110 replies to this topic

[Astroid]

They generally recommend taking LDN prior to bedtime and ALA during the day.  LDN works 4 hours at 4.5 mg dosage. Some smaller people use even less. They also use it for dogs and children (with ADD especially) at lower dosages.   

 

I have noticed no mental impacts on sleep or mood myself. 

 

If one drinks alcohol, one will not get a buzz. Originally LDN was used for those with drug or alcohol addiction. However, one can drink first, then take it and both still work.  

 

I can post and send you some noted on LDN.  I don't see exactly where to post them under files or such here.   

[itpp]

Thank you so much
I'm waiting on my shipment seems like its going to take a couple weeks

[Astroid]

I'd expect it in a week.  

[itpp]

I'd expect it in a week.

Would you start 4.5mg off the bat or slowly work your way up? I'm reading people starting with 1-1.5mg and slowly build up to avoid the side effects LDN brings the first couple weeks or so.

I got the 4.5mg size on the way

[smccomas01]

Something to be aware do not mix Naltrexone with Opiod based pain meds. 

[itpp]

Something to be aware do not mix Naltrexone with Opiod based pain meds.

Thank you for the heads up

[Astroid]

One doctor said 4.5 mg was like taking "Dust".  Some maybe sensitive, or image it.. but I never saw an MD recommend starting with lower doses and building up.  Take it at night and you will sleep through the active period. 

 

I even gave my 73 lb dog 4.5 mg when she had a allergy to flea bites.  I did not notice any problem with her. 

 

If one is healthy, not fighting a serious illness like cancer.. you don't have to take it every day.. You could take it 4-5 days a week and still benefit.   

[gatornoot]

What dose are you using?

Interested since I also have RA.

Dosage recommendation seems to be 600mg twice a day, then 300mg twice a day thereafter.

[itpp]

Thank you both

[niner]

 

What dose are you using?

Interested since I also have RA.

Dosage recommendation seems to be 600mg twice a day, then 300mg twice a day thereafter.

 

We've been talking about several different substances in this thread; what are you talking about here?  I'd hate to see someone take 600 mg of Naltrexone and die of a seizure or something...

Edited by niner, 03 January 2015 - 03:35 AM.

[itpp]

What dose are you using?

Interested since I also have RA.

Dosage recommendation seems to be 600mg twice a day, then 300mg twice a day thereafter.

We've been talking about several different substances in this thread; what are you talking about here? I'd hate to see someone take 600 mg of Naltrexone and die of a seizure or something...

Lol I'm assuming that was for c60

[niner]

 

 

 

What dose are you using?

Interested since I also have RA.

Dosage recommendation seems to be 600mg twice a day, then 300mg twice a day thereafter.

We've been talking about several different substances in this thread; what are you talking about here? I'd hate to see someone take 600 mg of Naltrexone and die of a seizure or something...

Lol I'm assuming that was for c60

 

That would be about a liter of olive oil a day; nine thousand calories, if something else horrible doesn't happen first...  C60 doses people here are using are anywhere from less than a milligram a day to 50 mg/day, but around a milligram a day is common.

[itpp]

What dose are you using?

Interested since I also have RA.

Dosage recommendation seems to be 600mg twice a day, then 300mg twice a day thereafter.

We've been talking about several different substances in this thread; what are you talking about here? I'd hate to see someone take 600 mg of Naltrexone and die of a seizure or something...

Lol I'm assuming that was for c60

That would be about a liter of olive oil a day; nine thousand calories, if something else horrible doesn't happen first... C60 doses people here are using are anywhere from less than a milligram a day to 50 mg/day, but around a milligram a day is common.

Lol lol

Thank you for the heads up

[Astroid]

Low Dose Naltrexone is recommended at 4.5 mg or less per night.    

 

In addition it is suggested one take Alpha Lipoic Acid at 600 mg per day.

 

I think C60 would be great along with this.  I've been taking C60 along with the above for about 12 weeks now.  I feel so refreshed and pain free waking up I am amazed.  I noticed that the first day too.   

[itpp]

Low Dose Naltrexone is recommended at 4.5 mg or less per night.

In addition it is suggested one take Alpha Lipoic Acid at 600 mg per day.

