4 replies to this topic

[Avatar of Horus]

A review article:

The aging process and potential interventions to extend life expectancy
Clin Interv Aging. 2007;2(3):401-12.
Tosato M, Zamboni V, Ferrini A, Cesari M.
Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy.
pubmed: http://www.ncbi.nlm....pubmed/18044191
full article: http://www.ncbi.nlm..../pmid/18044191/

Abstract
Aging is commonly defined as the accumulation of diverse deleterious changes occurring in cells and tissues with advancing age that are responsible for the increased risk of disease and death. The major theories of aging are all specific of a particular cause of aging, providing useful and important insights for the understanding of age-related physiological changes. However, a global view of them is needed when debating of a process which is still obscure in some of its aspects. In this context, the search for a single cause of aging has recently been replaced by the view of aging as an extremely complex, multifactorial process. Therefore, the different theories of aging should not be considered as mutually exclusive, but complementary of others in the explanation of some or all the features of the normal aging process. To date, no convincing evidence showing the administration of existing "anti-aging" remedies can slow aging or increase longevity in humans is available. Nevertheless, several studies on animal models have shown that aging rates and life expectancy can be modified. The present review provides an overlook of the most commonly accepted theories of aging, providing current evidence of those interventions aimed at modifying the aging process.

Keywords: Aging, anti-aging medicine, caloric restriction, oxidative damage, inflammation, physical exercise

In this article the various theories of aging are overviewed:
Evolutionary theory of aging
Free radical theory of aging
Mitochondrial theory of aging
Gene regulation theory of aging
Telomere theory of aging
Inflammation hypothesis of aging
Immune theory of aging
Neuroendocrine theory of aging
Neuroendocrine-immuno theory of aging
Caloric restriction

[ymc]

Huntington disease mentioned in the article can be eliminated by widespread PGD. Alzheimer caused by APOE can also be eliminated that way.

[GetMaxed]

I just came across this one today, Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of AgingAntioxid Redox Signal. 2010 February 15;


The main one I wanted to mention is the Redox Stress Theory of Aging, which does ties into many of the other aging theories, as they all do.

The best peer-reviewed article on the subject can be found at http://www.ncbi.nlm....les/PMC3267846/ Free Radic Biol Med. 2012 February 1

I've also done my own extensive write up on it at http://danielcampagn...-gsh-cysteine-1 which elaborates further on some topics.

[Avatar of Horus]

I just came across this one today, Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of AgingAntioxid Redox Signal. 2010 February 15;


The main one I wanted to mention is the Redox Stress Theory of Aging, which does ties into many of the other aging theories, as they all do.

The best peer-reviewed article on the subject can be found at http://www.ncbi.nlm....les/PMC3267846/ Free Radic Biol Med. 2012 February 1

I've also done my own extensive write up on it at http://danielcampagn...-gsh-cysteine-1 which elaborates further on some topics.

Your writing is a good treatise of the subject, this redox theory.

I am currently working on experiment designing for anti-aging, life extension interventions, approaching from the extracellular environment/matrix and cell signaling direction.
Its topic: Human and Mouse Life Extension DIYBio Stem Cells Experiment
http://www.longecity...lls-experiment/

You, too, write that additional research and experiments would be good for further checking.
Have you, by any chance, some ideas or suggestions for testing,
and/or could you write some words (here or in that topic or PM) about that
how this redux dysregulation theory, or your view on it, pertains to my approach:
my topic's parts where it is discussed:
post #25: heart and cardiovascular system section
with the studies of:
Torella et al. 2004
Ungvari et al. 2011
Bailey-Downs el at. 2012

and
post #31: heart section.

[GetMaxed]

I just came across this one today, Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of AgingAntioxid Redox Signal. 2010 February 15;


The main one I wanted to mention is the Redox Stress Theory of Aging, which does ties into many of the other aging theories, as they all do.

The best peer-reviewed article on the subject can be found at http://www.ncbi.nlm....les/PMC3267846/ Free Radic Biol Med. 2012 February 1

I've also done my own extensive write up on it at http://danielcampagn...-gsh-cysteine-1 which elaborates further on some topics.

Your writing is a good treatise of the subject, this redox theory.

I am currently working on experiment designing for anti-aging, life extension interventions, approaching from the extracellular environment/matrix and cell signaling direction.
Its topic: Human and Mouse Life Extension DIYBio Stem Cells Experiment
http://www.longecity...lls-experiment/

You, too, write that additional research and experiments would be good for further checking.
Have you, by any chance, some ideas or suggestions for testing,
and/or could you write some words (here or in that topic or PM) about that
how this redux dysregulation theory, or your view on it, pertains to my approach:
my topic's parts where it is discussed:
post #25: heart and cardiovascular system section
with the studies of:
Torella et al. 2004
Ungvari et al. 2011
Bailey-Downs el at. 2012

and
post #31: heart section.

Thanks. My reference to further experiments to test was in relation to this section http://www.ncbi.nlm....63/#__sec8title

While GSH/GSSG is the major intracellular redox couple, in the extracellular environment cysteine/cystine (Cys/CySS) is the major redox couple and would be a good one to measure. The articles I've referenced in the section "The Redox Shift with Age" on my blog post would be the ones to look into in relation to your study. I've only had a quick look over it, I'll have to find some more time to read it thoroughly.

Regards,

Dan