Our study shows that daily gene expression is highly responsive to fasting through temporal coordination of the circadian clock and fasting-sensitive TFs. This reorganization of gene regulation by fasting could prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene expression. Therefore, optimal fasting in a timed manner would be strategic to confer robust circadian oscillation that ultimately benefits health and protects against aging-associated diseases.
https://www.cell.com...1247(18)31868-0
