9 replies to this topic

[Anewlife]

Ketamine, cocaine, marijuana, dianabol all effect me literally 3-5 times stronger than they should, I need only a very small dose.

Other drugs like nicotine, arimidex, pregnyl, alcohol, amphetamines are normal.

Based on my experience with cocaine (getting high off crumbs) some of friends think I'm completely insane as in would fail a placebo test. (Ie Snuffing talcum powder and going manic) I disagree.

When I did dianabol my lifts increased 3 times their weight and my liver enzymes were insane.
I'm the only person on the internet with this experience hence i feel i need to see a geneticist out of curiosity to see if I got the right chromosomes or something....

Any insight?

[Danail Bulgaria]

The human body adapts and lowers the effect of all of these "Ketamine, cocaine, marijuana, dianabol". With the time to get the same effect you will need bigger and bigger dose. Maybe you take them from soon. If you are ot addicted, better stop them until it is not too late.

[Anewlife]

I've only tried those drugs once.

I mean I need a baby dose and I get exaggerated effects. Triple strength on dbol. Crazy libido on peanuts worth of coke. I'm really confused why this is because no one else can relate. I thought I had autism but I have been cleared of that. I am also not schizophrenic. But that wouldn't explain the excess response to dbol.

[Danail Bulgaria]

Don't take them, man. They may lead you to very bad things, including completely destrying and ending earlier your life. If you are this sensitive to them, you may even overdose very easy.

[niner]

When you're sensitive to some drugs, but not others, or if you are insensitive, you probably have a mutation in one of the enzymes that metabolizes those compounds, or is involved in transport of them.   P450 3A4 is involved in the metabolism of ketamine, dianabol, and cocaine.  THC is mostly 2C9.  You could have multiple mutations; everyone does, it's just a matter of where in the genome they are.  (there are millions of locations in the genome than commonly vary, so we don't even really call them "mutations", instead using the term "Single Nucleotide Polymorphism", or SNP.   If it's really a 3A4 issue, then you may find that you are sensitive to a lot of pharmaceuticals, too.

[Anewlife]

Hmm interesting that explains it I guess.
So when you say mutation you mean it's acquired through environment such as genotoxicity?

I keep hearing about p450. Anyway do I need to see a geneticist? If so what do I say?

[niner]

No, it's usually acquired from one or both of your parents.  You couldn't really get something like this from an environmental exposure after you were born.  There's nothing you need to do.   It would be possible to use different test compounds, and see how you metabolize them, in order to pin down exactly what's going on.

[Anewlife]

My parents had me late, that's what's going on I think.

[niner]

My parents had me late, that's what's going on I think.

 

It probably wasn't that-- More like a luck of the draw affair.  It could be advantageous in some ways, like you don't need to spend as much on drugs, and you might be more resistant to certain types of carcinogenic compounds.

[Anewlife]

I am meant to have good telomeres or whatever it's called and have a longer life expectancy but I feel am an exception to that.