LONGECITY

I am not able to procure this compound at this time. I do not know when I could get this compound. Sorry guys.

You could get it from teamtlr.com 

Still needs to be checked if it is really what you want and halfway safe.

This synthesis is extraordinarily difficult.  To be straight, I knew there was no way it was going to be produced by any other parties, or would have been quite surprised to see such (and no way at said cost basis reported).  

It has been a challenge far beyond what was even already anticipated to be highly difficult, however, we are doing last purifications and should have the NRX-1074 in hand soon aliquoted in 50mg sterile vials.

Notably, we got crushed on the yield relative to what is anticipated, so we are basically not making anything at current pricing. 

This batch coming is just covering present pre-orders.  We are in process with a second batch as well, which should be ready in 3-5 weeks.

This second and final batch is as well limited, so when it is gone, it is gone.  Much of this batch is already reserved via pre-orders and it is limited as to what is still available.

Within our research with the small amount of material we pulled before final purifications, we have seen solid efficacy in animal model research.

While nothing can be construed as undeniable 100% safe, all signs point to it being a highly efficacious and safe agent.

For those who wish for an alternative that is oral administered and less costly to perform appropriate research and acts via the same pathway with similar efficacy, we as well have seen stellar results with our GLYX-OX matrix, even exceeding high expectations.

One may as well wish to combine the two agents, therein being able to use lower doses of each.  Further, a low dose os our SNRB-OX further potentiates the efficacy.

Best of Success to all who engage progressive research in this area. 

im am very interested in nrx! wouls join a group buy in a heart beat.

Guys what about glyx-13, maybe that would be easier to synthesis. I dont mind shooting it intravenously. What do you think? 

So is TLR not going to continuously stock NRX 1074?  If not then I would like to participate in a group buy.

,, The effect of a single dose of GLYX-13 was nearly twice as great as the effect seen in clinical trials of most conventional antidepressants after 4–6 weeks of treatment.'' Hope we will be able to obtain this molecule soon.

I have recently placed a post, while looking for an alleged "Ketamine cousin" from nature from a 2013 research from South Korea: 

http://www.longecity...on/#entry765325
 

Radix Polygalae

Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract. (2014 study)
http://www.ncbi.nlm....pubmed/24520403
http://journals.plos...al.pone.0088617

At least that research paper concludes on Radix Polygalae, the root from polygala tenuifolia (a.k.a. yuan zhi -> Chinese: 遠志), the following: 

 

What am I missing here? RP 10:1, 20:1 extract is fairly cheap, bought from Alibaba. Got a few quotations so far with Certificate of Analysis (most likely forged, but they eventually won't send salmonella or E-coli, or heavy metals on it) so it could allow people to try it out. 

Of course the raw extract cannot be matched to the preparation made in the articles above. What I question is what exactly did these preparation methods did to the extracts they used, in terms of added value. I know nothing about herbal extract preparation methods .. although I guess that it takes ... Something like this?: 



Any Walter White here that knows how to interpret the above studies' extract preparation methods?

and/or comments on this "herbal" approach viability? 

I'm not trying to redirect this thread to another, but here is a short discussion (at the time of this posting), that complements this one.

Please note that the intranasal dose was less than 10% of the lower standard for IV use of GLYX

Granted it's only one data point, but it'd sure be nice to get some more points on the chart

http://www.longecity...orting-glyx-13/

I just noticed that on alibaba, "Wuhan Hengheda Pharm Co., Ltd." offers NRX-1074 for sale. They have a good reputation on these forums and elsewhere of providing authentic and real products. 

Would anyone be interested in participating in a group buy from them?

I'm going to send a price quote for NRX-1074 from them and see what happens. Anyone else interested is welcome to do the same:

http://www.alibaba.c...chText=NRX-1074

Unfortunately, after talking with them they do not have either GLYX-13 or NRX-1074 at this time. 

I will pursue this matter further as to whether they can make a custom synthesis of it.

I'll order a kg of Radix Polygalae extract in the next week if you like.

I'll also find out the extraction method. I trust this source and have used them many times without issue.

 

Unfortunately, after talking with them they do not have either GLYX-13 or NRX-1074 at this time. 

 

I will pursue this matter further as to whether they can make a custom synthesis of it.

 

Could you perhaps ask them if they can produce d-deprenyl? 

I would consider organizing this group buy. What did Wuhan say, Redan?

I would consider organizing this group buy. What did Wuhan say, Redan?

That they don't have it at this time... But, they did say they were working on it. I wouldn't count on them, at least not in the near term. The synthesis requires a special and hard to obtain intermediate from what I gather. 

I have a link for that intermediate; but, it alone costs quite a bit also.

Best regards.

I would consider organizing this group buy. What did Wuhan say, Redan?

Any updates on this Nick?

Thanks.

I posed a reddit topic on the 90% reduction in learning time for rats found in 2 papers.

Just some more interesting stuff outta this amazing compound.

https://www.reddit.c...for_mice_by_90/

Is it too late to join?

The more the merrier.

Does anyone have contact information to the user who used to post here under the nick: "Googletarian"? I suppose a reputable Polish lab would be able to synthesize this given enough interest and funding, all of which should not be an issue at this point.

Cheers.

Does anyone have contact information to the user who used to post here under the nick: "Googletarian"? I suppose a reputable Polish lab would be able to synthesize this given enough interest and funding, all of which should not be an issue at this point.

 

Cheers.

Wasnt he the lad who tried to scam scienceguys groupbuy? The lab broke up and never refunded the cash?

 

Does anyone have contact information to the user who used to post here under the nick: "Googletarian"? I suppose a reputable Polish lab would be able to synthesize this given enough interest and funding, all of which should not be an issue at this point.

 

Cheers.

 

Wasnt he the lad who tried to scam scienceguys groupbuy? The lab broke up and never refunded the cash?

 

Did that actually happen? Wow...

Well, if anyone knows a lab that would be able to synthesize this, please let us know. (I'm not handling the group buy though)...

I arrived at the same conclusion as you redan. I'm not sure a polish lab is necessarily viable, though I could look into it.

I'd like to join this group buy if at all possible

I'd like to join too. It seems though like this isn't much off the ground unfortunately, but count me in when you determine the price of meting this stuff out.

TLR said that their next batch of NRX-1074 would be ready early May

I'd be very curious to hear reports. From the research it seems a comparatively large dose it required.