10 replies to this topic

[Iamnobodi]

I have been experiencing no libido since November 2013 now, and have found no cure to this significant ailment in my life. I am 22 male, and I find this quite distressing. 

 

I have seen 2 urologists. First urologist tested my testosterone, LSH, and FSH hormones. Results were

 

LH (luteinizing hormone): 2.68 units mIU/ml

FSH follicle stimulating hormone): 1.53 units mIU/ml

Testosterone: 5.96 ng/ml (reference range 1.42 - 9.23) 

 

According to the urologist, these results demonstrate that there is nothing wrong. Second urologist I saw prescribed me viagra. I asked for further testing such as free testosterone, prolactin, estradiol  but he said based on the results that I got from the first urologist it wasn't needed. 

 

So now I am thinking whether it could be due to past MDMA use that I could be experiencing low libido and mimicking post SSRI effects that some people experience: 

 

http://rxisk.org/bur...sfunction-pssd/

 

I think I may have experienced serotonin syndrome over a year ago from taking E so maybe that night could be the culprit behind my presently non-existent libido? 

 

I have completely stopped all drugs, and keep alcohol to a minimum for a over a year now. With the exception of taking M 7 months ago once. I have a healthy lifestyle, work out 4 times a week. 

[gamesguru]

Probably, google image "mdma binding" or "mdma binding 5-ht1a".  Lots of overlap in many regions.  Remember 5-HT1A is thought to mediate PSSD.  And mdma-induced serotonin syndrome might cause a similar dysfunction of the 5-ht1a system, and cell death, possibly worse than ssri-induced.

 

The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucleus in high densities, while low amounts also exist in the basal ganglia and thalamus.[3][4][5] The 5-HT1A receptors in the raphe nucleus are largely somatodendritic autoreceptors, whereas those in other areas such as the hippocampus are postsynaptic receptors.[4]

[Iamnobodi]

I have really fucked myself up. I have a bad feeling, it's for good. 

[gamesguru]

Diet and exercise can undo some cell death, or at least dendrite death.

Ginkgo is 5-ht1a antagonist, might help.

Green tea can target the nigrostriatal bundle, that's affected by mdma.

You have options...

 

Besides, impotence and loss of libdo occurred in some young men long before ssris and mdma, suggesting a genetic component in certain cases.

[Iamnobodi]

Thanks for your replies, Guru. 

Hmm, I've been leading a healthy lifestyle for the past 7 months with the exception of some binge drinking. However I now plan to cut out alcohol completely. 

 

My situation has not improved. I guess the best thing for me is to accept my non-existent libido and completely forget about women 

[gamesguru]

Better to identify a cause of the problem, and an appropriate solution than to assume, on little knowledge, the situation is unchangeable.  I'm not smooth with women, due to variable mood/reduced empathy/poor self-identity (BPD), darkness (depression), and fear (SAD/AvPD)... 23 y/o, kissless.  I'm not throwing in the towel tho.  Have to develop your weaknesses slowly, incrementally, over the years.

 

http://www.healthlin...ido#Depression5

It could be depression, schzio, or PD (for depression, a more finely tuned diet works wonders).

Cancer, viral load/CFS, RLS

Low test, or medications (obvs ssris, but many more too)

It could be stress, poor eating schedule, lack of sleep.

Edited by gamesguru, 12 February 2016 - 05:58 PM.

[Baten]

My situation has not improved. I guess the best thing for me is to accept my non-existent libido and completely forget about women 

Heya. When I met my girlfriend I had no libido. I dreaded her initiating sex since I couldn't really respond to it in the state I was (myriad of reasons, never did drugs like mdma though). I took cialis (generic, India) to get by since I couldn't do without. Over time (timespan 6 to 12 months showed great progress) I regained my libido. I work out 3 times a week, take cold showers, eat/live real healthy, quit watching porn near daily to very occasionaly as in hardly ever. I would have never gotten this far if it wasn't for my girlfriend sticking with me though (although I never told her I took drugs to help, I think it doesn't matter if she knows; easier if she doesn't). It's so much easier to get back what you're missing 'bonding' with someone, cheesy but true. Best of luck with your recovery. Don't lose hope !

Edited by Baten, 12 February 2016 - 08:57 PM.

[sativa]

I have really fucked myself up. I have a bad feeling, it's for good.

Not really man, everything is resolvable.

MDMA depletes VMAT which is a crucial part of normal neurotransmitter release, so one idea would be to increase VMAT levels. Lobelia inflatable is one such method, it does this by causing VMAT2 upregulation from VMAT2 inhibiton (so best to sleep through the inhibition phase!)

Iboga is the king of brain neurochemistry restoration. Its illegal in the US though. Its neuropharmacology is fantastic!

