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MK4 on its own?

mk4

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#1 experimenting

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Posted 24 February 2019 - 03:17 PM


Do you need k1 and mk7....the latter makes me feel weird. But I did read that taking only high dose mk4 leads to some issues. Anyone know anything?

#2 maxwatt

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Posted 24 February 2019 - 03:53 PM

In Korea MK4 is used in very high doses to treat osteoporosis.  I don't know of any side effects.

High doses of MK7 might be undesireable.  I wouldn't use more than 90 to 100 mg per day.  In what way does it make you feel wierd?

IF you are eating greens you should be getting all the K1 you need. 



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#3 experimenting

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Posted 24 February 2019 - 04:50 PM

In Korea MK4 is used in very high doses to treat osteoporosis. I don't know of any side effects.
High doses of MK7 might be undesireable. I wouldn't use more than 90 to 100 mg per day. In what way does it make you feel wierd?
IF you are eating greens you should be getting all the K1 you need.


Dunno MK7 at 200mcg/day gives me weird cognition (spacey/add) ruins sleep and leads to joint clicking (excess bone effects)?

K2 Mk4 has none of these problems. Once again you run into megadose issues though. MK4 at 15mg is a monster dose-and there are studies that show that this actually leads to more calcium uptake, which doesn’t seem desirable:

Vitamin K supplementation promoted the reduction in urinary calcium excretion and stimulated intestinal calcium absorption in rats on a normal calcium diet. Vitamin D supplementation stimulated intestinal calcium absorption with prevention of the abnormal elevation of serum PTH concentrations, prevented hypocalcemia in rats fed with a low calcium diet, and stimulated intestinal calcium absorption in rats fed with a normal calcium diet. The stimulation of intestinal calcium absorption was associated with increased 1,25(OH)D concentrations. An additive effect of vitamin K and vitamin D on intestinal calcium absorption was only found in rats fed with a normal calcium diet. This study shows the differential effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed with a normal or low calcium diet.

https://www.ncbi.nlm...les/PMC5613455/

You’ll see I’ve posted about fighting hypercalcemia a lot on these forums. One theory I now have is that I probably was massively overdoing VitK which may have made the problem worse. Aiming now for 100mcg k1 and 200mcg k2-still something like 4x the RDA alongside 5k iu D3.

Thoughts on that?
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#4 tunt01

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Posted 24 February 2019 - 07:51 PM

Typical dose in Japan is 45 mg of MK4 for osteo.



#5 experimenting

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Posted 24 February 2019 - 08:41 PM

Typical dose in Japan is 45 mg of MK4 for osteo.


Yeah i have no idea how that didn’t have side effects. Isn’t that hundreds of times what any diet would have
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#6 CedarWind

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Posted 26 February 2019 - 02:02 AM

MK4 is generally the safest and most effective. If you take just one form I would go with MK4, but they do work slightly differently. "FutureBiotics, Vitamin K Triple Play" is a good blend of K1, MK4 and a little MK7


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#7 maxwatt

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Posted 26 February 2019 - 03:32 AM

MK4 tends to deposit calcium in bones.

MK7 tends to remove it from your arteries (or at least prevent it from depositing.)

I don't know how these would affect osteoarthritis


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