LONGECITY

J147 was recently in the news as a treatment for Alzheimer's and a potential anti-aging drug, but the press releases were sparse on details.  There were photos of a strain of mice bred to age rapidly, looking svelt and young when compared to controls.

 

This is what seems to be known about J147's mechanism of action:  induces neurotrophic factors NGF (nerve growth factor) and BDNF.  That is about all, the mice seemed healthier than the controls.  Perhaps it is over-hyped?

 

Dihydromyricetin is well known as an anti-intoxicant, via GABA antagonism: it binds to GABA receptors, blocking alcohol from binding, but not activating them,  But Dihudromyricetin (DHM) has another effect: it stimulates irisin via PGC-1alpha, which causes release of BDNF in the brain

 

Sounds a bit like J147t there are more studies on DHM than on J147.  In addition, DHM has been called an exercise mimetic in that it induces conversion of fat to brown (energy burning)  fat, as does exercise. There are also studies showing DHM is a liver protectant, improves glucose metabolism, and has anti-cancer properties. 

 

DHM is available on Amazon, at reasonable prices and appears to be quite safe.  The available J147 substances are questionable as to identity, and seem to be at best inactive substances. Plus they are quite expensive.

 

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Dihydromyricetin stimulates irisin secretion partially via the PGC-1α pathway.

 

i remember people discussing Dihydromyricetin  just preventing the high from alcohol but doing absolutely nothing else like helping alcohol withdraw, so im not sure how is blocking the euphoria from alcohol a good thing anyway?? just so you dont drink? but then, how do you feel when you are withdrawing if that stuff doesnt help that either? seems like a useless thing to take.

Gives you a clear head.  Taken before drinking you don't get dizzy and uncoordinated, though I wouldn't say you'll feel exactly sober.  After a few drinks you tend to sober up, at least as far as the worst effects of drinking are concerned.  It appears to protect the liver, similarly to silymarin, and ameliorates the toxic effect of acetaldehyde on the liver, which helps counteract the effects of a hangover.  A DJ in Montreal I met, tried it before going to work about midnight.  He usually has a few drinks while working, and reported his head was totally clear the next day.  He'll use it again.   If you are a female whose date is trying to get her drunk, you'll find it useful.  IF you are playing poker and drinking and don't want to lose your shirt, you'll find it helpful.  Even if you don't drink, I think the above quoted studies a number of other possible benefits.

DHM is great for hangovers. A little scary great, actually. By scary I mean it could turn you into an alcoholic if you really love drinking but stop only because you hate hangovers. If I take DHM before drinking I'll still get drunk and feel about the same. It's the hangover that it cures -- at least for me.

I really had no idea it had any other benefits. Exercise mimetic? That's pretty neat.

maxwatt, whats its potential as alcohol withdraw tho, does it have benefit to take instead of drinking?

The herbs from which dihydromyricetin is extracted have been used to treat alcohol withdrawal for over a century.

Edited by maxwatt, 05 December 2015 - 12:57 PM.
entioned wrong substance

I'm just joining the dots here.
Another exercise mimetic; SR-9009, increases mitochondria in muscle:
http://www.longecity.../82848-sr-9009/

So i'm curious, has anyone tried this for benzo withdrawal ? should be interesting to know 

 

 

Also im attaching a studie on Flavonoids and action´s of the different compounds , but its a bit heavy for me but maybe someone else will have greater use for it 

 

https://www.research...a7a27000000.pdf