I also appreciated your last point regarding PSA/Q10 and I report a study below.
Again I can only rely my experimenting and experience. I recently decided to increase to 100mg my Ubiquinol intake. On the free fatty acid panel I try to have a good balance. I was found deficient in GLA and D-GLA (both omega-6, GLA is rapidly converted to D-GLA) so I decided to supplement GLA moderately (only 1/2 of the serving, i.e. 150mg) and try to limit D-GLA cascading (*) to the pro-inflammatory arachidonic acid using EPA/DHA. For the latter I only very limited supplement with fish oil as definitively prefer to eat fresh fatty fishes. Again I will run a full free fatty acid panel next summer to check. (Chronic) Inflammation is really bad for the prostate so everything you can do to reduce it is good. Next to the above, I specifically use curcumin, zyflamend, pomegranate and green tea extracts.
This a study referring to this matter:
http://www.ncbi.nlm....pubmed/23199523
Abstract
“The main objective of the present study was to determine the potential of n-3 and n-6 fatty acids or coenzyme Q10 (CoQ10) to alter serum prostate-specific antigen (PSA) levels in normal healthy men. A total of 504 healthy men with serum PSA level ≤ 2•5 ng/ml were recruited into the study. Serum PSA values were not segregated by decade of age. Participants were randomly assigned to a daily dietary supplement containing n-3 fatty acids (1•12 g of EPA and 0•72 g of DHA per capsule) (group 1, n 126), n-6 fatty acid (600 mg γ-linolenic acid (GLA) each capsule) (group 2, n 126), CoQ10 (100 mg per capsule) (group 3, n 126) or a similar regimen of placebo (group 4, n 126) for 12 weeks. Study medication was administered as two capsules to be taken twice daily. Serum levels of PSA, EPA, DHA, GLA, lipid profile and reproductive hormones were also measured. EPA treatment significantly reduced serum PSA level by 30•0 (95 % CI 25, 36) % (P= 0•004) from baseline. In contrast, GLA therapy significantly increased serum PSA concentration by 15•0 (95 % CI 11, 20) % (P= 0•02). CoQ10 therapy also significantly reduced serum PSA level by 33•0 (95 % CI 27, 40) % (P= 0•002). In multivariable analysis, serum values of PSA were strongly correlated with duration of EPA (r - 0•62; 95 % CI - 0•42, - 0•77; P= 0•003), n-6 (r 0•42; 95 % CI 0•31, 0•58; P= 0•02) and CoQ10 use (r - 0•77; 95 % CI - 0•56, - 0•87; P= 0•001). There were also significant correlations between serum values of DHA, EPA, GLA and CoQ10 and serum PSA levels. The present study demonstrates that dietary supplements containing EPA, GLA or CoQ10 may significantly affect serum PSA levels.”
(*) I learned from Dr. Sears (The Anti Inflammation Zone), this is done by an enzyme (delta-5-desaturase), activated by insulin and inhibited by EPA, lignans from sesame oil (already contained in my GLA supplement) and tumeric.
Edited by albedo, 16 December 2014 - 09:22 AM.