Do you look YOUNGER ?

I have been taking an extract of Japanese Knotweed Root that i purchase from a supplier of Chinese herbs. I went this route to lower my costs. Of course along with this comes a whole host of other substances. I have been taking this for about 1.5 years. I put it in capsules for convenience. I would like to state that I have no affiliation with anyone who makes/ markets resveratrol. There seems to be a bit of discord in the forum in that area.

Okay now for the juicy anecdotal evidence. First I am not a chemist. So treat me as the layman I am. I am a 56 year old male. High chlorestral runs in the family. My father died at age 63 due to complications of the circulatory system. My mother died of ovarian cancer at age 67. I tell people I am saving for my wife's retirement. I started by taking 6 00 capsules of the substance spaced out throughout the day. During the first two weeks I lost 14 lbs which brought my weight down to 160 lbs. The most obvious aspect of this is that this was mostly from the abdomen. I also noticed an increase in energy starting at approx. 30 minutes after ingestion. I had a grey beard. But it has slowly going dark again. All the new hairs are dark. The grey has remained grey. I also have male pattern baldness. Previously I tried Rogaine. The results were moderate. Recently I started it again but this time, the increase in new hair is significant. People look at my last drivers license and want to know what I am doing. My bp and chlorestral levels also went down. It should be noted that I drink about a pint of green tea a day (brewed for 6 minutes to increase quecetin levels, along with substantial amounts of b vitamins taken simultaneously. i also drink one cup of pomegranate juice a day. I do not know how much these things might affect my response. A friend of mine who has diabetes (he also takes a large number of pills due to being a liver transplant recipient. He also has Hep C with a zero virus load due to the pills he takes. ) He takes about three of these pills a day. His insulin resistance has improved by 50 pts. In addition he reports that the partial numbness in his feet that had been increasing, seems to have reversed. So something is going on.

After a lapse of several years I had my blood tested as part of a physical. My chlorestral was improved, my liver enzymes, which were a little elevated were normal.

I now take four/five (alternating) capsules a day. when i take 6 capsules I experience a tightening of the archiles tendon. I backed off the number of capsules, then built it back up till the symptoms reoccurred, and came up with the current regime.

So yes, I look a bit younger, but I have a feeling that I am going to need something more effective, since my acid test is the number of women in their 20's who hit up on me. Since I do not allow blind women who have no powers of discrimination to partake in the test, the results in that area have been very disappointing!

Thanks for sharing. Motivating.

Edited by eugenius, 17 March 2009 - 11:49 PM.

It would make more sense to me that if Resveratrol did anything-- the best it could do would be to slow the damaging effects of aging-- not reverse damage that has been done. If it allowed for you to reduce hunger pains, or exercise more-- those effects would be the contributing factors keeping you looking and feeling better. Because Resveratrol turns on genes for maintenance and repair-- I would assume it might even be determental to top athletes who are looking to maximize growth and performace.

Resveratrol inhibits NF Kappa B http://www.jimmunol....act/164/12/6509 and there was a study in 2007 showing that by block NF kappa B you get a rejuvenation effect on the skin; http://www.newscient...thful-glow.html

"Blocking the effects of a single gene can reverse skin ageing in mice, reveals a new study. Geriatric two-year-old mice with thinned, ageing skin treated by researchers temporarily reverted to having more youthful skin"

"the experimental treatment patch had produced about a 75% increase in the thickness of the skin."

Edited by Matt, 18 March 2009 - 09:45 PM.

BTW: a jumping out of the skin sensation (restlessness?) with Longevinex is likely due to the other factors in that product, like IP6. Resveratrol should not cause such effects as far as I know.

Both my friend and I seem to have experienced the same jumping out of the skin sensation with Longevinex right at the one week mark. I was taking 400mg+ and he was just taking 100mg although 20% lighter than me. I wouldn't call it restlesseness, but a senation of not getting quite enough oxygen in the face and arms. That lasted a few hours at night, a few hours the next morning and then never again. He laughed and said it was like an anxiety attack he'd get before a college exam. But two others had both no reaction, and a reaction that seemed similar to mine right away, so he stopped. I have read that all resveratrol may have numerous mild side efects, especially toward 500mg. I'd say what I experienced was distinct but mild. No headache , nausea or pain.

When I was taking 400 to 500 mg a day at 37 years old, I noticed a clear 10% weight loss over two weeks and increased endurance while biking up tough hills. My skin is also clearly smoother. Could that be from something else? I'm pretty sure I have hair gain based on a before and after pic, but not positive.

