5 replies to this topic

[Ivohubchev]

So my dopamine receptors have been downregulated from years of porn abuse. Now I suffer from low energy, no motivation whatsoever and anxiety. Has anyone succesfuly upregulated their receptors? I read uridine is supposed to help but there are a lot of reports claiming it's not safe. Innositol is supposed to help but it didn't have much of an effect on me.
Thanks

[DaveX]

There is nothing unsafe abput Uridine, in my opinion. In terms of unsafe reports, I think you would find way more for many other things. It's normally safe, with tendency to being very healthy.

An other example of "potentially unsafe": EGCG (green tea extract). It's super-healthy, but can potentially impact liver health negatively. Uridine is similar, with the difference that it's actually healthy for the liver in 90% of cases... (So what applies to EGCG all the time, without making it really unsafe at all, applies almost not at all to Uridine or is actually reversed.)
There is another one with a similar profile: Acetylcysteine is SUPER-healthy for the liver -except when you are recovering right now from alcohol-intake: therefore you have to take it before or when sober (not while drunk or detoxifying).

That's basically what you're dealing with, but I have no idea what else you might be referring to, and in the case of Uridine, this is nothing.

My two cents, as far as I'm concerned this should just be a side-note.


And to talk about something else: maybe consider Magnesium Threonate for NMDA-antagonism/upregulation and overall brain health. (There is a huge old thread speculating about Magnesium Threonate being different from any other Magnesium, and I can confirm it definitely is. Its psychological effect is about 500% stronger than Mg-Citrate.)
Also Zinc with Histidine (common combo) as a a NMDA antagonist and overall physical health.

Edited by DaveX, 12 August 2019 - 07:41 PM.

[Ivohubchev]

Thanks for the reply, yes I may consider uridine. Do you have any experience with it, is the upregulation permanent, even after stopping suplementation? Also wouldn't upregulation of the NMDA actually be a bad thing because it incraeses anxiety?

Edited by Ivohubchev, 12 August 2019 - 08:36 PM.

[Rocket]

The entire premise of dopamine receptors being downregulated by looking at images over time is silly.

 

These substances may help with dopamine....

 

St John's Wort (OTC)

Pramipexole (Research Chem)

9MBC (OTC)

Lisuride (Reseach Chem)

Tyrosine ( OTC)

Requip (Rx)

[MichaelFocus22]

1. Their is no dopamine down-regulation it's simply watching years and years of pornography, I've made a whole thread dedicated  to this entire topic but sense I've received so little support I will be making my own website with my own content transitioning away from this platform entirely. Perhaps, Once I achieve my 365 day goal, I will stop posting on this platform all together and focus on new nootropic interventions. Here's the thread, https://www.longecit...-transmutation/ Everything your talking about I've already done, even at 178 days before I caved I had made great strides but still had these latent addictive tendencies with women that I had hard times stopping. If you stop pornography your going to have increased aggression, higher charisma at day 150, URETHRA incontinence was the worst of all, I ruined half of my boxers sense I kept leaking which may be damage to my urethra I suppose? To be clear most people who ABUSED hard-core pornography often were self-medicating for a deeper neurogenetic problem. Obviously, I have ADHD-PI and it was my hope that it would cure me? Which it didn't but then again I didn't get to my goal, so I'm restarting again, just fyi most people have no idea how painful it is to do this. I mean it's like really painful... Stacks aren't going to work but obviously they don't like that response ,hence why I'm getting my own website. Anyways, the best method I found was lots of exercise assuming you keep CONSISTENCY but typically you may have a deeper underlying problem. Goodluck.

[Ivohubchev]

Hey, thanks for the reply. In your case there may not be a downregulation but I deffinetly have one. I know it because when I take a substance that incraeses dopamine like Mucuna Purriens my anxiety, depression, low energy etc. is gone. But obviously this is not sustainable for the long run hence I am trying to upregulate the receptors.
Here is a quote from a Harvard scientist named Kevin Majeres which is relevant and describes my exact expirience as well:

“This first exposure to a new female who is a potential mate wasn’t something that happened a lot to our ancestors; maybe only once in their lives; so the brain thinks this is a big deal. It doesn’t know that now the game has completely changed: it doesn’t understand that these are virtual females only; so with each new one it causes another flood of dopamine, time after time, click after click, as long as he continues. It’s a dopamine binge.

This is why pornography causes a vicious circle. When someone views pornography, he gets overstimulated by dopamine; so his brain destroys some dopamine receptors. This makes him feel depleted, so he goes back to pornography, but, having fewer dopamine receptors, this time it requires more to get the same dopamine thrill; but this causes his brain to destroy more receptors; so he feels an even greater need for pornography to stimulate him.

So as guys keep gaming the dopamine system, they start to find that they have to use pornography for longer and longer periods to have the same effect, and they have to visit more and more sites."

Edited by Ivohubchev, 15 August 2019 - 08:30 PM.