forty Six & 2 is that you could destroy those suspicions buy providing a third party lab test and then we could go on safely making orders. As the product will be pricey i think you could follow this way, the interest here for NRX is high which could result in lots of orders.

Certainly we can address this once we have established a pricing basis to announce, one that allows us to minimally be at slightly above a break even, as prior noted.

Here at this juncture we have taken well over a year to achieve what we have, with notable significant losses on this project.  We know 'in house' we have [finally] arrived at a successful synthesis of the compound and with a method that is about as financially cost effective as we feel is able to be so. Prior test productions displayed methods that seemed sound in theory to be a cost basis that was unduly exorbitant, as we tried several methods and at many junctures thought we had an excellent game plan for sound success.  So to be at this basis was an exceptionally hard fought effort. 

 

If it appears financially feasible and worthwhile to produce, within the interest at the pricing required to produce and so to be announced, we will certainly be willing to include for the cost of third party analysis.  Such is not inexpensive wherein there is no standard, as many are aware.

 

Frankly, though we would certainly like to do another production, I highly doubt the interest will be there at the necessary pricing basis and minimum quantity needed to be produced to be of any sound basis.  Notably, we were only able to even think to move forward with this first production due to two parties who engaged a very sizable amount of the compound.  Without those two it never would have even thought to be attempted.  This was as well obviously at a basis that we know we cannot once again offer. 

 

Within those who are aware, it is known there has not been one assay of a synthetic compound we have ever supplied that shows it to be other than what it should be.  Moreover, one knows that people post when they are upset with a company or with what they have received.  That we have been around now for two and a half years and this is not seen I would think says quite a lot.

 

Bearing all, we will as always look to do what is best overall, as best we can. Kindly wait for our announcement before we approach further discussion as to anything related to future productions or otherwise.  We hope to make such an announcement soon, though such things always tend to take longer than one would like, within the challenges of trying to arrive at a best means.

 

Thank you for you interest and stay tuned ;-)

OK guys, this Group Buy became a shady shit show. Let's forget about NRX-1074 if it's too difficult to synthesise and instead start talking about the much similar compound AV-101 which has similar mechanism of action but is further along in clinical trials. I started a thread about it here:

 

http://www.longecity...lorokynurenine/

 

 

 

I've still been following the developments for this compound. It seems Allergan found a simpler structure that mimics the effects with better oral bioavailability. 

 

Once the structure comes out, I'll let you guys know.

 

As per usual, I have no involvement in any group buys; but, am still interested in seeing an NMDA-Glycine partial agonist with potent antidepressive and nootropic qualities come out to the public. 

if anyone may be so interested for pursuit of research with NRX-1074 note we have stock of NRX-1074 ~99.7% purity and are affording a one-time "pro-research" sale for this at 20% off through 5/15/17 - just send an email to tlr@teamtlr.com after placing any such order.

 

Limted stock, so "while supplies" last applies, as this will be valid only for present stock.

 

Best of success with all your research pursuits!~

 

 

Hey i just received some ro-25-6981 in maleate form and I'm planning a small test dose. This threads pretty old but does anyone know if it's orally active or how it needs to be administered. And has anyone found any papers that would let me extrapolate what a starting does should be?

Did anyone end up receiving NRX-1074? Either from TLR or otherwise

I've still been following the developments for this compound. It seems Allergan found a simpler structure that mimics the effects with better oral bioavailability. 

 

Once the structure comes out, I'll let you guys know.

 

As per usual, I have no involvement in any group buys; but, am still interested in seeing an NMDA-Glycine partial agonist with potent antidepressive and nootropic qualities come out to the public. 

 

Did the structure ever come out?

Just to note, it was produced to >99% purity and distributed. 

 

https://teamtlr.com/...neurogenic.html

(current batch is >99%, though the standard within the site is noted at >98%)
 

It is presently stocked, though fairly expensive - as such we have most purchases from research and academic institutions.

