This detailed study seems to have gone under the radar:
Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes
https://synapse.kore...nrp.2019.13.1.3
This study suggests the potential role of NR in inflammation regulation and mitochondrial biogenesis in a model of hepatocyte steatosis. As inflammation and mitochondrial dysfunction are involved in the pathophysiology in NAFLD, our study has potential clinical and public health implications if the findings are confirmed in human clinical trials. In conclusion, our findings demonstrate that NR treatment attenuates hepatic inflammation, and induces mitochondrial biogenesis in mouse hepatocytes. These findings suggest the therapeutic value of NR in hepatic inflammation and impaired mitochondrial biogenesis.