Hello, I finally got around to testing vitamin B5 and pregnenolone for increasing testosterone and other male hormones.
My hypothesis is that while pregnenolone orally and transdermally is useless for increasing androgens (proven in studies), pregnenolone applied directly to the testicle area is not useless because pregnenolone's metabolism to androgens happens only locally in the testicles and oral consumption or transdermal application (elsewhere) does not cause pregnenolone to circulate to the testicles in any significant amount.
My second hypothesis is that since vitamin B5 increases activity of the 5 alpha reductase enzyme, which metabolizes testosterone to other androgens, application of vitamin B5 to the testicle area can increase testosterone metabolites.
My third hypothesis is relevant to phosphatidylserine (only from animal brain, soy source doesn't work) and increasing 5 alpha reductase in testicles (some rat study) but I don't have it at hand, I will soon buy it and test it perhaps.
Just 30 minutes ago I took a 500mg vitamin B5 and 10mg pregnenolone capsules (with fillers) and added it to a small dmso solution. I marinated my testicles in the solution until no liquid or powder was left in the jar and here's what I noticed:
1. Immediately I felt a need to urinate.
2. Reddening and itching of my sac.
3. Usual disgusting garlic taste in mouth.
4. PERHAPS, MAYBE a tiny sedative effect. I am not sure so don't take it for anything.
I cannot feel that I have taken pregnenolone or b5, although oddly most other supplements I mix with dmso do produce their usual brain effects immediately.