I think C60 would be great along with this. I've been taking C60 along with the above for about 12 weeks now. I feel so refreshed and pain free waking up I am amazed. I noticed that the first day too.

With whom you purchased your c60 from

[Astroid]

www.carbon60oliveoil.com 

[Walter Derzko]

Carbon 60 Hydrated Fullerenes from Ukraine  have helped a number of arthritis sufferers

 

From PUBMED  see attached

 

 

 

Attached Files

•  FACTSHEET 2 0 The Link Between Free Radicals and Arthritis v2.pdf   341.21KB   11 downloads

[Walter Derzko]

Carbon60 in Olive OIL or C60OO is not approved for human internal use in any country as far as I know or has that changed recently?

[zen]

Carbon60 in Olive OIL or C60OO is not approved for human internal use in any country as far as I know or has that changed recently?

 

Every currently approved drug/substance was not approved at some point of time.

Toxicology studies showed that C60 is non toxic for rats in dosage as high as 1g/kg/day - "Sub-acute oral toxicity study with fullerene C60 in rats" by Mika Takahashi,... published in 2012 .
On the other hand, Baati C60 Olive oil study showed that it is not only safe but also extends lifespan of rats.

Yes, you are absolutely right, it is not approved for internal use for humans, feel free to wait for an official approval if this gives you pace of mind.

 

Edited by zen, 11 January 2015 - 06:26 PM.

[markymark]

I came across this paper in medline. People are planning to inject C60 into the joint space (see the pics, of this open sourde article :-)).

Looks like a good idea in degenerative- , as well in the auto immune "rheuma" joint diseases( Anti-CCP-positive, lupus/overlap etc.)

 

I wonder how many c60s are makeing it into the joint space or joint liquid after oral ingestion, which we do...?

 

Connect Tissue Res. 2014 Apr;55(2):71-9. doi: 10.3109/03008207.2013.877894. Epub 2014 Jan 24.

The applications of buckminsterfullerene C60 and derivatives in orthopaedic research.

Liu Q¹, Cui Q, Li XJ, Jin L.

Author information

Abstract

Abstract Buckminsterfullerene C60 and derivatives have been extensively explored in biomedical research due to their unique structure and unparalleled physicochemical properties. C60 is characterized as a "free radical sponge" with an anti-oxidant efficacy several hundred-fold higher than conventional anti-oxidants. Also, the C60 core has a strong electron-attracting ability and numerous functional compounds with widely different properties can be added to this fullerene cage. This review focused on the applications of C60 and derivatives in orthopaedic research, such as the treatment of cartilage degeneration, bone destruction, intervertebral disc degeneration (IVDD), vertebral bone marrow disorder, radiculopathy, etc., as well as their toxicity in vitro and in vivo. We suggest that C60 and derivatives, especially the C60 cores coupled with functional groups presenting new biological and pharmacological activities, are advantageous in orthopaedic research and will be promising in clinical performance for musculoskeletal disorders treatment; however, the pharmacokinetics and toxicology of these agents as local/systemic administration need to be carefully determined.

PMID: 24409811 [PubMed - indexed for MEDLINE]   PMCID: PMC4124742   Free PMC Article

 

 

Edited by markymark, 14 January 2015 - 12:06 PM.

[Walter Derzko]

MarkyMark

Both Rheumatoid and osteoarthritis is triggered by oxidative stress or excess free radicals. People drinking Carbon 60 hydrated fullerenes (0.0002mg/100ml) have seen a marked decrease in pain symptoms from arthritis after 21 days, if their baseline free radical levels are initially low. Works both with injections and after oral administration.


Rheumatoid arthritis and oxidative stress

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation of the joints and tissue around the joints with infiltration of macrophages and activated T cells (4, 25, 26). The pathogenesis of this disease is due to the generation of ROS and RNS at the site of inflammation. Oxidative damage and inflammation in various rheumatic diseases were proved by increased levels of isoprostanes and prostaglandins in serum and synovial fluid compared to controls (26).
Source: Free Radicals, Antioxidants in Disease and Health
http://www.ncbi.nlm....les/PMC3614697/

###

Free radicals in primary knee osteoarthritis.

