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Extremely sensitive to tryptophan after serotonin syndrome, help please

serotonin syndrome serotonin toxicity tryptophan

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#1 nostalgic

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Posted 29 August 2017 - 05:09 PM


About 5 weeks ago I experienced serotonin syndrome (ssri combo) although only a mild version of it, and I still can't believe how sensitive my brain is yo anything that increases serotonin.
Since then I've taken 12,5mg Hydroxyzine and got a worsening of symptoms within 15 mins, which lasted for days even though I'm on bcaa and a low tryptophan diet. About a week ago I took a few bites of millet to see how I tolerated it and had to stop when I felt the toxicity starting to build up (that time I didn't take any bcaa).

About 5 days ago I added hydrolysed collagen to my diet to get enough protein, I started very slow and on the 5th day I took a full dose and noticed my symptoms getting worse, and it turns out sucralose increases serotonin, so now I can't eat that either.

I've ordered unflavored hydrolysed collagen from the states and that should work at least but it won't arrive before 3-4 weeks.

I'm afraid I might be permanently damaged and the doctors don't do anything to help. I've never read of such extreme sensitivity to serotonin, hence why I fear this might be permanent.

My symptoms are not that severe thankfully or else I dunno what I'd do. Am I screwed? Thank you for reading.

#2 sant2060

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Posted 29 August 2017 - 05:31 PM

What are your symptoms?

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#3 nostalgic

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Posted 29 August 2017 - 05:50 PM

What are your symptoms?

 

I appreciate you replying. I've had minor muscle twitching ever since this hell started, and pretty apathetic but I don't mind the apathy that much, I actually welcome it atm.

 

When I eat something I react to I start sweating, get anxiety, the twitching gets worse, tingling sensation in face, arms, and legs, nausea, headache, diarrhea, muscle pain, stomach pain, hot skin etc, so many I can't remember them all.

 

When I ate the small amount of millet and stopped, I didn't get nausea or headache, and the lingering symptoms barely worsened.


Edited by nostalgic, 29 August 2017 - 05:54 PM.


#4 PeaceAndProsperity

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Posted 29 August 2017 - 06:11 PM

Do you have irritability and fatigue?



#5 nostalgic

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Posted 29 August 2017 - 06:14 PM

Do you have irritability and fatigue?

I suffer from CFS but I notice a bit more fatigue, I'm irritable from CFS as well and it's not gotten worse from this.

#6 PeaceAndProsperity

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Posted 29 August 2017 - 06:35 PM

One of the most obvious signs of excessive serotonin levels is irritability and fatigue. CFS is strongly linked to the 5ht2a serotonin receptor.



#7 nostalgic

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Posted 29 August 2017 - 07:00 PM

One of the most obvious signs of excessive serotonin levels is irritability and fatigue. CFS is strongly linked to the 5ht2a serotonin receptor.

I didn't know, thanks for the info. Any idea about my extreme sensitivity?



#8 PeaceAndProsperity

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Posted 29 August 2017 - 07:35 PM

No, I have it as well. Extreme sensitivity to serotonin and glutamate.



#9 nostalgic

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Posted 29 August 2017 - 07:38 PM

No, I have it as well. Extreme sensitivity to serotonin and glutamate.


Sorry to hear that. How did yours start? And what works for you?

#10 PeaceAndProsperity

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Posted 30 August 2017 - 03:16 PM

 

No, I have it as well. Extreme sensitivity to serotonin and glutamate.


Sorry to hear that. How did yours start? And what works for you?

 

Always been like this. I think when I was 2 or 3 years old I was known for being very irritable, hence serotonin sensitivity. It's genetic.

 



#11 Aurel

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Posted 30 August 2017 - 11:10 PM

How long did your syndrome last and at what daytime did it occur?



#12 nostalgic

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Posted 30 August 2017 - 11:26 PM

How long did your syndrome last and at what daytime did it occur?


It didn't last for that long, less than a day acutally, but I've still got muscle spasms and some emotional numbness, and I return to toxicity way too easily.

