8 replies to this topic

[lemon_]

Hi all,

 

May you give advice on what supplements to take for Alcoholism please?.

no fluff.

 

 

thank you.

[niner]

Do you want something to help you stop drinking, or something to protect you so that you can keep drinking?  Or a little of both?

[lemon_]

both please, sir. 

[640ng]

N-acetylcysteine before you drink 600mg for liver protection.

[lemon_]

anything else? 

[mwestbro]

Kudzu:

 

1. Psychopharmacology (Berl). 2013 Mar;226(1):65-73. doi: 10.1007/s00213-012-2884-9.
Epub 2012 Oct 16.

A standardized kudzu extract (NPI-031) reduces alcohol consumption in
nontreatment-seeking male heavy drinkers.

Lukas SE(1), Penetar D, Su Z, Geaghan T, Maywalt M, Tracy M, Rodolico J, Palmer
C, Ma Z, Lee DY.

Author information:
(1)Behavioral Psychopharmacology Research Laboratory/MIC, Mail Stop 319 McLean
Hospital, 115 Mill Street, Belmont, MA 02478, USA. Lukas@mcLean.harvard.edu

OBJECTIVE: We previously demonstrated that short-term treatment with a
standardized kudzu extract (NPI-031) reduced alcohol drinking by men and women in
a natural setting. The present study was conducted in nontreatment-seeking heavy
drinkers to assess the safety and efficacy of 4 weeks of kudzu extract in an
outpatient setting.
METHOD: This randomized between-subject, double-blind, placebo-controlled study
involved 2 weeks of baseline, 4 weeks of treatment, and 2 weeks of follow-up.
Seventeen men (21-33 years) who reported drinking 27.6 ± 6.5 drinks/week with a
diagnosis of alcohol abuse/dependence took either kudzu extract (250 mg
isoflavones, t.i.d.) or matched placebo on a daily basis. They reported alcohol
consumption and desire to use alcohol using a wrist actigraphy device; twice
weekly laboratory visits were scheduled to monitor medication adherence and
adverse events.
RESULTS: Medication adherence was excellent and there were no adverse events and
changes in vital signs, blood chemistry, and renal or liver function. There was
no effect on alcohol craving, but kudzu extract significantly reduced the number
of drinks consumed each week by 34-57 %, reduced the number of heavy drinking
days, and significantly increased the percent of days abstinent and the number of
consecutive days of abstinence.
CONCLUSIONS: A standardized formulation of kudzu extract produced minimal side
effects, was well-tolerated, and resulted in a modest reduction in alcohol
consumption in young nontreatment-seeking heavy drinkers. Additional studies
using treatment-seeking alcohol-dependent persons will be necessary to determine
the usefulness of this herbal preparation in reducing alcohol use in other
populations.

PMCID: PMC3562758
PMID: 23070022 [PubMed - indexed for MEDLINE]

 

It isn't a supplement, but AA helps also.

[Darryl]

Prescription gabapentin worked well to reduce both ruminative thoughts and craving for me. A review:

 

Leung JG et al. 2015. The role of gabapentin in the management of alcohol withdrawal and dependence. Annals of Pharmacotherapy, 49(8), pp.897-906.

 

If you're curious about mechanism.

 

Hendrich J et al. 2008. Pharmacological disruption of calcium channel trafficking by the α2δ ligand gabapentin. Proceedings of the National Academy of Sciences,105(9), pp.3628-3633.

[Dorian Grey]

PPC (polyenylphosphatidylcholine) "PhosChol" completely prevented advanced liver disease in alcoholic baboons...  

 

http://www.ncbi.nlm..../pubmed/2258155

 

"These results indicate that some component of lecithin exerts a protective action against the fibrogenic effects of ethanol. Because we had previously found that choline, in amounts present in lecithin, has no comparable action, the polyunsaturated phospholipids themselves might be responsible for the protective effect."

 

A second study confirmed, it was the DLPC (found in substantial amounts only in PPC) component that provided the protection.

 

http://www.ncbi.nlm....pubmed/11866479

 

"Dilinoleoylphosphatidylcholine is responsible for the beneficial effects of polyenylphosphatidylcholine on ethanol-induced mitochondrial injury in rats"

 

SAM-e is another liver supplement superstar...

 

http://ajcn.nutritio...76/5/1183S.full

 

Edited by synesthesia, 18 February 2016 - 02:04 AM.

[Dorian Grey]

Here's another clue for you all...  (the walrus is IRON)

 

Give these topics a google: 

 

Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease

Iron Overload: An Important Co-Factor In The Development of Liver Disease in Alcoholics

Iron accumulation in alcoholic liver diseases

The Role of Iron in Alcoholic Liver Disease

Liver Iron is Predictive of Death in Alcoholic Cirrhosis

Serum ferritin concentration predicts mortality in patients awaiting liver transplantation

 

Iron accumulation is a major contributor to alcoholic liver disease, and not all that hard to fix.  Get thee to a blood bank!  Blood donation is the fastest and easiest way to lower iron. Donate "whole blood" only; plasma or platelet donations do not lower iron! 

 

A "ferritin" iron lab is the best way to diagnose alcohol or age related iron accumulation.  The lab values range up to 300 for the upper limit for ferritin in many labs, but this is the threshold for clinical iron overload.  Optimal ferritin levels are best kept below 100, particularly in populations who are drinking, and/or experiencing liver inflammation.  

 

Natures iron chelators are: IP6, Curcumin, & Quercetin.  

Edited by synesthesia, 21 February 2016 - 09:10 AM.