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Fat busting drug

fat busting drug pill victorian tetrahydrocannabinol csiro

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#1 PWAIN

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Posted 13 August 2015 - 01:01 PM


Anyone know what chemical they are referring to here? Looks like something worth looking into.


http://www.heraldsun...3-1227480977589


A PROMISING discovery by Victorian scientists could lead to the development of a fat pill within five years.

The new research findings by Deakin University shows that in the laboratory, they can shut down two pathways that are activated by cannabis and vitamin A, reducing the build-up of fat.

The next step is to test the drugs’ effectiveness in overweight animal models to see if they can stop weight gain or ­reverse it and identify any ­potential side effects, before they move into human trials.

Lead researcher Dr Yann Gibert, the head of Metabolic Genetic Diseases Research Laboratory in Geelong, said they also wanted to determine if the drugs could be used as a preventive measure or treatment for obesity.


index

Successful trials could see the pill available within five years.

It is well known that the ­active ingredient in marijuana, tetrahydrocannabinol (THC), makes people hungry, but it also plays a role in fat ­formation.

Dr Gibert said they wanted to see if blocking the endocannabinoid system, the pathway that cannabis activates, and the retinoic acid pathway, which involves vitamin A, could reduce fat formation.

“We found that blocking both pathways has the potential to treat obesity in a safer and more effective way than shutting down each independently,” Dr Gibert said.

“We do not know yet whether it can reverse the build-up of fat or block it.

“That will be a key question for the next stage of the ­research.”

He described the findings, published in the journal Endocrinology, as an exciting ­development that could form part of the solution to reducing the obesity epidemic.

“The magic pill for obesity may exist, but I don’t think it will ever involve just one compound, it will be a combination drug,” Dr Gibert said.

He said if the trials progressed positively, they could lead to a drug being available within five to 10 years.

CSIRO researchers are ­investigating how to design weight-loss diets that are tailored to our genetic make-up.

Scientist Dr Nicholas Archer said our food preferences were determined by our health, diet, prior experience and genes.

By better understanding why some people have a sweet tooth, hate their greens or crave fatty foods, it would ­enable diets or food products to be personalised to individual preferences.

 



#2 Niccoló

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Posted 13 August 2015 - 03:24 PM

I'll tell you how "to design weight-loss diets that are tailored to our genetic make-up." Eat less, move more, that will do, pig.

 

 

On a side note, I'd put my money on a

  • DNP (most effective fat burner in existance, past, current and future)
  • T3 (exernal thyroid hormone)
  • Modafinil/ECA (for energy mainly)
  • Sibutramine (against the insane hunger you get on DNP/T3)

stack anyday.  

 

Note of caution: If you fuck this up, there is a very high chance of dying a horrible death. And don't go running to the hospital, because they won't be able to save you, your organs are going to boild and overheat and that's it for you...

 

Most people who die from diet-supplements die from one of the substances I listed. I highly recommend you to not use this stack!

 

On the other hand I did use it and I kid you not within 14 days I went from fat to sixpack. Whenever I show people the pictures they agree that I look like a posterboy for a "90 day transformation with this cool new supplement"


Edited by Niccoló, 13 August 2015 - 03:26 PM.


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#3 Kalliste

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Posted 14 August 2015 - 05:20 AM

Have not heard of it before. There was another pill in the news a while ago that aimed at making fatty membranes harder to peroxidize by introducing heavy water:

 

 

olstering cells with a dose of heavy fat may be the key to curing degenerative diseases. And it may help you hold back the years

COULD a shiny orange capsule of modified fat help to keep you young? For the first time next month, fats designed to reinforce our cells against age-related damage will be given to people in a clinical trial. The participants have a rare genetic disorder, but if the treatment works for them, it could eventually help us all live longer, more youthful lives, says the scientist behind the work.

Mikhail Shchepinov, director of Retrotope, a biotech company based in Los Altos, California, wants eventually to slow down the ageing process. But he is starting with a related problem – treating the inherited movement disorder Friedreich's ataxia, with which ageing shares a mechanism. They are both caused, in part, by a molecular attack on our cells. Shchepinov's idea is to counteract this assault by reinforcing our cells' defences, slowing the progression of this incurable disease. If it works, it should demonstrate that the approach is also suitable for tackling ageing.

The damage he wants to address is caused by molecules called oxygen free radicals, made when our cells metabolise. Free radicals have unpaired electrons that desperately try to find a partner by tearing electrons off other molecules. This triggers a chain reaction as the denuded atom then does the same to its neighbour.

This chain reaction is particularly dangerous for the fatty acids that form our cell membranes. "They burn like gunpowder until hundreds of thousands are damaged," says Shchepinov. Proteins and DNA also come off badly. Blocking the reaction should prevent the damage, but Shchepinov has a different idea.

