Resveratrol stimulates cortisol biosynthesis 2012
Started by
fighter
, May 16 2013 02:37 AM
resveratrol glucocorticoid cortisol pubmed
1 reply to this topic
#1
Posted 16 May 2013 - 02:37 AM
Hello, I'm a little unsure and confused. Does this mean Resveratrol may consequently increase cortisol levels?
Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc.
http://www.ncbi.nlm....pubmed/22585829
In the human adrenal cortex, cortisol is synthesized from cholesterol by members of the cytochrome P450 superfamily and hydroxysteroid dehydrogenases. Both the first and last steps of cortisol biosynthesis occur in mitochondria. Based on our previous findings that activation of ACTH signaling changes the ratio of nicotinamide adenine dinucleotide (NAD) phosphate to reduced NAD phosphate in adrenocortical cells, we hypothesized that pyridine nucleotide metabolism may regulate the activity of the mitochondrial NAD(+)-dependent sirtuin (SIRT) deacetylases. We show that resveratrol increases the protein expression and half-life of P450 side chain cleavage enzyme (P450scc). The effects of resveratrol on P450scc protein levels and acetylation status are dependent on SIRT3 and SIRT5 expression. Stable overexpression of SIRT3 abrogates the cellular content of acetylated P450scc, concomitant with an increase in P450scc protein expression and cortisol secretion. Mutation of K148 and K149 to alanine stabilizes the expression of P450scc and results in a 1.5-fold increase in pregnenolone biosynthesis. Finally, resveratrol also increases the protein expression of P450 11β, another mitochondrial enzyme required for cortisol biosynthesis. Collectively, this study identifies a role for NAD(+)-dependent SIRT deacetylase activity in regulating the expression of mitochondrial steroidogenic P450.
#2
Posted 20 May 2013 - 10:49 PM
Does this mean resveratrol increases cortisol sysnthesis? In theory, it might. There have been some results demonstrating this in vitro, but that doesn't mean it happens in the live animal, where there are more feedback mechanism.
In one experiment on primates (lemurs,) it did not raise cortisol levels.
https://www.ncbi.nlm...pubmed/21304942
In one experiment on primates (lemurs,) it did not raise cortisol levels.
https://www.ncbi.nlm...pubmed/21304942
Also tagged with one or more of these keywords: resveratrol, glucocorticoid, cortisol, pubmed
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