6 replies to this topic

[Bateau]

Just compiling a list of random COX-2 inhibitors. Benifits of some COX-2 inhibitors aside from the obvious decreases in inflammation and inflammatory pain range from cancer prevention to prevention of cognitive decline (such as cognitive decline from THC).

This list is of supplements only and is missing pharmaceuticals like Celecoxib and OTC's like Aspirin and Ibuprofin, which tend to come with cardiovascular complications. This list is not all inclusive. Please mention any missed COX-2 inhibitors.


Fish Oil (DHA & EPA)
Resveratrol
Pterostilbene
Piceatannol
Pycnogenol
Blueberry/Bilberry
Pomegranate
Curcumin/Turmeric
Ginger
Garlic
Black Cumin
Green Tea Catechins
Theaflavins
Yerba Mate
Spirulina
White Mulberry
Gotu Kola
Bacopa
Holy Basil
Echinacea
Aloe Vera
Siberian Ginseng
Stinging Nettle
Quercetin
Genistein
Psoralea corylifolia
Cissus quadrangularis
Apigenin
Eucommia ulmoides
Bromelain
Guggul
Tribulus terrestris
Thunder God Vine
Sesamin
Butea monosperma
Uncaria rhynchophylla

Edited by Bateau, 22 January 2014 - 09:16 PM.

[joelcairo]

Berberine
Melatonin
Silibinin
Chamomile
CAPE
Thyme

However I wonder if a shotgun approach to reducing COX-2, if dramatically successful, wouldn't produce those same cardiac side effects. It seems to me that part of the problem is that the inflammation is what identifies damaged tissue for repair.

[Steve Zissou]

I was under the impression that specific cox 2 inhibitors had worse cardiovascular risks than non specific cox inhibitors.

[Bateau]

Yes the cardiovascular concern is a legitimate one, which is why its been mentioned in every post so far. However I am having a hard time believing that a stack consisting of say Fish Oil, Berberine, Resveratrol, Garlic, Spirulina, and Pomegranate would have the same cardiovascular concerns as say Celecoxib. These are some of the most promising cardiovascular supplements currently being provided.

Even Aspirin is used to PREVENT heart attacks and strokes, the exact cardiovascular concerns that COX-2 inhibitors are related to.

Simply because something inhibits COX-2 does not mean that it comes with the same concerns as modern, overly-potent, non-pleiotropic pharmaceutical selective COX-2 inhibitors. That's what is called a grand oversimplification. There's literally hundreds of studies on the cardiovascular benefits of Aspirin, Fish Oil, Berberine, Resveratrol, Garlic, Spirulina, Pomegranate, Green Tea Catechins, Blueberries, Turmeric etc. etc. that fly in the face of the theory that these might increase cardiovascular concerns. Its a bit of a "forest for the trees" situation when it comes to supplements this pleiotropic.

Edited by Bateau, 23 January 2014 - 05:18 PM.

[hav]

Don't forget Lactuca sativa... aka, lettuce.

Howard

[joelcairo]

BTW, my intention wasn't to cast doubt about phytonutrients, but to defend Celebrex and other NSAIDs. At the standard 200 mg level of Celebrex, there is no measurable cardiotoxicity and enormous measurable benefits. At higher levels there is some minor risk, and I really don't see why taking large amounts of, say, 5 or 10 items from the above list could not carry the same minor risk.

See this meta analysis of studies, showing that even a 400 mg dose once per day comes with only slight, not statistically significant risks:
http://pmmp.cnki.net...08-149-3-15.pdf

There was a real disaster with Vioxx and doctors have been antsy about them ever since, but IMO NSAIDs are not necessarily to be avoided.

Edited by joelcairo, 23 January 2014 - 06:53 PM.

[joelcairo]

... Before anybody calls me on the "enormous measurable benefits" claim, see for example the clinical studies below, where regular use of COX-2 inhibitors reduces the risk of numerous types of cancer anywhere from 30% to 70%:

Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review).
http://europepmc.org...ct/MED/15756426

Long-Term Use of Nonsteroidal Anti-inflammatory Drugs Decreases the Risk of Cutaneous Melanoma
http://www.nature.co...jid201158a.html

Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
https://www.dovepres...hp?fileID=13617