Ok, this doesn't jive... Methylcobalamin, TMG, folate, and riboflavin were said to slow telomere attrition and people got longer telomeres with AIV and TA65/Cycloastragenol. So what's the rate of TA65 efficacy? How many base pairs are being added and how long would it take to replace lost telos? 16% is that in a year or over the lifetime of the patient? What is the starting age? Is transparent information available? I'd hate to see young people age unnecessarily and not make use of technologies so they could be sold more products when they are more aged and the age at which you start is likely to be very important to the efficacy of the product. Why shouldn't people under 25 use this product? Telomeres start shortening around 17 iirc. Wouldn't telomere maintenance be most productive in young people? Or young people just don't have that kind of money to spend?
Personally, I take 50mg/day of cycloastragenol. I don't take it continuously due to the expense, but eventually I may, and faster dosing would be expected to show results in a more timely manner.
Does anyone have more information on this? Is a diagram of the molecule available?
Its 16% of the amount of telomerase activation that it takes to immortalize an adult human cell line. Now cells that are senecent or close to have slower turnover rates, and thus slower telomere attrition rates, and that is probably the reason that some of them had their telomeres lenghtened by something as mild as TA65.
So in other words, it will cost $5,600 a month to take enough to escape telomere attrition ($800/bottle/month *7)? I need to make at least $67k/yr just to fix my telomeres? I wonder if I can just drink stem cell culture media with meals... I guess I could take the whole bottle over the course of 4-5 days, once a month and take cycloastragenol the rest of the days ($9,600/yr)... How dose dependent is this stuff? What's the LD50?
How long until the next iteration comes out?
As far as stopping attrition or reversing it altogether by taking massive amounts of a low level telomerase activator like TAM818 or TA65, I don't think it works like that. At some point there's gotta be diminished benefits and tolerance for any single molecule. I wouldn't try it. Unless you're really getting up there in age and have a lot of disposable cash, then maybe.
I understand that, but sometimes you have to think in terms of the impossible to find the possible. There are plenty of complexes that produce stunning results that exceed the potential of the individual components. If TA65 stops working at some point, it's because you run out of cofactors. So what pathways do we need to leverage and beef up in order to get TA65 to perform like the Yamanaka Factors in terms of telomere extension? Monotherapy thinking will never get us to immortality. We need to think in relational and hierarchical systems if we are to succeed.
So TA65 extends telos on critically short chromosomes... Do we need to waste time on those? Or can we just kill them off with apigenin? Apigenin is a p53 activator (p53 shortens telos), but it also lengthens telomeres. So it would appear that senolytics (assuming it is one given it is similar to quercetin in function) remove the underperformers, then the telomere extenders can concentrate on improving the healthier cells. Is it important to extend critically short telomeres? Astragaloside IV can be equal in potency to TA65 and it's cheaper. Is TAM818 just a mashup of Astragaloside IV and apigenin? Perhaps acetylated?
Can we get more TA65 into more areas of cells by taking it with EDTA? Will it spontaneously acetylate if they are in the same capsule and we wash it down with dilute ethanol? In a broad sense, that should give it more access to our metabolism, but what's next? Can we take it with thymine, adenine, guanine, and cytosine? I know these have been used as drugs to inhibit viral transcription, but they are also the building blocks of telomeres, which are TTAGGG/AATCC repetitions, so perhaps we can simply overload our metabolisms with that ratio (balanced).
How do we down regulate Shelterin and TERRA? How do we up regulate nonsense mediated decay factor? Increase CST Complex Proteins? Increase Telomerase Reverse Transcriptase?
There are lots of pathways which we can enhance to delimit telomere growth potential. Assuming we get it right and complex it with enough other stuff to enhance DNA repair mechanisms, the sky is the limit. Nothing is impossible! Even if we make mistakes, if we've regenerated our thymus, removed senescent cells, repaired our DNA, replaced damaged mitos with good ones, our innate and active immune systems will more than readily be able to clean up after us! That's why I have such a problem with the worship of overpriced mono-actives. If it's going to cost $9,600/yr for the TAM818, how much is it going to cost for each of the rest? Will we ever get appreciable results? For my money, I'll strategically complex the cheap stuff and buy a few bottles of the expensive stuff periodically to see if it's worth waiting for a price drop.