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so aspirin's got competition (ibuprofen)

anti aging aspirin ibuprofen steroid

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#1 eon

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Posted 19 December 2014 - 12:28 PM


 
"Researchers found that all species lived about 15 percent longer when treated with ibuprofen, and the worms and fruit flies appeared to behave in a healthier manner."
 
"Further studies led to the conclusion that ibuprofen inhibits uptake of tryptophan and other amino acids by the cell. Tryptophan is an amino acid that’s an essential building block of proteins, but also involved in the regulation of “the calming hormone,”  serotonin, and it is vital for health across organisms."
 
“Ibuprofen slows the transport of amino acids, and the protein synthesis slows down,”   Kennedy tells Yahoo Health. Slower protein synthesis equals slower aging — which equates to increased longevity across all the species."
 
Are there ways of slowing protein synthesis other than popping ibuprofen? Is there such a thing as "baby" ibuprofen like there is a "baby" aspirin?
 
Before we all start popping ibuprofen, there are steps we can take according to the article;
 
- Control inflammation (considering ibuprofen is an NSAID, anti inflammatory, I would think steroids would be much superior unless you aren't into bulking?). 
 
- Retain muscle mass (again, what could be better than steroids? Also there was an article a few years back that for you to look pumped up, popping an NSAID after workout works, perhaps healthier since it controls inflammation after workout. I've tried it but like I said, I think steroids would still be superior. Its status and associated stigma may be a problem to some people. I think light doses would be fine? I have used them before which is why it's easy for me to say, maybe stack HGH there somewhere?).
 
And more interesting facts about ibuprofen:
 
 "Ibuprofen's discovery was the result of a research during the 1950s and 1960s that was looking for a safer alternative to aspirin." Does this mean it is safer than Aspirin? Let's see...
 
- "In some studies, ibuprofen showed superior results compared to a placebo in the prevention of Alzheimer's disease, when given in low doses over a long time."
 
- "Ibuprofen has been associated with a lower risk of Parkinson's disease, and may delay or prevent it. Aspirin, other NSAIDs, and paracetamol (acetaminophen) had no effect on the risk for Parkinson's.
 
- "In March 2011, researchers at Harvard Medical School announced in Neurology that ibuprofen had a neuroprotective effect against the risk of developing Parkinson's disease."
 
- "People regularly consuming ibuprofen were reported to have a 38% lower risk of developing Parkinson's disease, but no such effect was found for other pain relievers, such as aspirin and paracetamol."
 
 
I just looked up if there was an opioid drug with an ibuprofen combo and found that Combunox is the first and only one with a 5 mg oxycodone and 400 mg ibuprofen combo, interesting find because the Percocet I have is a combo with acetaminophen. Why I never looked into this before!
 
 
 
 

Edited by eon, 19 December 2014 - 12:53 PM.

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#2 Kalliste

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Posted 20 December 2014 - 06:36 AM

Reason-bot posted this in the Biosciencenews forum. Tldr: Dont pee your pants over this.



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#3 JohnD60

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Posted 21 December 2014 - 06:23 PM

You are confusing Corticosteroids which are used as anti-inflammatories with Anabolic Steroids which are used for muscle bulking


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#4 eon

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Posted 22 December 2014 - 06:41 AM

I'm not sure what you're getting at but corticosteroids have serious side effects. As with anything they are dose dependent. But as for steroids, it heals you up faster than NSAID. I've never seen a steroid retailer sell corticosteroids. Seems like it has different actions than steroids and NSAIDs.

 

 

You are confusing Corticosteroids which are used as anti-inflammatories with Anabolic Steroids which are used for muscle bulking

 



#5 JohnD60

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Posted 22 December 2014 - 07:18 AM

 

I'm not sure what you're getting at but corticosteroids have serious side effects. As with anything they are dose dependent. But as for steroids, it heals you up faster than NSAID. I've never seen a steroid retailer sell corticosteroids. Seems like it has different actions than steroids and NSAIDs.

 

 

You are confusing Corticosteroids which are used as anti-inflammatories with Anabolic Steroids which are used for muscle bulking

 

 

Your really don't understand what I was getting at? In your original post you suggested using anabolic steroids as an anti-inflammatory. Bulking steroids, aka anabolic steroids are not anti-inflammatory. It is completely baseless to recommend anabolic steroids be used as an anti-inflammatory. The type of steroids that are used as anti-inflammatories are Cortiosteroids (which have no bulking effects).
 



#6 eon

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Posted 22 December 2014 - 08:27 AM

OK maybe my view of steroid as anti-inflammatory due to it repairing the muscles after a workout since strenuous exercise breaks down muscles thus needs repair. I would think steroids would also control or prevent inflammation. My use of steroids never made me feel I was ever in pain or have any body aches maybe it's why I suggested and considered steroids to be anti-inflammatory.


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#7 treonsverdery

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Posted 05 January 2015 - 09:00 PM

Visiting the yahoo link to the research on ibuprofen causing greater longevity at three different species is pleasant

 

I heard or read that coadministrastion of apirin with ibuprofen actually reduces the reduction of cyclooxgenase II from either perhaps researchers could find out if aspirin with ibuprofen together retains longevizing functionality as the enzyme system noted at the yahoo article is 

 

The presence of i buprofen seems to disrupt the enzyme Tat2 permease, which helps a cell take in that oh-so-necessary tryptophan. However, lifespan for the yeast still saw a significant jump even when that enzyme was deactivated. (In these conditions, tryptophan levels were reduced but not to zero, since the yeast cell can make tryptophan internally.)

