Uridine and Dopamine

#1 Kewell357

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Posted 27 August 2014 - 11:37 PM

Can Uridine decrease amphetamine tolerance if taken together?

It is said to upregulate dopamine receptors. And if so, by that logic, then can Phenylpiracetam and CDP Choline do the same?

#2 Omega 3 Snake Oil

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NO

Posted 28 August 2016 - 06:56 PM

I'd like to know about this as well. I have high dopamine (took selegiline under rx for years) and am wondering if it's safe to try uridine.

#3 vader

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Posted 28 August 2016 - 08:08 PM

I feel absolutely nothing from increasing uridine levels...

like x 1

#4 gamesguru

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Posted 28 August 2016 - 08:28 PM

No. Uridine promotes a "potassium-evoked dopamine release," a primarily presynaptic mechanism. It works by downregulating autoreceptor activity (presynaptic receptors which reduce and modulate NT release). But in the case of amphetamine abuse, a gross downregulation is already the status quo on both the presynaptic and postsynaptic sites. That's why we actually see better results from glutamate (memantine) or dopamine antagonists

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#1 Kewell357

#2 Omega 3 Snake Oil

#3 vader

#4 gamesguru

Also tagged with one or more of these keywords: uridine, cdp choline

My nootropics stack for focus and memory

Uridine monophosphate supplier for Ikg

Uridine: sublingual form and B vitamins

Uridine (mrhappystack) + Adderall (small amount) - will it at least mitigate further damage?

Uridine- dangers?

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