Now here is something that seems odd to me. For a couple of reasons including being curious, I have put on not just the 10% I lost (that came back up yet I reduced to 200mg/day) but ate a lot of fatty foods, drank beer, coke, all the things a doctor would shake his head at for about 6 months. Now I'm 15% over my once very steady weight, yet even reducing to 100mg/day I can ride up that steep hill despite having a bigger gut and greatly reduced running and biking. (I use a bike to get around so usually a minimum of 60 minutes a day on days I say I dont excercise)

This is obviously not a well controlled study even on one data point (me), and I should have stayed at 300mg to 400mg for a better indicator. That very large and long hill is harder now than a year ago, but as a friend I went up it with yelled back: "I can't believe you aren't having any trouble on this hill, and you've been talking the whole time!" That was true, and I explained that I'd even gained quite a bit of weight yet it wasn't so tough.

I also have not been sick once since starting resveratrol (Longy) and colds are very mild with no coughing. I used to get something pretty bad for 2 weeks in late fall and/or 2 weeks in late winter. That might be coincidence, but sure is odd.

BTW: a jumping out of the skin sensation (restlessness?) with Longevinex is likely due to the other factors in that product, like IP6. Resveratrol should not cause such effects as far as I know.

Both my friend and I seem to have experienced the same jumping out of the skin sensation with Longevinex right at the one week mark. I was taking 400mg+ and he was just taking 100mg although 20% lighter than me. I wouldn't call it restlesseness, but a senation of not getting quite enough oxygen in the face and arms. That lasted a few hours at night, a few hours the next morning and then never again. He laughed and said it was like an anxiety attack he'd get before a college exam. But two others had both no reaction, and a reaction that seemed similar to mine right away, so he stopped. I have read that all resveratrol may have numerous mild side efects, especially toward 500mg. I'd say what I experienced was distinct but mild. No headache , nausea or pain.

When I was taking 400 to 500 mg a day at 37 years old, I noticed a clear 10% weight loss over two weeks and increased endurance while biking up tough hills. My skin is also clearly smoother. Could that be from something else? I'm pretty sure I have hair gain based on a before and after pic, but not positive.

Now here is something that seems odd to me. For a couple of reasons including being curious, I have put on not just the 10% I lost (that came back up yet I reduced to 200mg/day) but ate a lot of fatty foods, drank beer, coke, all the things a doctor would shake his head at for about 6 months. Now I'm 15% over my once very steady weight, yet even reducing to 100mg/day I can ride up that steep hill despite having a bigger gut and greatly reduced running and biking. (I use a bike to get around so usually a minimum of 60 minutes a day on days I say I dont excercise)

This is obviously not a well controlled study even on one data point (me), and I should have stayed at 300mg to 400mg for a better indicator. That very large and long hill is harder now than a year ago, but as a friend I went up it with yelled back: "I can't believe you aren't having any trouble on this hill, and you've been talking the whole time!" That was true, and I explained that I'd even gained quite a bit of weight yet it wasn't so tough.

I also have not been sick once since starting resveratrol (Longy) and colds are very mild with no coughing. I used to get something pretty bad for 2 weeks in late fall and/or 2 weeks in late winter. That might be coincidence, but sure is odd.

All of longiv____'s psychological effects (energy, anxiety etc.) are attributable to quercetin, which is a COMT inhibitor (inhibits the enzyme that breaks down catecholamines - dopamine, norepinephrine, epinephrine)^{1, 2} and an adenosine receptor antagonist^3,4 like caffeine. It also has immunomodulatory properties^5,6 and anti-obesity effects^7,8,9 so it appears to account for your experience with longy.

Quercetin is really inexpensive!

Happy aging,
VG


1.Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition.http://www.ncbi.nlm.nih.gov/pubmed/12711835

2.CYP1A1/CYP1B1- and COMT-Derived Metabolites Mediate Estradiol-Induced Antimitogenesis in Human Cardiac Fibroblast http://jcem.endojour...c.2003-032154v1

3. No effect of nutritional adenosine receptor antagonists on exercise performance in the heat
http://ajpregu.physi...ct/90812.2008v1

4. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance.http://www.ncbi.nlm.nih.gov/pubmed/19211721?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportP
anel.Pubmed_RVDocSum

5. Quercetin reduces susceptibility to influenza infection following stressful exercise
http://ajpregu.physi...ct/90319.2008v1

