6 replies to this topic

[Logic]

"...Antimicrobial resistance is a huge problem, but we might finally have the upper hand in this power struggle between man and bug - a new antibiotic called teixobactin, which has been shown to kill a wide range of drug-resistant bacteria in lab mice, including those responsible for tuberculosis and septicaemia, plus Clostridium difficile colitis (C. dif) - the most common gut bug infection...

...The secret to Teixobactin’s success is that it prevents microbes from being able to construct their cell walls, and holes in your cell walls means certain death. In fact, the antibiotic ended up killing 100 percent of the bacteria it came into contact with, and no survivors means there's no one to evolve resistance...

...it only works against bacteria that lack outer cell walls, known as Gram-positive bacteria..."
http://www.scienceal...ered-since-1987

Now this, along with DRACO should give one's immune system a huge break.
http://www.longecity...infected-cells/

[StevesPetRat]

This will kill you.

A gut stripped of gram positive bacteria (lactobacillus, bifidobacteria, clostridia, bacillus, etc.) is gonna be lethal. I doubt you could scarf down probiotics fast enough to replace them. IV administration might lessen the impact on the gut, though.

[Danail Bulgaria]

Unfortunately sooner or later the microbes will develope resistence to it too.

 

It seems, that this is our fate - never ending cycle

 

1) make a new antibiotic

2) pour it to the mindless crowd

3) microbes become resistent to it

4) go to step 1)

 

It will not be a problem, if we can always make new antibiotics, but who knows?

 

Edited by seivtcho, 22 January 2015 - 09:30 AM.

[Logic]

Ph.D. student Shu Lam, lead researcher, University of Melbourne:

“We’ve developed a new class of antimicrobial agents, which are very unique. They come in the form of tiny star-shaped molecules that are made from short chains of proteins,” Lam told VICE. “We found that they are very effective at wiping out [bacterial] infections in mice and they are also relatively non-toxic to the body.”

http://www.deprogram...ers-way-to.html

 

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

...we show that a class of antimicrobial agents, termed ‘structurally nanoengineered antimicrobial peptide polymers’ (SNAPPs) exhibit sub-μM activity against all Gram-negative bacteria tested, including ESKAPE and colistin-resistant and MDR (CMDR) pathogens, while demonstrating low toxicity. SNAPPs are highly effective in combating CMDR Acinetobacter baumannii infections in vivo, the first example of a synthetic antimicrobial polymer with CMDR Gram-negative pathogen efficacy. Furthermore, we did not observe any resistance acquisition by A. baumannii (including the CMDR strain) to SNAPPs. Comprehensive analyses using a range of microscopy and (bio)assay techniques revealed that the antimicrobial activity of SNAPPs proceeds via a multimodal mechanism of bacterial cell death by outer membrane destabilization, unregulated ion movement across the cytoplasmic membrane and induction of the apoptotic-like death pathway, possibly accounting for why we did not observe resistance to SNAPPs in CMDR bacteria. Overall, SNAPPs show great promise as low-cost and effective antimicrobial agents and may represent a weapon in combating the growing threat of MDR Gram-negative bacteria.

http://www.nature.co...techstories.org

 

[Nate-2004]

Ph.D. student Shu Lam, lead researcher, University of Melbourne:

“We’ve developed a new class of antimicrobial agents, which are very unique. They come in the form of tiny star-shaped molecules that are made from short chains of proteins,” Lam told VICE. “We found that they are very effective at wiping out [bacterial] infections in mice and they are also relatively non-toxic to the body.”

http://www.deprogram...ers-way-to.html

 

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

...we show that a class of antimicrobial agents, termed ‘structurally nanoengineered antimicrobial peptide polymers’ (SNAPPs) exhibit sub-μM activity against all Gram-negative bacteria tested, including ESKAPE and colistin-resistant and MDR (CMDR) pathogens, while demonstrating low toxicity. SNAPPs are highly effective in combating CMDR Acinetobacter baumannii infections in vivo, the first example of a synthetic antimicrobial polymer with CMDR Gram-negative pathogen efficacy. Furthermore, we did not observe any resistance acquisition by A. baumannii (including the CMDR strain) to SNAPPs. Comprehensive analyses using a range of microscopy and (bio)assay techniques revealed that the antimicrobial activity of SNAPPs proceeds via a multimodal mechanism of bacterial cell death by outer membrane destabilization, unregulated ion movement across the cytoplasmic membrane and induction of the apoptotic-like death pathway, possibly accounting for why we did not observe resistance to SNAPPs in CMDR bacteria. Overall, SNAPPs show great promise as low-cost and effective antimicrobial agents and may represent a weapon in combating the growing threat of MDR Gram-negative bacteria.

http://www.nature.co...techstories.org

 

This is all over my head, what does this mean?

[PeaceAndProsperity]

Unfortunately sooner or later the microbes will develope resistence to it too.

 

It seems, that this is our fate - never ending cycle

 

1) make a new antibiotic

2) pour it to the mindless crowd

3) microbes become resistent to it

4) go to step 1)

 

It will not be a problem, if we can always make new antibiotics, but who knows?

You develop resistance by being less function. Cops cannot handcuff you if you don't have hands. But without hands you won't survive well. Eventually they won't be able to loss more functionality in favor of resistance.

[Danail Bulgaria]

Evolution knows its job.

 

It will find a way the microbes to be both deadly and resistent.