receptors function database
ibtisam_midlet 15 Dec 2019
what is receptors function database:
preview:
how to use:
for IOS users use google sheets for ios
for desktop use this link for google docs (it will open the app in android)
that link will changed when new version maked
yowza 15 Dec 2019
I think this idea is very useful. What software did you use to format those images may I ask? It's very succinct and cleverly done.
As maybe a sequel to this, I think compensatory mechanisms could be added. We all know certain types of agonists tend to de-sensitize receptors while certain types of antagonists tend to maybe encourage a compensatory mechanism to come into play...
I don't want to make any statements on this quite yet but if you have more info. in this regard it would be interesting to see as well.
Edited by yowza, 15 December 2019 - 06:15 AM.
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ibtisam_midlet 15 Dec 2019
I think this idea is very useful. What software did you use to format those images may I ask? It's very succinct and cleverly done.
As maybe a sequel to this, I think compensatory mechanisms could be added. We all know certain types of agonists tend to de-sensitize receptors while certain types of antagonists tend to maybe encourage a compensatory mechanism to come into play...
I don't want to make any statements on this quite yet but if you have more info. in this regard it would be interesting to see as well.
Do you mean HT2A receptors antagonist? I know they lead to desenistation.
>>https://en.m.wikiped...5-HT2A_receptor
but for complicated cus, it's limited and there an unlimited upregulation to opposite some of that effect.
Your idea need an other database for drugs/receptor interaction with I already have , but it's experimental with a lot of bugs, so it's for personal use for now, might I will develop it for public some day.
yowza 15 Dec 2019
Do you mean HT2A receptors antagonist? I know they lead to desenistation.
>>https://en.m.wikiped...5-HT2A_receptor
but for complicated cus, it's limited and there an unlimited upregulation to opposite some of that effect.
Your idea need an other database for drugs/receptor interaction with I already have , but it's experimental with a lot of bugs, so it's for personal use for now, might I will develop it for public some day.
I'd be interested in seeing that.
I read about the drug Memantine lately pertaining to NMDA receptors. It's supposedly an "uncompetitive antagonist" unlike "noncompetitive antagonists".
I will dig some past research up on the subject before commenting further but I think I recall hearing that pertaining to the NMDA system the medication stabilizes the Glutamergic system to an extent (important to avoid uneven brainwaves or excitotoxicity as I recall) while also enhancing cognition in some individuals pertaining to evening out the Glutamergic system with some potential offlabel usages. Downside of course is NMDA isn't the only receptor it hits of course so not advocating for it yet (other receptors besides NMDA may trigger in maybe not the same way).
In any case, I like the table graph that you have going. There's so many aspects to "Pharmacomodulation" I've attached a few tables from Wikipedia (yeah, I know it's not the best source but I like the tables at the bottom of the pages) for reference sake. Your table though gets into a lot more specifics though pertaining to the "receptor" category that perhaps could provide added insight to this file (the part ranging from agonist, partial agonist, antagonist, PAM, and NAM) and the types of "agonists" and "antagonists" as seen in 2nd attached file. Whether the body desensitizes the receptor or upregulates in response to how a receptor is interacted with I think is a key downstream question.
Too many medications have complex profiles not targeting just 1 receptor (let alone Ki Constants) so still pretty difficult to distinguish what works and what doesn't even with everything put out in table format but it's certainly helpful as a reference point.
Thanks for the information you posted.
Attached Files
Edited by yowza, 15 December 2019 - 09:07 AM.
ibtisam_midlet 15 Dec 2019
I'd be interested in seeing that.
I read about the drug Memantine lately pertaining to NMDA receptors. It's supposedly an "uncompetitive antagonist" unlike "noncompetitive antagonists".
I will dig some past research up on the subject before commenting further but I think I recall hearing that pertaining to the NMDA system the medication stabilizes the Glutamergic system to an extent (important to avoid uneven brainwaves or excitotoxicity as I recall) while also enhancing cognition in some individuals pertaining to evening out the Glutamergic system with some potential offlabel usages. Downside of course is NMDA isn't the only receptor it hits of course so not advocating for it yet (other receptors besides NMDA may trigger in maybe not the same way).
In any case, I like the table graph that you have going. There's so many aspects to "Pharmacomodulation" I've attached a few tables from Wikipedia (yeah, I know it's not the best source but I like the tables at the bottom of the pages) for reference sake. Your table though gets into a lot more specifics though pertaining to the "receptor" category that perhaps could provide added insight to this file (the part ranging from agonist, partial agonist, antagonist, PAM, and NAM) and the types of "agonists" and "antagonists" as seen in 2nd attached file. Whether the body desensitizes the receptor or upregulates in response to how a receptor is interacted with I think is a key downstream question.
Too many medications have complex profiles not targeting just 1 receptor (let alone Ki Constants) so still pretty difficult to distinguish what works and what doesn't even with everything put out in table format but it's certainly helpful as a reference point.
Thanks for the information you posted.
yowza 15 Dec 2019
Edited by yowza, 15 December 2019 - 11:40 PM.
yowza 17 Dec 2019
I might of gotten ahead of myself a bit in terms of 1st I will need to more so understand the goal in mind for any additional database being made (not suggesting changing anything on your current one).
Also, in terms of help it would mainly just be me giving some feedback or look into something stop and go as I'm pretty limited lately and pretty much just stopped by the forums again just to look over what everyone here is talking about now days and my focus may be limited more so than perhaps it once was. Still, feel free to question anything I say as I put it out more so based on what I remember reading and personal experience (my goals and how I may respond to some substances may be totally different of course).
Edited by yowza, 17 December 2019 - 06:25 AM.
ibtisam_midlet 18 Jun 2020
in (receptor) column mean = transporter.
in (receptor) column mean = better to agonist.
for IOS users use google sheets for ios
for desktop use this link for google docs (it will open the app in android)
that link will changed when new version made
DividedMind2008 22 Jun 2020
This is great. Thank you so much for this.
What would be better is knowing what drugs typically attach to which receptor and what affect they have.
So if "zyprexa' is a D2A (for example) antagonist - we could look up on the chart to see what the desired effect is supposed to be....
Thanks again.
Chris
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Aj28 19 Feb 2021
Why at the beta adrenergic receptors it states "anxiolytic" when agonised?
For example propranolol is an b1,b2,b3 antagonist and is highly anxiolytic?