34 replies to this topic

[QuestforLife]

I didn't say its never been discussed in the past, I said this tec was about the only thing that makes such a dramatic age reversal and belongs in this thread. Changing epigenetic markers should produce health benefits but if you can actually rewind it to a younger state, then by definition you have reversed age

Your words were why has no one mentioned this tech...when it is obvious people on this site are more than well aware of epigenetic reprogramming.

You are also incorrect that 'by definition' if you rewind epigenetic markers you have reversed age. It is completely possible for epigenetic markers to very closely track chronological age, but when you find interventions that dramatically rewind the markers, you do no necessarily rewind the underlying age. At this point we don't know if these clocks become useless once interventions decouple them from chronological age. Hence my comment about awaiting actual robust lifespan extension from the plasma fractions treatments that rewind epigenetic age. My guess is that epigenetic age reversal is to do with the percentages of different cell types in the blood (and saliva, etc.,) and as such does have real benefits, but they may only be transitory. We shall see.

[adamh]

You say I'm incorrect according to your opinion. There are many, not just myself, who think reverting cells back to a younger state does in fact make the organism younger. You say no but admit you don't know yourself.

 

David Sinclair wrote:

"Our bodies hold a backup copy of our youth that can be triggered to regenerate, said Sinclair, the senior author of a new paper showcasing the work of his lab and international scientists."

 

https://www.cnn.com/...ness/index.html

 

I think he knows a little bit more about the subject that we do and he said that. I agree that the tec is not quite ready yet and we need to watch and see how animals which were made "younger" age and see if they age normally afterward and also to see if the treatment can be given multiple times.

 

There are animals now that seem to be immortal. They revert to a stage at the early part of life and then age normally. Some can do this many times, perhaps forever. Its not the only path to immortality but I think its a mistake to ignore it because some think it won't work

 

https://english.elpa...ernal-life.html

[QuestforLife]

You say I'm incorrect according to your opinion. There are many, not just myself, who think reverting cells back to a younger state does in fact make the organism younger. You say no but admit you don't...
David Sinclair wrote:

I am specifically talking about whether reverting some methylation markers (various epigenetic clocks) in some cells in a bodyback to a value associated with youth actually reverts the whole body back to youth. That is a tall order. I do not say there is nothing in this line of research. But I've read many papers on the subject and you are giving me press releases by the salesman David Sinclair.

[Aeon]

Interesting thread about a topic I think of quite often, so I will give a bit of my thoughts about it.

 

In term of resources invested in the field, it's clear that the total amount is meager for someone who sees rejuvenation, curing aging and 'extreme life extension' as things that were hopefully a main goal for humanity nowadays. Yes, I know there has been a considerable increase in financial investment in the field in the last decade or so, but if I take the end goal to make curing aging and a large and fundamentally unrestricted life extension possible for as many people alive today as possible- it most likely greatly falls short of it. And of course, it's not just monetary investment. There needs to be a lot of organized research directed at the field.

 

Perhaps, if human society today operated differently and actually took it as a main objective that different nations collaborated with each other in an international effort, to research the causes/damages of aging with the aim of repairing them, all this in an organized manner involving the top research institutions in the world, this could have moved things a lot more effectively. Also- biotech industries could be highly supported by nations and international organizations to participate in the effort. You can envision something that holds some similarities to the international efforts in 2020 and the years that followed for the research on the coronavirus.

 

Also, keep in mind it is not an exact science field where you could calculate equations to discover cures. You have to make experiments in living bodies- and this takes time, years.

This all makes an organized, international and hopefully highly funded effort even more crucial in my opinion for a realistic chance to achieve extreme longevity and curing aging (today often referred to as achieving 'longevity escape velocity') in our lifetime.

 

When the world powers wanted to get to the moon and land a person there, they knew how to dedicate their resources and abilities for that matter. And isn't curing aging and rejuvenation not less important, or urgent? I dare to say it's even more.

 

[南尧说生]

The following machine translation is relied upon for poor English proficiency.

I think you can take a look at my theory. The biggest problem with the current slow pace of aging research is the lack of a systematic perspective. However, my current hypothesis has such a systematic perspective, and the description of the self-locking mechanism can explain why current anti-aging approaches have failed but are still correct.

My theory proposes 80 non steady states, a steady-state metabolic state. On these 80 non steady state pathways, some people exhibit metabolic hyperactivity and oxidative stress, some show microcirculatory disorders and inflammatory factors that promote aging, some have insufficient antioxidant capacity and accumulate more aging cells, and some have decreased mitochondrial flash and epigenetic disorders.

The 80 non steady state can be said to cover most of the characteristics of aging theory, but I am not elaborating on these characteristics. Instead, I point out that the aging characteristics of these pathways will all belong to one, leading to a decrease in mitochondrial functionality and triggering the next aging factor, glucose and lipid metabolism disorder, which in turn will lead to a decrease in growth hormone levels.

The initial factor that drives the decline of mitochondrial function in aging is very weak. At the end of puberty, it can be masked by vigorous growth hormone, and when it truly exerts its power, it is at the end of puberty when growth hormone levels decrease. At this time, it will drive the decline of mitochondrial function, which in turn leads to the disorder of glucose and lipid metabolism, which in turn drives the decline of growth hormone. The decline of growth hormone is the most intense factor driving the early stages of aging in this theory, but it is not the focus, but it will also promote the operation of downstream aging mechanisms.

The whole process is like a biological vacuum decay, with the endpoint being 105 years old. The risk of aging and death is no longer increasing, but in fact, all bodily functions that sustain life are in the worst working condition and cannot collapse further. Therefore, the risk of death caused by death is no longer increasing.

And the self-locking mechanism I am referring to in this theory is why intervening in a single pathway is not effective in anti-aging, because the body has entered a suboptimal steady state with self strengthening and self-sustaining functions. For example, when growth hormone decreases, NRF1 expression will decrease, and the quantity and quality of mitochondria will decrease. Growth hormone is secreted in a pulsatile manner, and it relies heavily on ATP pulsatile bursts. As a result, a vicious cycle of self strengthening and self maintenance emerges. Such mechanisms exist in multiple ways during the aging process, covering the current traditional aging theory, which leads to a single intervention pathway having very poor effectiveness.

Edited by 南尧说生, 05 November 2025 - 06:57 PM.