Would it be worth trying to get my hands on Stablon or Coaxil or no? Also, what would the most cost-effective source be? How long would a 3-gram supply of tianeptine last?
Also, my doctor recommended vortioxetine (Brintellix). It has some 5-HT3 antagonism, so I was wondering if that might be beneficial for someone with sensitive gut serotonin receptors?
I can only say that tianeptine doesn't seem to negatively effect my cognition at all, so I would go with it over another antidepressant. In fact it doesn't seem to make me feel much different at all, just less stressed. When I tried an SSRI it was noticeable and weird, but who knows if that was just abnormal.
5-ht3 antagonism should be helpful though yes. See: https://en.wikipedia...rome#Medication
heres a study on tianeptine vs. amitriptiline for IBS:
http://www.ncbi.nlm....pubmed/22679908
"At week 4, non-inferiority of the tianeptine group to the amitriptyline group (treatment difference -15.1%; 95% CI -26.6% to -3.8%) was shown, with 81.1% (99 of 122 patients) of the patients in the tianeptine group and 66.0% (70 of 106 patients) in the amitriptyline group reporting global relief of IBS symptoms. The secondary endpoints also demonstrated non-inferiority of the tianeptine group to the amitriptyline group. Adverse events such as dry mouth and constipation were significantly lower in the tianeptine group than the amitriptyline group (P<0.05)."
I use ~20mg twice a day. So.. 25days per gram, 75 days with 3 grams. But maybe just get one gram to see if it works for you. Its pretty cheap anyway I guess though.