6. Dietary quercetin, immune functions and colonic carcinogenesis in rats.
http://grande.nal.us...p;therow=386035

7. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
http://www.sciencedi...adb0e601261a9e2

8. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin.
http://www.ncbi.nlm....pubmed/18433793

9. Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes.
http://www.cababstra...cNo=20053055348

Resveratrol inhibits NF Kappa B http://www.jimmunol....act/164/12/6509 and there was a study in 2007 showing that by block NF kappa B you get a rejuvenation effect on the skin; http://www.newscient...thful-glow.html

"Blocking the effects of a single gene can reverse skin ageing in mice, reveals a new study. Geriatric two-year-old mice with thinned, ageing skin treated by researchers temporarily reverted to having more youthful skin"

"the experimental treatment patch had produced about a 75% increase in the thickness of the skin."

The resveratrol skin cream I'm using is having just such an effect for me and my spouse. Facial skin seems thicker. Deep creases remain, but the fine wrinkles are disappearing. My acne rosacea is better controlled than with metrogel: one mild flare-up in a year, versus monthly.

Possible but very doubtful. I think the best we can hope for from resveratrol is slowing down the aging process, not reversing it.

With that said, people do typically tell me I look 8 years younger than I am (I'm 40). But I attribute this primarily to my daily exercise regimen (intense resistance and cardio training), consistent adequate sleep, limited stress, ensuring I don't burn when I'm out in the sun, and not smoking etc. To a lesser extent, my extensive supplement regimen, use of facial creams, and keeping my head shaved (since we're talking about appearances) should also help. I do take 1.5 grams 99% powered res twice a day in a liquid suspension.

All of longiv____'s psychological effects (energy, anxiety etc.) are attributable to quercetin, which is a COMT inhibitor (inhibits the enzyme that breaks down catecholamines - dopamine, norepinephrine, epinephrine)^{1, 2} and an adenosine receptor antagonist^3,4 like caffeine. It also has immunomodulatory properties^5,6 and anti-obesity effects^7,8,9 so it appears to account for your experience with longy.

Thanks for the links. Why would quercetin give me an effect on about the 7th day for just three hours at night, four hours the next day, and then not again for 18 months? I also don't consider the energy effect psychological even if I can't prove that.

I don't know much about resveratrol or quercetin, but it seems as if you are saying resveratrol likely does nothing for endurance (I think that is a better discription in my case than energy). At the same time, one mouse study showed a mouse loaded with resveratrol had endurance twice as great as the mouse without. I take much less and definately dont feel like the super mouse, but something seems to have happened. It felt like the difference I felt going from average endurance to good endurance prior to longevinex. Then longevinex seemed to give me a further training gain.

I wonder when we'll know if the extra endurance was a placebo effect. If so, it is a very good one.

Resveratrol inhibits NF Kappa B http://www.jimmunol....act/164/12/6509 and there was a study in 2007 showing that by block NF kappa B you get a rejuvenation effect on the skin; http://www.newscient...thful-glow.html

"Blocking the effects of a single gene can reverse skin ageing in mice, reveals a new study. Geriatric two-year-old mice with thinned, ageing skin treated by researchers temporarily reverted to having more youthful skin"

"the experimental treatment patch had produced about a 75% increase in the thickness of the skin."

So REsveratrol does make you look younger. I am trying to reverse my age about 20 years or so. That would be just right. Anyhow, there is a major kink in the plans. I have to hold the Resveratrol due to back and knee problems for a while. My back is getting better but can't tell if it is cause i stopped the drug. Real test will be when i start it back up again and see if the knee and back issues come back or not.

Resveratrol inhibits NF Kappa B http://www.jimmunol....act/164/12/6509 and there was a study in 2007 showing that by block NF kappa B you get a rejuvenation effect on the skin; http://www.newscient...thful-glow.html

"Blocking the effects of a single gene can reverse skin ageing in mice, reveals a new study. Geriatric two-year-old mice with thinned, ageing skin treated by researchers temporarily reverted to having more youthful skin"

"the experimental treatment patch had produced about a 75% increase in the thickness of the skin."

So REsveratrol does make you look younger. I am trying to reverse my age about 20 years or so. That would be just right. Anyhow, there is a major kink in the plans. I have to hold the Resveratrol due to back and knee problems for a while. My back is getting better but can't tell if it is cause i stopped the drug. Real test will be when i start it back up again and see if the knee and back issues come back or not.

