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Genetics of extreme human longevity to guide drug discovery for healthy ageing

drug discovery genetics genome-wide association studies

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#1 Engadin

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Posted 31 July 2020 - 09:06 PM


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P A Y W A L L E D   S O U R C E :   nature metabolism

 

 

 

 

 

 

Abstract

 

Ageing is the greatest risk factor for most common chronic human diseases, and it therefore is a logical target for developing interventions to prevent, mitigate or reverse multiple age-related morbidities. Over the past two decades, genetic and pharmacologic interventions targeting conserved pathways of growth and metabolism have consistently led to substantial extension of the lifespan and healthspan in model organisms as diverse as nematodes, flies and mice.
 
Recent genetic analysis of long-lived individuals is revealing common and rare variants enriched in these same conserved pathways that significantly correlate with longevity. In this Perspective, we summarize recent insights into the genetics of extreme human longevity and propose the use of this rare phenotype to identify genetic variants as molecular targets for gaining insight into the physiology of healthy ageing and the development of new therapies to extend the human healthspan.
 
 
 
 
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Also tagged with one or more of these keywords: drug discovery, genetics, genome-wide association studies

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