 

 

He reckons we can protect our cells from free radicals simply by strengthening the bonds between molecules that make up our cell membranes. This can be done by swapping the hydrogen in the fatty acids for a different form known as deuterium. Because deuterium has an extra neutron, it is heavier than hydrogen and forms stronger bonds (see "The skinny on heavy fat").

Enter the modified fat pill. The idea is that substituting some of the fats we normally eat with modified, stronger fats in pill-form should allow us to build stronger cells. To test the idea, Shchepinov and his colleagues developed heavy versions of an omega-6, polyunsaturated fatty acid. "It's not a nutrient – it's a new chemical that is different from the fats you get in your diet," says Retrotope co-founder Robert Molinari, the biochemist who is leading the clinical trial.

The approach works in yeast – samples that metabolised heavy fats appear to be up to 150 times as resistant to the oxidative stress caused by free radicals as those given regular fatty acids.

The next step is to see whether heavy fat can slow the progression of Friedreich's ataxia. This is caused by free radical damage to the nerves responsible for movement and usually means people are wheelchair-bound within 10 to 20 years of symptoms appearing. The idea makes sense, says Corinne Spickett at Aston University in Birmingham, UK. "The underlying chemistry is quite correct – the fats are theoretically less susceptible to attack by free radicals," she says.

The trial launching in June is a safety study. The team will be checking that the doses of heavy fat are well tolerated by 18 people with Friedreich's ataxia. They don't expect problems – even if every cell membrane were made from their modified fatty acids, the total amount of deuterium in the body would still be around four times lower than a dangerous dose.

At first, each volunteer will be given two 1 gram tablets of heavy fat per day. "It looks like a fish oil pill," says Molinari. After a break, the dose will be ramped up, with people taking five tablets, twice a day. Because the heavy fats need to overwhelm the fats we usually get in our food, the volunteers will be placed on a special diet. "They can have olive oil and saturated fats but not polyunsaturated fatty acids," says Shchepinov.

Reverse the damage

Molinari hopes that the treatment will not only halt the progression of the disease, but also improve people's symptoms. By replacing cellular fatty acids with stronger ones, there is a chance of rescuing nerves that are sick, but not dead. "A degree of reversal of damage is possible," he says. "We see improvements in cell experiments – we won't know about the effects in people until we do the trial." Although a larger trial will be needed to determine any effect on symptoms, the team is hoping to see some hints during the safety study.

"The principle is sound, and some beneficial effects of heavy fats have been seen in cells and rodents," says Spickett. "But will this translate to humans? We'll have to see."

Theoretically, heavy fats could also prove useful in other diseases in which free radicals are implicated, such as Parkinson's. A few years ago, Shchepinov and colleagues at the University of Arkansas and the Scripps Research Institute in California, found that a diet rich in heavy fats protected mice against the worst ravages of the mouse equivalent of Parkinson's disease.

 

When I'm reading about nano-antioxidants I note some teams are trying to use that as a way to combat fat accumulation. But with the potential ROS disturbance of Neural stem cells I wonder how that is going to work:

 

 

Pharm Res. 2014 Nov;31(11):2952-62. doi: 10.1007/s11095-014-1390-7. Epub 2014 May 8.
Cerium oxide nanoparticles inhibit adipogenesis in rat mesenchymal stem cells: potential therapeutic implications.
Abstract
PURPOSE:

Cerium oxide nanoparticles (nanoceria, NC) have extraordinary antioxidant activity that made them suitable as a therapeutic agent for several diseases where reactive oxygen species (ROS) act by impairing the normal redox balance. Among different functions, it has been proven that ROS are cellular messengers involved in the adipogenesis: we thus investigated the implication of NC administration in the potential inhibition of adipogenic differentiation of mesenchymal stem cells (MSCs) used as a model of adipogenesis.

METHODS:

We evaluated cytotoxic effects and adipogenic maturation of mesenchymal stem cells following in vitro NC administration, both at gene and at phenotype level.

RESULTS:

Overall, our results demonstrated that NC efficiently inhibit the maturation of MSCs toward adipocytes owing to their ability to reduce the production of the ROS necessary during adipogenesis.

CONCLUSIONS:

These findings, even if preliminary, represent an important step toward the potential pharmaceutical application of NC in the treatment of obesity.

 

In the end I wonder what will overcome obesity? Kurzweil was talking about blocking the FIR pathway with genetic engineering back in 2005. I think it's going to be something like that. Not a pill.



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#4 niner

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Posted 15 August 2015 - 03:10 AM

I wouldn't bet on this endocanabinoid / retinoid work.  It's too early in the process, for one thing-- it sounds like they don't have much (any?) data.  These are very fundamental signalling pathways, and it would be easy to screw something up.  Most people would be better off losing the 64 ounce Big Gulp ® High Fructose solution if they want to lose weight.


  • Agree x 1





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