3 replies to this topic

[lemon_]

Hi,

 

What should one take with melatonin to make it increase its effects?.

anything chemically melatonin  related?...

 

 

magnesium?

[PeaceAndProsperity]

Beneficial effects in what sense? For aging? For sleep?

[lemon_]

for all 

[Mind_Paralysis]

Valproic Acid.

 

It upregulates MT -receptors and improves sleep-quality. It's mostly used as an on and off -thing though, unless you've got Bipolar and are taking Agomelatine at the same time.

 

"Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain."
http://www.ncbi.nlm....ubmed/22243807/

"Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells."
http://www.ncbi.nlm....pubmed/16313512

"Regional upregulation of hippocampal melatonin MT2 receptors by valproic acid: therapeutic implications for Alzheimer's disease."
http://www.ncbi.nlm....pubmed/24909617

"Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation."
http://www.ncbi.nlm....pubmed/17303109

 

Daaamn... I'm goooood...!

Always been a bit proud of this one - finally figuring out how to reverse Agomelatine and melatonin -tolerance - in the best possible way!