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Does it upregulate or downregulate GABA(A) receptors over time? I've seen user experiences citing sedative-like properties, which makes me wonder whether it's actually a GABA agonist.
What are your experiences with this?
What's the verdict on Bacopa's GABA effects?
Started by
Picard
, Dec 27 2012 11:03 PM
7 replies to this topic
#4
Posted 28 December 2012 - 10:01 AM
Reading the abstract of the study people were citing for its upregulation of GABA receptors, I'm not at all convinced that it does this when its use isn't actively preventing seizures experienced by an epileptic control group.
I haven't seen anything on it being a GABAergic either, though. Other, better established MoA explain its sedative properties well enough. I agree with nupi that if it is, it probably isn't a strong enough one to cause downregulation.
So as far as I'm ware, neither.
I haven't seen anything on it being a GABAergic either, though. Other, better established MoA explain its sedative properties well enough. I agree with nupi that if it is, it probably isn't a strong enough one to cause downregulation.
So as far as I'm ware, neither.
Edited by Raza, 28 December 2012 - 10:02 AM.
#5
Posted 28 December 2012 - 06:04 PM
It's my understanding that 5-HT1a agonism (and possibly 5-HT release) is primarily responsible for the effects, so I wouldn't think GABA should be dramatically up- or down-regulated. I have seen the study that raza refers to suggesting GABA upregulation.
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