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Question About GABA & CRH

gaba crh

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#1 farshad

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Posted 06 July 2018 - 05:58 PM


This study: https://www.ncbi.nlm...pubmed/10723009
''mRNAs for the alpha1 and beta2 subunits of the GABA(A) receptor were detected within 53.3% and 65.7% of PVN CRH neurons, respectively.''

Then this study: https://www.ncbi.nlm...pubmed/12480126
''Self-inhibition of GABA cannot stop all transport into the brain, and the highest recorded value of inhibition has been 80%''

If someone takes say an GABA-A agonist like Xanax, how much CRH inhibition will there be? 53,3%, 65%,7 or 80%?
Like how much inhibition can GABA on its own have? Is there a limit or can GABA inhibit 100% of the CRH?
Lets say GABA inhibits 80% and I take a supplement called St John's wort which has been shown to reduce CRH by 20% ( https://www.ncbi.nlm...pubmed/11526469 ), would that mean taken together it would be 100% inhibition?
At the moment im looking at a hormone called 5a-dhp that is a precursor to allopregnanolone which is an GABA-A modulator, im curious how much it will help with blocking CRH, (cortisol releasing hormone) if it is only 80% since that is only as much as your BBB (blood brain barrier) allows? And if so would combining it with St John's wort increase it from 80% to 100% so you are at a constant normal CRH base.
Also make it clear it is the hypericin content not Hyperforin that decreases CRH:https://www.ncbi.nlm...pubmed/12865894

I hope this made sense... im not looking for medical advice im just curious how much CRH GABA can be allowed to block.

not fully block but just normal base. crh is not always active it is only active during stress right.
 
So say someone has an crh-secreting tumour, then he would need 100% block in order for his body to return to normal base right
im just curious how much GABA , gaba-a specfically blocks CRH, and what would happen if you combine it with st johns wort which has been shown to reduce crh by 20%. so what numbers are we talking?

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#2 farshad

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Posted 07 July 2018 - 05:33 PM

nobody knows what im talking about?


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