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Dead probiotic strain shown to reduce harmful, aging-related inflammation

aging cell wall cognition goblet cell inflammation leaky gut lipoteic acid metabolism mucin probiotics

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#1 Engadin

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Posted 10 December 2019 - 02:16 PM


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S O U R C E :    MedicalXpress

 

B E H I N D   P A Y W A L L   P R I M A L   S O U R C E :   GeroScience [Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice]

 

 

 

 

 

 

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Scientists at Wake Forest School of Medicine have identified a dead probiotic that reduces age-related leaky gut in older mice. The study is published in the journal GeroScience.
 
But what exactly is leaky gut and what does a probiotic—dead or alive—have to do with it?
 
Some research has indicated that leaky gut, in which microbes and bacteria in the gut leak into the blood stream through holes or cracks in the intestinal lining, causes an increase in low-grade inflammation, and these conditions are common in older people. This resulting inflammation is thought to play a role in the development of many age-related diseases, such as diabetes, obesity, cancer, cardiovascular disease and decline in physical and cognitive functions.
 
"We know that probiotics are instrumental in maintaining a healthy gut and preventing leakage, but there isn't much data available to pinpoint which ones work and which ones don't," said Hariom Yadav, Ph.D., assistant professor of molecular biology at Wake Forest School of Medicine and principal investigator of the study.
 
"Determining the strain that is most effective at reducing leaky gut and inflammation would help us target more effective strategies to address the problem, and help explain why probiotics work for some people but not others."
 
In the study, Yadav's team first screened eight strains of human-origin probiotics in roundworms, a commonly used model with a short lifespan of 11 to 20 days. They discovered that a strain of Lactobacillus paracasei (D3-5), even in the non-viable or heat-killed form, extended the roundworms' life span.
 
They then tested their initial findings in mice. The results showed that feeding heat-killed D3-5 to older mice prevented high fat diet-induced metabolic dysfunctions, decreased leaky gut and inflammation, and improved physical and cognitive functions.
 
 
 
 
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#2 Seganfredo

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Posted 30 December 2019 - 12:45 AM

Interesting. Especially while fighting IBS with a billion sub autoimmune dis-eases and symptoms stemming from it.

Now the question would be, just this specific L. paracasei strain D3-5 has this effect? And if so, how to get one's hands on it?

Any info on how to beat IBS, leaky gut/ brain, autoimmunity, and HPA axis dysfunction is well appreciated.
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#3 rodentman

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Posted 30 December 2019 - 05:40 PM

Interesting. Especially while fighting IBS with a billion sub autoimmune dis-eases and symptoms stemming from it.

Now the question would be, just this specific L. paracasei strain D3-5 has this effect? And if so, how to get one's hands on it?

Any info on how to beat IBS, leaky gut/ brain, autoimmunity, and HPA axis dysfunction is well appreciated.

 

Yogurt seems to help me a bit.  But I have Crohn's disease.   But yes, I am also interesting in this strain, and would love to test it as soon as it becomes available.



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Also tagged with one or more of these keywords: aging, cell wall, cognition, goblet cell, inflammation, leaky gut, lipoteic acid, metabolism, mucin, probiotics

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