No, I have it as well. Extreme sensitivity to serotonin and glutamate.

Sorry to hear that. How did yours start? And what works for you?
Always been like this. I think when I was 2 or 3 years old I was known for being very irritable, hence serotonin sensitivity. It's genetic.

Have you tried cyproheptadine or any other serotonin antagonist?

#13 Aurel

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Posted 30 August 2017 - 11:41 PM

Sometimes I get the same symptoms as you but for a much shorter time (around an 1h). I am also on SSRI. At that times I also have the strange feeling of diarrhea. Sucralose also affects your gut biome. Have you checked that road out? Some good books on the gut-brain came out the last couple of years.



#14 nostalgic

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Posted 31 August 2017 - 12:58 AM

Sometimes I get the same symptoms as you but for a much shorter time (around an 1h). I am also on SSRI. At that times I also have the strange feeling of diarrhea. Sucralose also affects your gut biome. Have you checked that road out? Some good books on the gut-brain came out the last couple of years.

Haven't delved into anything else but the brain, but it's definitely possible you're onto something here.

The question remains though: is there anything I can do about it or will I just have to live with it? Or will it possibly correct itself in time?

#15 Aurel

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Posted 31 August 2017 - 01:49 PM

I still have to find that out for myself and then I don't know if it would be apply to you. But if your case is also connected to the gut, then it would be possible to reverse. "Brain Maker" by Perlmutter is a good start and read on that topic.

 

Keep open for other possibilities for your problem though.



#16 nostalgic

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Posted 31 August 2017 - 01:58 PM

I still have to find that out for myself and then I don't know if it would be apply to you. But if your case is also connected to the gut, then it would be possible to reverse. "Brain Maker" by Perlmutter is a good start and read on that topic.

Keep open for other possibilities for your problem though.


I don't think it's related to the gut seeing as it started with a serotonin syndrome that won't fully recover.

If it's related to the brain does that mean I'm incurable?

#17 PeaceAndProsperity

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Posted 31 August 2017 - 02:11 PM

It is not connected to the gut lol... obviously. Stupid fad culture.

There are serotonin receptors outside the brain, in the heart, in the gut, etc., and that is why you can get diarrhea, heart palpitations or a heavy beating heart when you have too much serotonin.

 

As for myself I have yet to have diarrhea or constipation from serotonin but I do get symptoms related to the heart, my heart beating heavily like I've gained 50 pounds.

 

I believe the issue with SSRIs is they downregulate the serotonin autoreceptor, which causes paradoxically an even greater sensitivity to serotonin after "treatment". How you resolve this mess I don't know but as far as I read it may involve an autoreceptor antagonist to resensitize it, or something. There are forums for SSRI-induced sexual dysfunction and there you will find all the experiments and research people do on themselves.

 



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#18 nostalgic

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Posted 31 August 2017 - 02:42 PM

It is not connected to the gut lol... obviously. Stupid fad culture.
There are serotonin receptors outside the brain, in the heart, in the gut, etc., and that is why you can get diarrhea, heart palpitations or a heavy beating heart when you have too much serotonin.

As for myself I have yet to have diarrhea or constipation from serotonin but I do get symptoms related to the heart, my heart beating heavily like I've gained 50 pounds.

I believe the issue with SSRIs is they downregulate the serotonin autoreceptor, which causes paradoxically an even greater sensitivity to serotonin after "treatment". How you resolve this mess I don't know but as far as I read it may involve an autoreceptor antagonist to resensitize it, or something. There are forums for SSRI-induced sexual dysfunction and there you will find all the experiments and research people do on themselves.


Thanks, I'll give that a look. I tried a micro amount of Cyproheptadine, a rough estimate of 0.1mg and even that low of a dosage was too much for my brain, so maybe it's better to give the body a few months to heal and if it doesn't get any better at all I can test if my brain accepts the pills better by then.





Also tagged with one or more of these keywords: serotonin syndrome, serotonin toxicity, tryptophan

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