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Antioxident apocynin for skin rejuvenation

rejuvenation col17a1 y27632 apocynin

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#61 Rorororo

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Posted 01 November 2020 - 03:01 AM

Any updates on this? I wish there were sources other than eBay. If I were to use this it would be through oral ROA. The trust factor for me is the biggest issue. I don't want to put something in my body that I purchased off of eBay. I'm not saying it's fake I'm saying I'm not willing to take the risk. Maybe this is a stupid question but why haven't companies like Nootropics Depot come up with their own Apocynin product? Not enough research on it? It seems like a potential game changer in terms of skin rejuvenation and other areas of the body including the brain! Arteries too!

#62 Fafner55

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Posted 02 November 2020 - 05:12 PM

I took a 8000 mg dose of apocynin 2x/day for 5 days. This dose targeted a 100 uM in vivo concentration, assumed 40 L total body fluids and 8.3% bioavailability. No positive outcome was observed.


(100 μM)(166.17 g/mol) = 0.01662 g/L = 16.62 mg/L
(16.62 mg/L)(40 L/body) = 664.5 mg/body
Assuming 8.3% bioavailability, 
( 664.5 mg)/0.083 = 8006 mg
Before taking this dose I was aware that apocynin could increase susceptibility to infection by its suppression of extracellular NADPH.
“Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass” (2015) https://www.nature.c...icles/srep18572
In fact, shortly after this 5 day self experiment I experienced a large, painful stye under my right lower eyelid. It took months for this infection to disappear. This was my first stye ever and an unlikely coincidence.
I don't recommend taking apocynin orally.

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