Furthermore, when the scientists stabilized the enzyme activity while exposing the yeast to ibuprofen, the yeast’s lifespan did not increase — meaning the ibuprofen was doing something else to boost the cell health when the tryptophan wasn’t. 

Deactivating the permease, which rapidly takes in amino acids like tryptophan, has an unexpected effect on cell aging. “Ibuprofen slows the transport of amino acids, and the protein synthesis slows down,”   Kennedy tells Yahoo Health. Slower protein synthesis equals slower aging — which equates to increased longevity across all the species. After yeast, the same bump was shown in fruit flies and worms.
This study is the first to identify a potential new drug candidate to target aging: ibuprofen. According to Kennedy, if the drug had the same effect in humans, something that needs to be tested, it could mean a significant enhancement of healthy aging.
 
 
Also at least one researcher has noted that ibuprofen has similarities to SPF 2.4
 
 
 
 
Arch Dermatol Res. 1982;272(3-4):263-7.
Reduction of the erythema response to ultraviolet light by nonsteroidal antiinflammatory agents.
Abstract

The effect of three nonsteroidal antiinflammatory agents (NSAIA) on ultraviolet B (UV-B)-induced erythema was studied in normal human volunteers. Aspirin, indomethacin, and ibuprofen were administered orally 2 h before exposure to UV-B from fluorescent sunlamps and at 4-h intervals for a total of four doses. The minimal dose of light to produce erythema (MED) was determined for each subject with and without drugs. There was a 240% increase in the mean MED when the NSAIA were given. NSAIA, given orally, can increase the threshold for UV-B-induced erythema when administered near the time of irradiation.

PMID: 7165335  

 


Edited by treonsverdery, 05 January 2015 - 09:07 PM.

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#8 eon

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Posted 01 June 2015 - 01:02 AM

Anti-Inflammatory Drugs May Help Treat Depression

 

http://mentalhealthd...eat-depression/



#9 nowayout

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Posted 01 June 2015 - 01:48 PM

 

 

I'm not sure what you're getting at but corticosteroids have serious side effects. As with anything they are dose dependent. But as for steroids, it heals you up faster than NSAID. I've never seen a steroid retailer sell corticosteroids. Seems like it has different actions than steroids and NSAIDs.

 

 

You are confusing Corticosteroids which are used as anti-inflammatories with Anabolic Steroids which are used for muscle bulking

 

 

Your really don't understand what I was getting at? In your original post you suggested using anabolic steroids as an anti-inflammatory. Bulking steroids, aka anabolic steroids are not anti-inflammatory.

 

Google and Pubmed actually bring up a number of studies showing testosterone to be anti-inflammatory at physiological doses (in hypogonadism), so the OP isn't entirely wrong.  Of course this doesn't necessarily apply to other anabolics nor necessarily to supraphysiological doses



#10 eon

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Posted 03 June 2015 - 11:44 AM

What are some good anti inflammatory that are not aspirin or ibuprofen or not NSAIDs? I'm leaning towards natural ones or something that can be taken regularly. I can think of vitamin C and lysine but are these enough? I'm starting to suspect that my belly fat (when sitting down) is a sign of inflammation. I'm only 150 pounds, standing up looks like in great shape, sitting down seems to be a problem, as if the belly fat just wouldn't go away regardless of how active I am and workout 6 days a week, even at one point I was 10 pounds light, the belly fat area would not go! Bellies should be flat! 


Edited by eon, 03 June 2015 - 11:47 AM.

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#11 fntms

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Posted 03 June 2015 - 12:58 PM

Ginkgo has some anti inflammation properties. Don't mix it with aspirin or ibuprofen though.
I have been taking the 'strong' ginkgo extract (120mg) for a while and it seems to have helped with joint pain (where the usual nsaids did little).

#12 eon

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Posted 04 June 2015 - 10:20 AM

It shouldn't be mixed with an amphetamine either. Not sure why. I saw it listed as having moderate interaction with Vyvanse. Is gingko a stimulant, is that why? What do you think of omega-3s as anti inflammatory?

 

Ginkgo has some anti inflammation properties. Don't mix it with aspirin or ibuprofen though.
I have been taking the 'strong' ginkgo extract (120mg) for a while and it seems to have helped with joint pain (where the usual nsaids did little).

 


Edited by eon, 04 June 2015 - 10:21 AM.


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#13 treonsverdery

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Posted 19 August 2015 - 07:52 PM

I support longevity research.  This is a list of chemical modifications that cause mammals to live longer http://io9.com/do-th...an-co-486041314

 

Also the Ames mouse is genetically engineered to live longer.  It is possible that people could go on medical tourism cruises to be outside of legal jurisdictions so they could get longevity gene therapy that doubles their lifespan or longer. 

 

here is an image of the quantitatively measured longevity effect of a genetic modification

Attached File  Figure1.jpg   137.26KB   3 downloads

 


Edited by treonsverdery, 19 August 2015 - 07:53 PM.






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