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Conflicting EGCg dosing

egcg

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#1 John250

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Posted 07 September 2018 - 08:24 PM


Ncbi states it’s best absorbed on an empty stomach

https://www.ncbi.nlm...ubmed/26783711/

I realize many supplement companies still put on the bottle take with food even when it’s best absorbed on an empty stomach but I noticed that the NOW EGCg that I have not only says take with food but also says do not take this supplement on an empty stomach. That’s the first time I’ve even seen a supplement say that.

https://s3.images-ih...ow04757/l/5.jpg

#2 Dorian Grey

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Posted 08 September 2018 - 12:11 AM

When it comes to EGCg I'd say "less is more".

 

Green tea extracts have a notorious reputation for toasting livers in those who are megadosing GTE trying to lose weight.  

 

https://livertox.nih.gov/GreenTea.htm

 

Likelihood score: A (well established cause of clinically apparent liver injury).  YIKES!   

 

I took a low dose green tea extract compounded with caffeine to help get me through my post lunch crump at work, & noticed this would kill my apatite for up to 6 hours.  It wasn't the caffeine, as I can drink coffee and still be ready for dinner an hour or two later.  

 

I realize EGCg is only one component of GTE, but apparently its the primary active component.  


Edited by Dorian Grey, 08 September 2018 - 12:12 AM.

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#3 John250

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Posted 08 September 2018 - 12:42 AM

When it comes to EGCg I'd say "less is more".

Green tea extracts have a notorious reputation for toasting livers in those who are megadosing GTE trying to lose weight.

https://livertox.nih.gov/GreenTea.htm

Likelihood score: A (well established cause of clinically apparent liver injury). YIKES!

I took a low dose green tea extract compounded with caffeine to help get me through my post lunch crump at work, & noticed this would kill my apatite for up to 6 hours. It wasn't the caffeine, as I can drink coffee and still be ready for dinner an hour or two later.

I realize EGCg is only one component of GTE, but apparently its the primary active component.


Seems like pretty high doses in the study. I usually take two pills on an empty stomach. Never noticed any increase in liver enzymes.

#4 joelcairo

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Posted 08 September 2018 - 08:12 PM

I think the main culprit is protein. Sugar, vitamin C and omega-3 fatty acids can actually improve absorption.

http://www.ncbi.nlm....les/PMC3189735/

 

One reason for taking supps with food is that on an empty stomach they can produce irritation. There are some that I can only take with food or suffer the consequences.

 

The risk of liver damage is real but IMO exaggerated. It has only been documented in a handful of cases for pretty high doses. Do not megadose EGCG.

 



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#5 John250

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Posted 08 September 2018 - 11:35 PM

I’m surprised how many supplements need to be taken on an empty stomach for proper absorption. EGCg, quercetin, lumbrokinnase, nattokinnase, Citrus Bergamot, Siberian and panax ginseng, MitoQ, astragalus, Arjuna, NAC, etc..





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