Back issues can be due to arthritis, muscle or tendon strain, or stenosis from arthritic changes, in the facet joints. or the nerve roots. It is conceivable the same mechanism causing join pain in elbows, fingers or knees with resveratrol use could be affecting the back, or it may be coincidental.

I don't think topical resveratrol will cause joint pain.

I agree with your comments about the various reasons why these physical glitches occur, but,Im sure there is a correlation between dosage and tendon pain, as a minor side, a side effect that seems to lessen over a period of regular oral ingestion. I used a transdermal Resveratrol that didnt give that side effect, but it also did not provide the level of an energy boost or weight loss as the oral and transdermal combined in modest amounts.

Edited by 2tender, 20 March 2009 - 12:34 PM.

Resveratrol inhibits NF Kappa B http://www.jimmunol....act/164/12/6509 and there was a study in 2007 showing that by block NF kappa B you get a rejuvenation effect on the skin; http://www.newscient...thful-glow.html

"Blocking the effects of a single gene can reverse skin ageing in mice, reveals a new study. Geriatric two-year-old mice with thinned, ageing skin treated by researchers temporarily reverted to having more youthful skin"

"the experimental treatment patch had produced about a 75% increase in the thickness of the skin."

So resveratrol does make you look younger.

No, it does not follow. Such a conclusion is at best highly speculative. For starters, no resveratrol was involved in the mouse study.

Edited by andre, 20 March 2009 - 01:43 PM.

Resveratrol has well-established blood sugar normalizing abilities, right? Is that a possible answer for the people who appear slightly younger or healthier within days of starting res? Is there a connection between high blood sugar and poor skin appearance?

edit: double post

Edited by VespeneGas, 20 March 2009 - 06:45 PM.

Thanks for the links. Why would quercetin give me an effect on about the 7th day for just three hours at night, four hours the next day, and then not again for 18 months? I also don't consider the energy effect psychological even if I can't prove that.

I don't know much about resveratrol or quercetin, but it seems as if you are saying resveratrol likely does nothing for endurance (I think that is a better discription in my case than energy). At the same time, one mouse study showed a mouse loaded with resveratrol had endurance twice as great as the mouse without. I take much less and definately dont feel like the super mouse, but something seems to have happened. It felt like the difference I felt going from average endurance to good endurance prior to longevinex. Then longevinex seemed to give me a further training gain.

I wonder when we'll know if the extra endurance was a placebo effect. If so, it is a very good one.

This is the abstract to the fourth study I posted, which should help demonstrate that quercetin not only boosts mental energy through it's affect on catecholamines, but also physical energy through it's effect on mitochondrial biogenesis. This is consistent with the greater exercise endurance you experienced.

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance.
Davis JM, Murphy EA, Carmichael MD, Davis B. University of South Carolina.

Quercetin is one of a broad group of natural polyphenolic flavonoid substances that are being investigated for their widespread health benefits. These benefits have generally been ascribed to its combination of anti-oxidant and anti-inflammatory activity, but recent in vitro evidence suggests that improved mitochondrial biogenesis could play an important role. However, the in vivo effects of quercetin on mitochondrial biogenesis exercise tolerance are unknown. We examined the effects of 7-days of quercetin feedings in mice on markers of mitochondrial biogenesis in skeletal muscle and brain, and on endurance exercise tolerance. Mice were randomly assigned to one of three treatment groups: placebo, quercetin 12.5mg/Kg, or quercetin 25mg/Kg. Following 7 days of treatment mice were sacrificed and soleus muscle and brain were analyzed for mRNA expression of PGC-1alpha and SIRT1, and mtDNA and cytochrome c. Additional mice underwent a treadmill performance run to fatigue or were placed in voluntary activity wheel-cages and their voluntary activity (distance, time & peakspeed) was recorded. Quercetin increased mRNA expression of PGC-1alpha and SIRT1 (P<0.05), mtDNA (P<0.05) and cytochrome c concentration (P<0.05). These changes in mitochondrial capacity were associated with an increase in both maximal endurance capacity (P<0.05) and voluntary wheel running activity (P<0.05). These benefits of querectin on fitness without exercise training may have important implications for enhancement of athletic and military performance and may also extend to prevention and/or treatment of chronic diseases. Key words: flavonoid, endurance capacity, mitochondria.

PMID: 19211721

Resveratrol has similar favorable effects in lab mice wrt mitochondria. The primary difference between quercetin and resveratrol (in Longivenex) is that the former is dosed high enough to produce an effect, whereas the latter is not.

