6 replies to this topic

[zen]

Just a quote from the ScienceDaily article, full text here http://www.scienceda...60203145723.htm

 

"The advantage of targeting senescent cells is that clearance of just 60-70 percent can have significant therapeutic effects," says Dr. Baker. "If translatable, because senescent cells do not proliferate rapidly, a drug could efficiently and quickly eliminate enough of them to have profound impacts on healthspan and lifespan."

 

[nowayout]

Wasn't this discussed here a year or so ago already (see the long threads on senolytics), or is it a new study?

Edited by nowayout, 06 February 2016 - 03:19 PM.

[zen]

Wasn't this discussed here a year or so ago already (see the long threads on senolytics), or is it a new study?

​It is a new study poblished on February 3rd, 2016 - http://www.nature.co...ature16932.html

[zen]

Here is a link to the related video -

[turboblufer]

Is there any kaplan-meier pictures available in good quality? 

Edited by turboblufer, 06 February 2016 - 04:08 PM.

[stefan_001]

Mayo Clinic researchers used a transgene that allowed for the drug-induced elimination of senescent cells from normal mice. Upon administration of a compound called AP20187, removal of senescent cells delayed the formation of tumors and reduced age-related deterioration of several organs. Median lifespan of treated mice was extended by 17 to 35 percent. They also demonstrated a healthier appearance and a reduced amount of inflammation in fat, muscle and kidney tissue.

[nowayout]

From what I can glean from the non-paywalled information available, this intervention increases median lifespan, not maximum lifespan. So the death bottleneck isn't delayed, unlike the CR studies.

 

What does the death bottleneck consist of?  What is it that makes these healthier treated mice still suddenly keel over dead (presumably) at the same maximum age?