We do often discount upon request, where we deem warranted for some worthwhile reason.

 

Brgds~

As per my previous post I've continued following the developments of this compound. It looks as though Allergan has found a more simple molecule as a partial agonist at NMDA receptors. 

 

What's really new is I found out that Naurex, the creators of NRX-1074 and GLYX-13, spun off another company after the acquisition from Allergan of Naurex. The new company is called Aptinyx and they've developed a new compound called NYX-2925 for the treatment of Painful Diabetic Peripheral Neuropathy and Fibromyalgia(Exploratory). I've contacted them and asked why don't they target depression or schizophrenia and they replied back to me saying that the IP to treat those disorders are wholly owned by Allergan when they acquired Naurex.

 

I've done some research in regards to the nootropic potential of NYX-2925 and the results are promising. It's highly active in rats at 0.1 mg/kg, the effects last a week, and is orally bioavailable.

 

Relevant images:

 

https://ibb.co/mx2Gdx 

 

https://ibb.co/mx2Gdx

 

(Last link didn't work in previous post)

I did some searching and found that a well known and trusted supplier of nootropics from China, known as Wuhan Hengheda Pharm Co., Ltd, is offering NRX-1074 at 1g for 800 USD.

 

I have no intent in gathering funds unless necessary to purchase this product for nootropic and depressive purposes. 

 

Please check Alibaba in case you're wondering where I got this price. I am confident they have this product and am keenly interested in participating in a group buy for it, just without the managerial role. 

 

If anyone has the interest and equipment to purchase 1g and split it into 10 vials or in an aq. solution for administration via intranasal method please come forth. 

 

Thanks.

 

This group buy will be for 10 individuals, at 80 USD for 100mg. 

 

NRX-1074 is a very potent compound so, 100mg will last a long time. Please do your own research into this promising compound for depression.

I sent a bunch of quotes for NRX-1074 through Alibaba. I'm inclined to stick with Wuhan Hengheda Pharm Co., Ltd, due to past experiences with them by other members. 

 

My hope in conducting the group buy through Alibaba Trade Assurance can be found here:

 

https://www.longecit...-buys-by-redan/

The minimum oral dose tested in clinical trials was around 375 mg. What is 100 mg going to do for anyone? Are you going to administer it IV?

The minimum oral dose tested in clinical trials was around 375 mg. What is 100 mg going to do for anyone? Are you going to administer it IV?

 

 

Wow, I didn't know that. I know there's an issue with bioavailability which I hoped to mitigate with intransal administration. 

 

If what you're saying is true then this group buy is a failure. I guess time to move onto: https://en.wikipedia...wiki/AGN-241751

 

Failed group buy then...

There's this compound that Naurex developed. I want to synthesize it. See: https://ibb.co/e0byrH

Also:

 

Very potent and long lasting:

 

https://ibb.co/e0byrH

What do you guys think about a custom synthesis of:

 

https://en.wikipedia...iki/Tulrampator

 

It has all the qualities of a nootropic like NRX-1074 and even more. 

 

I don't know about the dose in humans or bioavailability. But, a custom synthesis would be possible...

The minimum oral dose tested in clinical trials was around 375 mg. What is 100 mg going to do for anyone? Are you going to administer it IV?

 

 

What do you think about a group buy for the simple and available compound through Alibaba, GLYX-13? What would be the doses required for therapeutic effects via intranasal route?

What do you think about a group buy for the simple and available compound through Alibaba, GLYX-13? What would be the doses required for therapeutic effects via intranasal route?

 

Nyles7 had some of that I believe, the impression I got was that it was underwhelming as he was trying to offload some of it

I would be interested in buying a glycine site NMDA modulator like NRX 1074 or GLYX-13 as they sound really promising.

Doses for NRX 1074 are supposed to be around 5-10 mg iv so it should be ok intranasal for the current price

https://discord.gg/6JFmppErDs

 

Synthesis of NYX-2925 ongoing at Discord.