I am also homozygous for MTHFR C77T and tried the suggestions mentioned in this thread.
2mg sublingual MB12 overstimulate me while 1mg HB12+1mg A(denosyl)B12 made no significant difference. Both have been coupled with 400mg SAMe+ 50mg P5P+800mcg 5-MTHF and both tests have been performed on an empty stomach first thing in the morning.
It is strange because as per Yasko (see table on p.10 in the linked doc) HB12 and AB12 should be the preferred ones in my case (I am COMT V158M +/- and VDR Taq +/-).
And I have taken potassium source (as 2g potassium citrate) only when I took the HB12+AB12 dose (it is one pill) and not when I took MB12 which , if I understood correctly, should have only potentiated the effect of the B vitamins combo.
That being said, I often eat bananas and pears which should be a decent source of K.
I regularly take 0.5-1mg MB12(with 25-50mg P5P+400-800mcg 5-MTHF, often with 400mg SAMe) with the above combo as part of my daily regimen but don't feel any significant boost. 2mg MB12, however, causes this unmistakeable stimulation /pressure in my forehead (not sure if that's good or bad sign).
I can't say I feel more energized physically or mentally, though.
IIRC I tried 2x 1mgHB/1mgAB12 pills once (4mg total cobalamin) and had similar experience so MB12 seem more effective in that regard (eliciting the same response at half the dosage).
With respect to the molybdenum suggestion, I regularly eat lima beans and red split lentils which seem like a very good source of molybdenum so perhaps I don't need additional supplementation.
I tried NAC at 600mg a few times but did not "feel" any effect. Same from 500mg Setria reduced glutathione although I believe in the science behind it.
I also regularly take 15ml C60oo per week which initially resulted in boost in olfactory function but nowadays I can't say I notice a difference - maybe I reached a permanently improved state.
Energywise, I can't say I feel super improvement in terms of strength or endurance but I am not very active to begin with. Perhaps there is some benefit since on my last hiking trip I did not feel much exhaustion even though the terrain was pretty challenging and the trek rather long. I believe it is working and will continue taking it.
Thank you all for the interesting discussion.
Edited by aribadabar, 07 October 2015 - 04:16 AM.