it didnt really answer what i asked but thanks
NORMALIZING: Sorry to hear that you have a problem with Choline, as important as it is. Do you have the same problem with lecithin?
I appreciate your answers to my questions. Appears you have the experience with Lion's Mane supplements and I can understand that you feel the Amyloban 3339 is a scam, especially if you are less than 60 years old. I believe that the younger of age the less effective some of these neurotropic substances will be. At what age or point does one need to start using them to be effective against aging/degeneration of various areas of the body/brain (not that they are separate).
I looked last night and did not put my hands on research that finally spoke about real dosage of the active components but I remember for hericenones it was always micrograms/Kg body weight. Therefore the =+0.5% hericenones in the Amyloban 3339 product is probably in line with dosage but it does not allow calculating anything; really inadequate. It appears that not one company wants to state what the dosages are.
I have become side tracked looking at these Lion's Mane products online and I did find a couple, contrary to REAL MUSHROOMS insistence, that do specify the PERCENTAGE (only) of the beta-glucans. Not getting anywhere. It appears the pricing for mycelium based products, which should be the main contributor of NGF simulator /synthesizing ability, is about $0.40/gram, again leading nowhere as to actual erinacines - good. I believe on eBay there was a Chinese seller who obviously does not know better and listed toxic metal analysis, and all sorts of details except the actual range of erinacines and hericenones.
What to do? I think that these product sellers are marketers for the most part and do not want to spend any money on addressing the content in their product of the active compounds. BUT I think things would change if everyone took a moment and went onto, for instance, Amazon.com and asked questions. I have on several products and get some reply. If the companies see that people are asking the right questions some one of them might give the answers and/or start labeling and doing the analysis. I would think that with the background of the fungi perfecti owner and his access to a great laboratory, he would publish his products active ingredients contents instead of only what the product derived from.
I assume that everyone reading these posts understands that China geology contains the largest and most wide spread deposits of about all of the rare earth metals and many of the toxic heavy metals besides that class. The aquifer is contaminated with these. Extensive mining and intrusive extraction without regulation has caused the largest contamination area on the planet. I doubt if it is possible to obtain any products from China that do not exceed some toxic metal values. This is a real and present danger.
Answering your question: most of the medicinal mushrooms grow on wood in nature, decomposing wood. Fungi were created to decompose cellulose, primarily. Their spores "seeds" spread via wind and insects, some spiders and the like too. Trees species that support Lion's Mane, oak for instance, utilize iron and organic metals from the ground into their cell structure. These are hard woods and they have metal in them. The utilization of toxic metals that are harmful to humans may also occur in trees, obviously if they are toxic to the tree it will not live nor be absorbing much very long. Fungi/mushrooms growing on the ground are generally not growing on the "earth" they are growing on dung "poop" and/or decayed cellulose/trees, leaves, branches - doing their thing; decomposing cellulose. What ever is in the cellulose, some of that is going to be in the fungi. Not all, but obviously some of those substances.
I know that this thread is about Lion's Mane, conditionally VERDICT ON LIONS MANE, meaning what? Peoples experience, outcome/result, observations, etc. using it, correct? Like for the NGF aspect, as it has many other properties also, but probably for the NGF. So stepping out a bit I would like to share that another fungi was found to stimulate NGF synthesis in humans and here is some data points on that and few other substances that "boost" NGF to boot. Maybe in the future there will be some thread(s) to follow too.
http://www.ncbi.nlm..../pubmed/9272967 - Dictyophorines A and B, two stimulators of NGF-synthesis from the mushroom Dictyophora indusiata.
Also Know As: Phallus indusiata (causes orgasmic reaction to smelling these in some women but not any men).
ALSO to increase NGF:
- Huperzine A an herb-derived alkaloid that seems to boost NGF
- 20 minutes of certain yoga meditation elevates NGF secretion
- Polygala tenuifolia a Chinese herb shown to increase NGF secretion in astrocytes
- Therapygenetics - showing how NGF genes predict treatment outcome to cognitive behavioural therapy
AND not to stop but a good read is this:
Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. (2015, Aug.) = http://www.ncbi.nlm....pubmed/26244378
"...this overview surveys and consolidates the widely scattered literature on the chemistry (isolation and structural characterization) of polysaccharides and secondary metabolites such as erinacines, hericerins, hericenones, resorcinols, steroids, mono- and diterpenes, and volatile aroma compounds, nutritional composition, food and industrial uses, and exceptional nutritional and health-promoting aspects of H. erinaceus.
The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds include antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipodemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression. The described anti-inflammatory, antioxidative, and immunostimulating properties in cells, animals, and humans seem to be responsible for the multiple health-promoting properties.
A wide range of research advances and techniques are described and evaluated. The collated information and suggestion for further research might facilitate and guide further studies to optimize the use of the whole mushrooms and about 70 characterized actual and potential bioactive secondary metabolites to help prevent or treat human chronic, cognitive, and neurological diseases."
Cheers.