Lifespan of mice extended by as much as 35 percent using AP20187 to remove senescent cells
#1
Posted 06 February 2016 - 02:55 PM
#2
Posted 06 February 2016 - 03:19 PM
Wasn't this discussed here a year or so ago already (see the long threads on senolytics), or is it a new study?
Edited by nowayout, 06 February 2016 - 03:19 PM.
#3
Posted 06 February 2016 - 03:26 PM
Wasn't this discussed here a year or so ago already (see the long threads on senolytics), or is it a new study?
It is a new study poblished on February 3rd, 2016 - http://www.nature.co...ature16932.html
#4
Posted 06 February 2016 - 03:32 PM
Here is a link to the related video -
#5
Posted 06 February 2016 - 04:07 PM
Is there any kaplan-meier pictures available in good quality?
Edited by turboblufer, 06 February 2016 - 04:08 PM.
#6
Posted 06 February 2016 - 06:40 PM
Mayo Clinic researchers used a transgene that allowed for the drug-induced elimination of senescent cells from normal mice. Upon administration of a compound called AP20187, removal of senescent cells delayed the formation of tumors and reduced age-related deterioration of several organs. Median lifespan of treated mice was extended by 17 to 35 percent. They also demonstrated a healthier appearance and a reduced amount of inflammation in fat, muscle and kidney tissue.
#7
Posted 07 February 2016 - 03:04 PM
From what I can glean from the non-paywalled information available, this intervention increases median lifespan, not maximum lifespan. So the death bottleneck isn't delayed, unlike the CR studies.
What does the death bottleneck consist of? What is it that makes these healthier treated mice still suddenly keel over dead (presumably) at the same maximum age?
Also tagged with one or more of these keywords: senescent cells, life extension
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