Resveratrol has similar favorable effects in lab mice wrt mitochondria. The primary difference between quercetin and resveratrol (in Longivenex) is that the former is dosed high enough to produce an effect, whereas the latter is not.

I must have skipped that one. I like the endurance gain, but I started taking resveratrol for possible anti cancer and anti heart disease potential. Since quercitin is cheaper, are you avoiding resveratrol for now? If you are taking one or both, how much do you take a day?

The U Wisconsin researcher who was on the January 60 Minutes show states on a Longevinex ad (on google video) that he thinks there is a likely synergistic effect between the qercetin, resverartrol and IP6 but didnt elaborate. Any thoughts on that?
To my knowledge, Sinclair never said anything on TV about taking Longy, just that he and half his lab were taking resv. This U Wisconsin guy is the first Ive heard to specifically say something about Longy.

I must have skipped that one. I like the endurance gain, but I started taking resveratrol for possible anti cancer and anti heart disease potential. Since quercitin is cheaper, are you avoiding resveratrol for now? If you are taking one or both, how much do you take a day?

I take 400 mg quercetin every day, for a number of reasons (it also stabilizes mast cells, which helps with allergies). Resveratrol probably has unique benefits (even though quercetin activates SIRT1 in vivo and appears to share resveratrol's anti-tumor qualities) but it's a little too expensive for me to take it every day. I take 500-1000mg resveratrol with quercetin on fasting days to help provoke autophagy and SIRT1 activation. Quercetin and resveratrol do appear to synergise, because quercetin inhibits CYP3A4 and CYP2C9 and prevents resveratrol from being glucorinidated and sulfated (actually, it may only prevent one of the two processes... ask geddarkstorm ). Anecdotally (and in agreement with scaling from the mouse studies) people need about 500mg/day of resv to achieve benefits. If you've got cash on hand, I personally recommend getting a high-purity resveratrol product and dosing ~500mg/day with ~500mg quercetin.

The U Wisconsin researcher who was on the January 60 Minutes show states on a Longevinex ad (on google video) that he thinks there is a likely synergistic effect between the qercetin, resverartrol and IP6 but didnt elaborate. Any thoughts on that?

Now that I look more closely at Longevinex's product, there isn't enough of any ingredient to have much of an effect, unless you took about 5 pills at a time. Though on principle I would avoid taking IP6 with food as it is an antinutrient that prevents absorbtion of minerals. Vitamin D is extremely cheap and highly recommended, most people are insufficient

Don't get tricked by inflated prices and dishonest advertising!

Sorry for hijacking the thread!

Now that I look more closely at Longevinex's product, there isn't enough of any ingredient to have much of an effect, unless you took about 5 pills at a time. Though on principle I would avoid taking IP6 with food as it is an antinutrient that prevents absorbtion of minerals. Vitamin D is extremely cheap and highly recommended, most people are insufficient

Don't get tricked by inflated prices and dishonest advertising!

Thanks again. I don't think I'm being fooled by claims. The problem is that we know Sinclair took 320mg (160mg/160mg) with food at his weight. We also know another major researcher the U Wisconsin researcher discussed Longevinex and said positive things about its likely synergistic effects. That doesn't mean others don't work as well, and I don't think there is anything magical about that brand. But.... I'm a little dissapointed that in 2009 other researchers aren't making public statements about other brands or saying 'these five are very similar' etc. I don't know if tween is better than ,er, non-tween. This is why I appreciate these comments.

Most posting understand more than I do, so I see why they think some of us are naive about the benefits of a particular brand.

There are some really smart and experienced people here. This is a great place to learn even though this forum isnt as active as I would like. The bottom line for people is to make their own decisions based on info and their own subjective experiences with a particular product. I know what products agree with my physiology and those are the ones I use. We find out what works by using them. A general rule of thumb right now IMO is to use micronized 99% pure Resveratrol at approx 250-500 milligrams, that has been echoed elsewhere. Consistent use is probably more important than dosage IMO.

I have only been taking Resvaratrol for about 6 weeks now. but now i have couple of people telling me that i look younger. They have no idea i am taking this medication. Has this happen to you ? and does younger girls think you are younger than you really are ?

actually resv will make you look a little older and if done right it will make your joints hurt

I have only been taking Resvaratrol for about 6 weeks now. but now i have couple of people telling me that i look younger. They have no idea i am taking this medication. Has this happen to you ? and does younger girls think you are younger than you really are ?

actually resv will make you look a little older and if done right it will make your joints hurt

Was that your experience?

