1 reply to this topic

[Logic]

Dasatinib kills of senescent cells that should have died off and been replaced but hang around causing inflammation/'inflamaging' and all its associated issues.
 
A combination of Dasatinib and the common supplement Quercetin was found to be synergistic in removing these rogue cells with a tremendous impact on quality of life and the burden of age-related chronic diseases.
 
New class of drugs dramatically increases healthy lifespan by killing of senescent cells:

"...The team suspected that senescent cells' resistance to death by stress and damage could provide a clue. Indeed, using transcript analysis, the researchers found that, like cancer cells, senescent cells have increased expression of "pro-survival networks" that help them resist apoptosis or programmed cell death. This finding provided key criteria to search for potential drug candidates.
Using these criteria, the team homed in on two available compounds -- the cancer drug dasatinib (sold under the trade name Sprycel®) and quercetin, a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.
Further testing in cell culture showed these compounds do indeed selectively induce death of senescent cells. The two compounds had different strong points. Dasatinib eliminated senescent human fat cell progenitors, while quercetin was more effective against senescent human endothelial cells and mouse bone marrow stem cells. A combination of the two was most effective overall...dramatically slows the aging process -- alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan..."

https://www.scienced...50309144823.htm

 

You can read more here:

http://www.longecity...nds-healthspan/

NB Fafner55's and others' rather dramatic success with this protocol.

 

The group buy thread is here:

http://www.longecity...e-2#entry791009

 

Fafner55 has very kindly offered to cover the financial difference between a minimum order and the commitments received so this buy is definitely going to happen!

Please post a commitment to the amount you want in grams in the group buy link above if you would like to join.

 

 

[Johnny Adams]

Moderator: I searched for the best place on the form for this.  If there is a better location, please send me an email with details.

 

RE Dasatinib testing -- Information about ordering testing for dasatinib and rapamycin, and other compounds

 

Information about ordering testing for purity and content of dasatinib and rapamycin, and other compounds, has been created. 

 

That info, and a lot more that's needed for their safe use, would make for a very long post.  So it’s all in the document in the link below.

 

There is one question about qualitative versus quantitative testing applicable to our purposes.  Perhaps you will investigate this further and get back to us.

 

https://www.agingint.../Senolytics.pdf