Wellbutrin + Modafinil combo
kurdishfella
24 Feb 2018
Has anyone looked at this combo? Both have long half lifes. Wellbutrin increases norepinephrine but weakly on Dopamine only 20% inhibition on DAT(dopamine transporter). So Modafinil according to wikipedia its mechanism of action is to inhibit DAT and I think thats all it does that is known. At 300mg it inhibits 50% DAT . So the two together wellbutrin and modafinil produce over 70% DAT inhibition and increase dopamine neurotransmission all day with their long half lifes = good constant Anti-Depressant effect.
Edited by farshad, 24 February 2018 - 02:43 PM.
justmodz
07 Mar 2018
the combination of modafinil with wellbutrin and other anti depressants has been seen in studies which show that it is effective and reduces depression and give the edge back to life
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