J Med Assoc Thai. 2009 Dec;92 Suppl 6:S268-74
Sutipornpalangkul W1, Morales NP, Harnroongroj T.
Author information: Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. tewsv@mahidol.ac.th
AbstractFree radicals have an important role in the pathogenesis of knee osteoarthritis. Reactive oxygen species (ROS) produced by abnormal chondrocyte metabolism exceeds the physiological buffering capacity and results in oxidative stress. The excessive production of ROS can damage proteins, lipids, nucleic acids, and matrix components. They also serve as important intracellular signaling molecules that amplify the inflammatory response. An understanding of oxidative stress involved in this disease might allow the use of antioxidant therapies in the prevention and/or treatment of knee osteoarthritis.
Source: http://www.ncbi.nlm....pubmed/20120698

[Logic]

How to make your own C60HYFN by bcelliott - Ph.D. on fullerenes:

The method is fairly straightforward, though you need a horn ultrasonicator for best results. Without getting into the nitty gritty details, a layer of low to medium concentrated filtered C60-toluene solution is layered on top of a much larger volume of water, and directly sonicated near the interface for several hours while controlling the temperature. The sonic energy should not be too high or you'll lose too much product to a hard-to-separate emulsion. You can either wait until the toluene evaporates or use a separation funnel to recover the aqueous portion, which is yellow. Then you filter, concentrate as you wish, and filter again. If done correctly, the solution should be yellow and transparent, since most of the product will be tiny clusters of water-complexed C60 from 1-3 molecules, with a small percentage as larger clusters. The THF method (which is the only one to show toxic effects in organisms) and other methods such as direct mixing into water yield much larger clusters from 30-200 nm in size. The sonication from toluene method seems to be the best to produce bioavailable, non-toxic product since the single fullerenes are already fully solvated by toluene at relatively low concentrations in that solvent, and the sonic energy simply exchanges the solvent for water.

Buying second-hand lab equipment to make this product is far less expensive than buying it from Ukraine! It is a lot more work than C60-OO, however, and what remains to be seen is if there are advantages to the HyFn when compared with the oil-solubilized version.
http://www.longecity...fullerene-hyfn/


A cheap sonicator:
http://www.artisticd....com/ulfog.html
 

[smithx]

Rheumatoid arthritis is considered to be an auto-immune syndrome. It has recently been successfully treated with n-acetyl glucosamine (not regular glucosamine!). A starting dose is probably about 2g twice a day. 

 

See these references:

http://www.newscient...=mg19426074.500

http://www.ncbi.nlm....pubmed/22434264

 

n-acetyl glucosamine also treats multiple sclerosis and other auto-immune diseases. 

http://www.scienceda...10930123057.htm

 

 

[smccomas01]

Smithx thanks for posting this, now the question is where to find. 

[niner]

Smithx thanks for posting this, now the question is where to find. 

 

Swanson USED TO have it, but no mas.   I went to reorder, and it was gone.  I guess I should bug them about it, because I just googled it, and other people have it.  There's a site called LuckyVitamin.com, for example, that has Jarrow NAG for a good price.

Edited by niner, 27 February 2015 - 01:00 PM.

[fntms]

Iherb has the jarrow NAG.

Any source for 4.5mg naltrexone? Is the ADC stuff ok? (you would have to grind the 50mg pills though...)

[smccomas01]

fntms check your inbox 

[smithx]

Here's iHerb's NAG page with a few options:

http://www.iherb.com...tyl-glucosamine

 

[gatornoot]

What dose are you using?

Interested since I also have RA.

Dosage recommendation seems to be 600mg twice a day, then 300mg twice a day thereafter.

We've been talking about several different substances in this thread; what are you talking about here? I'd hate to see someone take 600 mg of Naltrexone and die of a seizure or something...

This was in reference to the Palmitoylethanolamide we were discussing previously. Just checking if anyone's tried this.

[Astroid]

Carbon60 in Olive OIL or C60OO is not approved for human internal use in any country as far as I know or has that changed recently?

 

 

HaHa.. LIke I need approval from any educated idiot.  Like one can trust the Medical or Scientific "EXPERTS"...  Sorry I am independent and think for myself... Screw your approval BS.

 

"Captain" David