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supplements for polycystic kidney disease.

regimens

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3 replies to this topic

#1 Gnumf

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Posted 14 April 2012 - 04:01 PM


hi
i have polycystic kidney disease. Do you know any supplements to support kidneys or specifically for this disease?
thanks
i already take CQ 10

#2 tunt01

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Posted 14 April 2012 - 04:50 PM

this is probably a good starting point:

http://naturalmedici...MJ_SEP10_TC.pdf

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#3 Lufega

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Posted 15 April 2012 - 05:02 AM

peppermint tea is very effective for lowering testosterone and magnesium seems to make all menstrual related problems a lot easier.

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#4 hippocampus

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Posted 18 April 2012 - 11:02 PM

@lufega: what has PKD to do with menstruation?

curcumin looks promising, although no humans studies has been done yet.

Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model
Autosomal dominant polycystic kidney disease (ADPKD) caused by mutations in either the PKD1 or PKD2 gene is a major cause of end-stage renal failure. A number of compounds targeting specific signaling pathways were able to inhibit cystogenesis in rodent models and are currently being tested in clinical trials. However, given the complex signaling in ADPKD, an ideal therapy would likely have to comprise several pathways at once. Therefore, multitarget compounds may provide promising therapeutic interventions for the treatment of ADPKD. To test this hypothesis, we treated Pkd1-deletion mice with diferuloylmethane (curcumin), a compound without appreciable side effects and known to modulate several pathways that are also altered in ADPKD, e.g., mammalian target of rapamycin (mTOR) and Wnt signaling. After conditional inactivation of Pkd1, mTOR signaling was indeed elevated in cystic kidneys. Interestingly, also activation of signal transducers and activator of transcription 3 (STAT3) strongly correlated with cyst progression. Both pathways were effectively inhibited in vitro by curcumin. Importantly, Pkd1-deletion mice that were treated with curcumin and killed at an early stage of PKD displayed improved renal histology and reduced STAT3 activation, proliferation index, cystic index, and kidney weight/body weight ratios. In addition, renal failure was significantly postponed in mice with severe PKD. These data suggest that multitarget compounds hold promising potential for safe and effective treatment of ADPKD.

→ source (external link)


I also think that I've read somewhere that omega-3 are good, but they are good for everything anyway :D (well, omega 3: omega 6 ratio to be exact).





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