Well I have a high level of confidence that liposomally encapsulated trehalose will make it through the gut without being broken down into glucose as normally happens to almost all trehalose passing through the digestive tract.
The only question for me would be does that encapsulated trehalose translate into trehalose crossing the BBB, which would be of interest to you if you are trying to treat some neurodegenerative brain disorder (Parkinson's, Huntington's, Alzheimer's, etc). Certainly I don't believe the liposomes will cross the BBB themselves, but I suspect that there are mechanisms where at least some of the trehalose released from the liposomes will make it across.
I however am more interested in the anti-atherosclerosis aspect of trehalose, and I don't think there's much of a question that we can deliver significant quantities of trehalose to the arterial wall through liposomal encapsulation. I'm looking for a commercial source now and barring progress there will try to make some up myself.
Someone earlier suggested enteric capsules. But enteric coating only gets a target compound through the stomach. They are designed to release their delivery drug in the small intestines. But, that's exactly where trehalose is broken down, it is not digested in the stomach, so I don't see that helping us much.
Edited by Daniel Cooper, 22 December 2017 - 07:00 PM.