I will be 55 and have been taking RES for 3 years and I do think I look younger, stronger, and feel healthier.

Wish I could have started RES at age 20, 30 or 40

RES at 50s is better than no RES at 50s

Run on RES and look in the mirror everyday

Takes time to see the changes

Run on RES and look in the mirror everyday

Takes time to see the changes

The time issue is interesting. The scientist/basketball player who wrote that his arthritis was greatly reduced said that it took about 6 months, although he was using an anti arthritis pill as well before accidently forgeting, and just took resveratrol (I forget the brand, but not one I recognized).

I noticed an endurance boost one week after 500mg of Longevinex but didnt notice the smoother skin for about 6 months.

One other positive aspect is that after 18 months, I have had very minor colds but no sickness or nasty coughing that would normally last 2 weeks. I know there are those who don't get sick, but I always got sick in winter, often in late fall and always in late winter. Maybe this is luck, but I doubt it.

I think its safe to say there is a correlation with supplement ingestion and a lack of regular illness from colds etc. maybe even major illness. I think that most people using Res. are also using other supplements and exercise, CR etc. Is Resveratrol the only supplement you are taking?

I think its safe to say there is a correlation with supplement ingestion and a lack of regular illness from colds etc. maybe even major illness. I think that most people using Res. are also using other supplements and exercise, CR etc. Is Resveratrol the only supplement you are taking?

I'm only taking resveratrol (longy) but that reminds me that I should start omega 3 again. I really slacked off this winter excercising and gained weight but still just a couple of very mild colds. I'm in a place where it rains and snows a lot in winter, but I still ride about an hour just commuting. When I was taking 400mg/day, I was also running 5 days a week and biking over 2 hours many days. I have made it four seasons without getting sick (late fall and late winter....twice) When I got sick, I always had a horrible cough for over two weeks. Could be a coincidence.

There is vit. D and other things in longy, I wouldnt take as much as you do of that, as I would be concerned about vit. D toxicity. It could be a vitaminosis type thing. Maybe switching to a straight 99% pure micronized Res. or just stopping the longy would be in your best interest. Regular periods of no supplements is advantageous, 1-3 days off can help. If you experience the same after a break and resumation its probably the cause, sensitivities to fillers, excipients and the actual active itself are known to develop for some people.

There is vit. D and other things in longy, I wouldnt take as much as you do of that, as I would be concerned about vit. D toxicity. It could be a vitaminosis type thing. Maybe switching to a straight 99% pure micronized Res. or just stopping the longy would be in your best interest. Regular periods of no supplements is advantageous, 1-3 days off can help. If you experience the same after a break and resumation its probably the cause, sensitivities to fillers, excipients and the actual active itself are known to develop for some people.

I have take 100 to 200mg now. I took 400mg was when longy didn't contain vitamin D. I wouldn't be worried at all about D toxicity under 10,000 based on study summaries I've read , so that would be about 8 capsules per day.

There is vit. D and other things in longy, I wouldnt take as much as you do of that, as I would be concerned about vit. D toxicity. It could be a vitaminosis type thing. Maybe switching to a straight 99% pure micronized Res. or just stopping the longy would be in your best interest. Regular periods of no supplements is advantageous, 1-3 days off can help. If you experience the same after a break and resumation its probably the cause, sensitivities to fillers, excipients and the actual active itself are known to develop for some people.

I have take 100 to 200mg now. I took 400mg was when longy didn't contain vitamin D. I wouldn't be worried at all about D toxicity under 10,000 based on study summaries I've read , so that would be about 8 capsules per day.

I have read some Dr's who advise against taking more than 2000 units per day. That is the amount that I take. I suggest further research. No point in possibly hurting yourself. If you get a definitive answer then post it. I live in a northern state with a great number of overcast days and I have found taking vitamin D has improved my mood and added to a general sense of physical well being.

I have only been taking Resvaratrol for about 6 weeks now. but now i have couple of people telling me that i look younger. They have no idea i am taking this medication. Has this happen to you ? and does younger girls think you are younger than you really are ?

actually resv will make you look a little older and if done right it will make your joints hurt

Was that your experience?

yes but it seems to be the running theme of studies that i have read as well. i would advise taking resv but there are set backs. the joint pain comes from the fact that i am a power lifter by hobby and resv makes healing from injury or workouts longer.