Memantine, Theanine, Zinc, Magnesium, agmatine,garlic ,apigenin and other NMDA antagonists will also help you by significantly resetting your brains tolerancea to both endogenous and exogenous substances. Memantine boosts cognition very nicely.

Zinc should also increase libido due to its pro dopamine actions which will lower prolactin (due ti inverse relationship with dopamine)

n-acetylcysteine will likely be of use to you, it's great for enhancing dopamine functionality.

Adaptogens will also help to restore brain and body functioning. Jiaogulan for example (see www.longecity.org/forum/topic/67585-17-random-dopaminergic-supplements/)

Vitamin E is a good prolactin inhibitor. I use the dry succinate form. High prolactin tends to reduce libido.

Also, possibly try increasing testosterone levels! Nettle root contains a safe and effective aromatase inhibitor.

Another possible tactic would be to reduce exposure to synthetic estrogen mimicking chemicals. Notably from plastics (heat + food + plastic is definitely a big NO!) Look at your shampoo ingredients for suspicious chemicals with potential hormonal effects.

Fluoride and polyunsaturated fats will reduce thyroid function which will slow down your metabolism and make you sluggish and possibly gain weight.

Gluten and casein metabolites activate opiate receptors which might play their own role in your issues (assuming you eat gluten foods or dairy).

Edited by sativa, 12 February 2016 - 11:22 PM.

[Flex]

 

I have really fucked myself up. I have a bad feeling, it's for good.

Not really man, everything is resolvable.

MDMA depletes VMAT which is a crucial part of normal neurotransmitter release, so one idea would be to increase VMAT levels. Lobelia inflatable is one such method, it does this by causing VMAT2 upregulation from VMAT2 inhibiton (so best to sleep through the inhibition phase!)

Iboga is the king of brain neurochemistry restoration. Its illegal in the US though. Its neuropharmacology is fantastic!

 

Lobelia is according to this source an inhibitor of Vmat2.

http://www.ncbi.nlm....pubmed/24484975

 

Please keep in mind that Iboga can be fatal even in normal doses due to a Vagus-nerve overstimulation (or something like that) the shamans induce therefore a state of trance to avoid it.

Therefore never do this alone.

 

@ OP

I´ve read that MDMA damages dopamine and serotonine terminals.

It would look for some reports whether anyone else has experieced the same symptoms as You. I´ve only read about a reduction of libido.

 

anyway, my approach would be to find out possible differences in Your symptoms vs. PSSD in oder to to be more certain about the cause.

The thing in PSSD is a constant & elevated tone of Serotonine because the presynaptic (auto)5-ht1a receptors, which shut the release of Serotonine upon activation, are faulty (permanent desentitized).

 

As an result, the postsynaptic 5-ht1a as well as other are overactivated, which is why Zinc (not more than 30mg/day! b/c of vasoconstriction) might help because it reduces pre- and postsynaptic 5-ht1a transmission as well as elevates SERT expression, which increases the clearance of Serotonine. 

 

Besides the suggested Zinc, I would also try buspar which activates only the "pre" 5-ht1a ones at lower-mid doses.

However it doesnt work that good for people with PSSD anyway and it wouldnt heal You.

 

- for dopamine, You could try mucuna pruriens aka L-Dopa. If You experience hughe improvements,

then its probably not PSSD b/c afaik Serotonine deactivates dopamine-neurons via the post 5-ht1a. <- Admitely I´m unsure about this

 

This doesnt counts for synthetic Dopamine  agonists where Ropinirole helps against PSSD.

Try to avoid them b/c of Dopamine Agonist Withdrawal Symptoms (DAWS)

http://www.longecity...ws/#entry648504

 

- One further thing that dont "afaik" work for PSSD are 5-ht2a inhibitors which should work b/c those ones do also control the Libido

 

So I would look whether You´re having constant low dopamine and/or high Serotonine via behavioral changes like elevated shyness, more or lesser anxiety &etc.

 and therefore You could take a look at the reports in the pssdforum and look for further possible differences and common symptoms

Edited by Flex, 15 February 2016 - 02:28 AM.

[sativa]

Please keep in mind that Iboga can be fatal even in normal doses due to a Vagus-nerve overstimulation (or something like that) the shamans induce therefore a state of trance to avoid it.
Therefore never do this alone.

Ah, and forgot to indicate I was referring to microdosing iboga extract.

I use a fill spectrum iboga liquid extract and take 1-4 drops occasionally for neuronal maintenance. I do not worry about any side effects at this dose

[jroseland]

Worth a watch for any young men with this kind of issue...

Edited by jroseland, 01 March 2016 - 01:29 PM.